APOF

APOF

Identifikatori

Vanjski ID-jevi

OMIM: 107760 MGI: 104539 HomoloGene: 48030 GeneCards: APOF

Lokacija gena (čovjek)

Hrom.	Hromosom 12 (čovjek)^[1]

Bend	12q13.3	Početak	56,360,568 bp^[1]
Bend	12q13.3	Kraj	56,362,857 bp^[1]

Lokacija gena (miš)

Hrom.	Hromosom 10 (miš)^[2]

Bend	10 D3\|10 76.5 cM	Početak	128,103,866 bp^[2]
Bend	10 D3\|10 76.5 cM	Kraj	128,106,022 bp^[2]

Obrazac RNK ekspresije

Više referentnih podataka o ekspresiji

Ontologija gena
Molekularna funkcija	• cholesterol binding • signaling receptor binding • lipid transporter activity
Ćelijska komponenta	• low-density lipoprotein particle • high-density lipoprotein particle • extracellular region • Vanćelijsko
Biološki proces	• steroid metabolic process • lipid transport • cholesterol metabolic process • lipid metabolism
Izvori:Amigo / QuickGO

Vrste

Čovjek

Miš


319


103161


ENSG00000175336


ENSMUSG00000047631


Q13790


Q91V80

RefSeq (mRNK)


NM_001638


NM_133997

RefSeq (bjelančevina)


NP_001629


NP_598758

Lokacija (UCSC)

Chr 12: 56.36 – 56.36 Mb

Chr 10: 128.1 – 128.11 Mb

PubMed pretraga

^[3]

^[4]

Pogledaj/uredi – čovjek

Pogledaj/uredi – miš

Apolipoprotein F

Identifikatori
Simbol	APOF

Apolipoprotein F je protein koji je kod ljudi kodiran genom APOF.^[5]^[6]

Proizvod ovog gena jedan je od manjih apolipoproteina pronađenih u plazmi. Ovaj protein formira multiproteinska komplekse sa lipoproteinima i može biti uključen u transport i/ili esterifikaciju holesterola.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 326 aminokiselina, a molekulska težina 35.399 Da.^[7]

10		20		30		40		50
MTGLCGYSAP		DMRGLRLIMI		PVELLLCYLL		LHPVDATSYG		KQTNVLMHFP
LSLESQTPSS		DPLSCQFLHP		KSLPGFSHMA		PLPKFLVSLA		LRNALEEAGC
QADVWALQLQ		LYRQGGVNAT		QVLIQHLRGL		QKGRSTERNV		SVEALASALQ
LLAREQQSTG		RVGRSLPTED		CENEKEQAVH		NVVQLLPGVG		TFYNLGTALY
YATQNCLGKA		RERGRDGAID		LGYDLLMTMA		GMSGGPMGLA		ISAALKPALR
SGVQQLIQYY		QDQKDANISQ		PETTKEGLRA		ISDVSDLEET		TTLASFISEV
VSSAPYWGWA		IIKSYDLDPG		AGSLEI

D: Asparaginska kiselina

E: Glutaminska kiselina

Y: Tirozin

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175336 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047631 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Day JR, Albers JJ, Gilbert TL, Whitmore TE, McConathy WJ, Wolfbauer G (Oct 1994). "Purification and molecular cloning of human apolipoprotein F". Biochem Biophys Res Commun. 203 (2): 1146–51. doi:10.1006/bbrc.1994.2302. PMID 8093033.
^ ^a ^b "Entrez Gene: APOF apolipoprotein F".
^ "UniProt, Q13790". Pristupljeno 6. 8. 2021.

Dopunska literatura

Morton RE, Gnizak HM, Greene DJ, et al. (2008). "Lipid transfer inhibitor protein (apolipoprotein F) concentration in normolipidemic and hyperlipidemic subjects". J. Lipid Res. 49 (1): 127–35. doi:10.1194/jlr.M700258-JLR200. PMID 17901467.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kabbara A, Payet N, Cottel D, et al. (2004). "Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population". Neurosci. Lett. 363 (2): 139–43. doi:10.1016/j.neulet.2004.03.066. PMID 15172102. S2CID 27752858.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Paromov VM, Morton RE (2003). "Lipid transfer inhibitor protein defines the participation of high density lipoprotein subfractions in lipid transfer reactions mediated by cholesterol ester transfer protein (CETP)". J. Biol. Chem. 278 (42): 40859–66. doi:10.1074/jbc.M306580200. PMID 12907677.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wang X, Driscoll DM, Morton RE (1999). "Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F". J. Biol. Chem. 274 (3): 1814–20. doi:10.1074/jbc.274.3.1814. PMID 9880564.
Koren E, McConathy WJ, Alaupovic P (1983). "Isolation and characterization of simple and complex lipoproteins containing apolipoprotein F from human plasma". Biochemistry. 21 (21): 5347–51. doi:10.1021/bi00264a035. PMID 6816269.
Olofsson SO, McConathy WJ, Alaupovic P (1978). "Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma". Biochemistry. 17 (6): 1032–6. doi:10.1021/bi00599a014. PMID 204339.

Vanjski linkovi

Lokacija ljudskog genoma APOF i stranica sa detaljima o genu APOF u UCSC Genome Browseru.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.