AMOTL2
Angiomotinoliki protein 2 jest protein koji je kod ljudi kodiran genom AMOTL2 sa hromosoma 3.[5]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 779 aminokiselina, а molekulska težina 85.764 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MRTLEDSSGT | VLHRLIQEQL | RYGNLTETRT | LLAIQQQALR | GGAGTGGTGS | ||||
| PQASLEILAP | EDSQVLQQAT | RQEPQGQEHQ | GGENHLAENT | LYRLCPQPSK | ||||
| GEELPTYEEA | KAHSQYYAAQ | QAGTRPHAGD | RDPRGAPGGS | RRQDEALREL | ||||
| RHGHVRSLSE | RLLQLSLERN | GARAPSHMSS | SHSFPQLARN | QQGPPLRGPP | ||||
| AEGPESRGPP | PQYPHVVLAH | ETTTAVTDPR | YRARGSPHFQ | HAEVRILQAQ | ||||
| VPPVFLQQQQ | QYQYLQQSQE | HPPPPHPAAL | GHGPLSSLSP | PAVEGPVSAQ | ||||
| ASSATSGSAH | LAQMEAVLRE | NARLQRDNER | LQRELESSAE | KAGRIEKLES | ||||
| EIQRLSEAHE | SLTRASSKRE | ALEKTMRNKM | DSEMRRLQDF | NRDLRERLES | ||||
| ANRRLASKTQ | EAQAGSQDMV | AKLLAQSYEQ | QQEQEKLERE | MALLRGAIED | ||||
| QRRRAELLEQ | ALGNAQGRAA | RAEEELRKKQ | AYVEKVERLQ | QALGQLQAAC | ||||
| EKREQLELRL | RTRLEQELKA | LRAQQRQAGA | PGGSSGSGGS | PELSALRLSE | ||||
| QLREKEEQIL | ALEADMTKWE | QKYLEERAMR | QFAMDAAATA | AAQRDTTLIR | ||||
| HSPQPSPSSS | FNEGLLTGGH | RHQEMESRLK | VLHAQILEKD | AVIKVLQQRS | ||||
| RRDPGKAIQG | SLRPAKSVPS | VFAAAAAGTQ | GWQGLSSSER | QTADAPARLT | ||||
| TDRAPTEEPV | VTAPPAAHAK | HGSRDGSTQT | EGPPDSTSTC | LPPEPDSLLG | ||||
| CSSSQRAASL | DSVATSRVQD | LSDMVEILI |
Funkcija
Angiomotin je protein koji veže angiostatin, cirkulirajući inhibitor stvaranja novih krvnih sudova (angiogeneza). Angiomotin posreduje angiostatinom u inhibiciji migracije endotelnih ćelija i formiranja mikrotubula in vitro. Protein koji je kodiran ovim genom povezan je s angiomotinom i član je porodice proteinskih motina.[5]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000114019 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032531 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: AMOTL2 angiomotin like 2".
- ^ "UniProt, Q9Y2J4" (jezik: engleski). Pristupljeno 6. 11. 2021.
Dopunska literatura
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
- Bratt A, Wilson WJ, Troyanovsky B, et al. (2003). "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains". Gene. 298 (1): 69–77. doi:10.1016/S0378-1119(02)00928-9. PMID 12406577.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Vanjski linkovi
- Lokacija ljudskog genoma AMOTL2 i stranica sa detaljima o genu AMOTL2 u UCSC Genome Browseru.
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