ARCN1
Arhain 1 is a protein koji je kod ljudi kodiran genom ARCN1. [5]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 511 aminokiselina, a molekulska težina 57.210 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MVLLAAAVCT | KAGKAIVSRQ | FVEMTRTRIE | GLLAAFPKLM | NTGKQHTFVE | ||||
| TESVRYVYQP | MEKLYMVLIT | TKNSNILEDL | ETLRLFSRVI | PEYCRALEEN | ||||
| EISEHCFDLI | FAFDEIVALG | YRENVNLAQI | RTFTEMDSHE | EKVFRAVRET | ||||
| QEREAKAEMR | RKAKELQQAR | RDAERQGKKA | PGFGGFGSSA | VSGGSTAAMI | ||||
| TETIIETDKP | KVAPAPARPS | GPSKALKLGA | KGKEVDNFVD | KLKSEGETIM | ||||
| SSSMGKRTSE | ATKMHAPPIN | MESVHMKIEE | KITLTCGRDG | GLQNMELHGM | ||||
| IMLRISDDKY | GRIRLHVENE | DKKGVQLQTH | PNVDKKLFTA | ESLIGLKNPE | ||||
| KSFPVNSDVG | VLKWRLQTTE | ESFIPLTINC | WPSESGNGCD | VNIEYELQED | ||||
| NLELNDVVIT | IPLPSGVGAP | VIGEIDGEYR | HDSRRNTLEW | CLPVIDAKNK | ||||
| SGSLEFSIAG | QPNDFFPVQV | SFVSKKNYCN | IQVTKVTQVD | GNSPVRFSTE | ||||
| TTFLVDKYEI | L |
Funkcija
Ovaj gen nalazi se u regiji koja uključuje gen za leukemiju mjješovite loze i gene integracije virusa 1 šperona virusa leukemije, gdje se javlja višestostruka bolest usljed hromosomskih translokacija. To je unutarćelijski protein. Arhainske sekvence su među eukariotima dobro konzervirane i ovaj protein može imati temeljnu ulogu u biologiji eukariotskih ćelija. Ima sličnosti sa proteinima toplotnog šoka i proteinima povezanim s klatrinom, a može biti uključen u strukturu vezikula ili vezikulski promet
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000095139 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032096 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Archain 1". Pristupljeno 22. 6. 2016.
- ^ "UniProt, P48444". Pristupljeno 16. 8. 2021.
Dopunska literatura
- Deng K, Gao F, Zheng P, Gong W, Sun Z (2012). "Crystallization and preliminary X-ray analysis of the C-terminal domain of δ-COP, a medium-sized subunit of the COPI complex involved in membrane trafficking". Acta Crystallographica Section F. 68 (Pt 7): 829–31. doi:10.1107/S1744309112022798. PMC 3388933. PMID 22750876.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.