zh 卡氏間質細胞

卡氏間質細胞
Interstitial cell of Cajal
卡氏間質細胞; Interstitial cell of Cajal
标识字符
拉丁文	cellulae interstitiales stimulantes
MeSH	D056885
FMA	FMA:86573
	《解剖學術語》 [在维基数据上编辑]

卡氏間質細胞（interstitial cell of Cajal、ICC，卡哈爾細胞）是在胃腸道中發現的一種間質細胞。有不同類型且具有不同的功能。其中「肌間質細胞」（Myenteric Interstitial cells of Cajal [ICC-MY] ）作為起搏器產生慢波電位(slow wave potential)，能導致平滑肌的收縮。^[2]^[3]

另一種，"肌內卡氏間質細胞"(Intramuscular Interstitial cells of Cajal ICC-IM)參與平滑肌細胞的激活，通過它們進行神經遞質作用。^[4]某些鈣激活氯通道(calcium-activated chloride channels (CaCCs))現在已知在調節人體胃腸的ICC中發揮重要的作用，特別是在鈣激活氯通道ANO1。^[5]最近的一篇評論指出，卡巴膽鹼(carbachol)通過這一通道來增加ICC的活動。^[5]^[6]"敲除ANO1基因"(ANO1-knockout)的老鼠不能在人體產生慢波及ANO1通道抑製劑來阻斷慢波的產生。^[5]

許多類型的平滑肌組織現已證明含有ICC，但除了少數例外的細胞且這些例外的細胞功能還是是未知的；故而目前這是一個很活躍的研究領域。

而卡氏間質細胞衍自中胚层。^[7]

慢波活動的作用

ICC作為電子心臟起搏器，及在胃腸道(gastrointestinal tract)產生自發性的慢波電位(slow wave potential)。

ICC起搏細胞的頻率

ICC起搏器活動的頻率不同在胃腸道的不同區域之情況：^[8]

病理

ICC 被認為是從胃腸道基質腫瘤(GISTs)所產生的細胞。^[9]

命名

卡氏間質細胞是以圣地亚哥·拉蒙-卡哈尔來命名的，^[10]"聖地亞哥·拉蒙 - 卡哈爾"他是一位西班牙籍的病理學家以及诺贝尔生理学或医学奖的得主。

註釋

^ 存档副本. [2016-09-18]. （原始内容存档于2016-03-03）.
^ Hennig GW, Spencer NJ, Jokela-Willis S, Bayguinov PO, Lee HT, Ritchie LA, Ward SM, Smith TK, Sanders KM. ICC-MY coordinate smooth muscle electrical and mechanical activity in the murine small intestine. Neurogastroenterol. Motil. May 2010, 22 (5): e138–51. PMC 2856807 . PMID 20059699. doi:10.1111/j.1365-2982.2009.01448.x.
^ Sanders K, Koh S, Ward S. Interstitial cells of cajal as pacemakers in the gastrointestinal tract. Annu Rev Physiol. 2006, 68: 307–343. PMID 16460275. doi:10.1146/annurev.physiol.68.040504.094718.
^ Kito Y. The functional role of intramuscular interstitial cells of Cajal in the stomach. J Smooth Muscle Res. 2011, 47 (2): 47–53. PMID 21757854. doi:10.1540/jsmr.47.47.
^ ^5.0 ^5.1 ^5.2 Sanders KM, Zhu MH, Britton F, Koh SD, Ward SM. Anoctamins and gastrointestinal smooth muscle excitability. Exp. Physiol. February 2012, 97 (2): 200–206. PMC 3272164 . PMID 22002868. doi:10.1113/expphysiol.2011.058248.
^ Zhu MH, Sung IK, Zheng H, Sung TS, Britton FC, O'Driscoll K, Koh SD, Sanders KM. Muscarinic activation of Ca2+-activated Cl- current in interstitial cells of Cajal. J. Physiol. (Lond.). September 2011, 589 (Pt 18): 4565–82. PMC 3208225 . PMID 21768263. doi:10.1113/jphysiol.2011.211094.
^ Kursad Turksen. Embryonic Stem Cell Protocols: Differentiation models. Humana Press. 2006: 263– [14 April 2010]. ISBN 978-1-58829-784-6.
^ Pocock, Richards, Richards, Human Physiology 4/ed, Oxford University Press, 2012. ISBN 978-0-19-957493-3. p.581
^ Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med. 2006, 130 (10): 1466–78. ISSN 1543-2165. PMID 17090188. doi:10.1043/1543-2165(2006)130[1466:GSTROM]2.0.CO;2.
^ Sanders K, Ward S. Interstitial cells of Cajal: a new perspective on smooth muscle function. J Physiol. 2006, 576 (Pt 3): 721–726. PMC 1890422 . PMID 16873406. doi:10.1113/jphysiol.2006.115279.

外部連結

Overview of ICCs（页面存档备份，存于互联网档案馆） - unr.edu.

[1] 存档副本. [2016-09-18]. （原始内容存档于2016-03-03）.

[pmid20059699-2] Hennig GW, Spencer NJ, Jokela-Willis S, Bayguinov PO, Lee HT, Ritchie LA, Ward SM, Smith TK, Sanders KM. ICC-MY coordinate smooth muscle electrical and mechanical activity in the murine small intestine. Neurogastroenterol. Motil. May 2010, 22 (5): e138–51. PMC 2856807 . PMID 20059699. doi:10.1111/j.1365-2982.2009.01448.x.

[Sanders-3] Sanders K, Koh S, Ward S. Interstitial cells of cajal as pacemakers in the gastrointestinal tract. Annu Rev Physiol. 2006, 68: 307–343. PMID 16460275. doi:10.1146/annurev.physiol.68.040504.094718.

[pmid21757854-4] Kito Y. The functional role of intramuscular interstitial cells of Cajal in the stomach. J Smooth Muscle Res. 2011, 47 (2): 47–53. PMID 21757854. doi:10.1540/jsmr.47.47.

[ICC_review-5] 5.0 ^5.1 ^5.2 Sanders KM, Zhu MH, Britton F, Koh SD, Ward SM. Anoctamins and gastrointestinal smooth muscle excitability. Exp. Physiol. February 2012, 97 (2): 200–206. PMC 3272164 . PMID 22002868. doi:10.1113/expphysiol.2011.058248.

[pmid21768263-6] Zhu MH, Sung IK, Zheng H, Sung TS, Britton FC, O'Driscoll K, Koh SD, Sanders KM. Muscarinic activation of Ca2+-activated Cl- current in interstitial cells of Cajal. J. Physiol. (Lond.). September 2011, 589 (Pt 18): 4565–82. PMC 3208225 . PMID 21768263. doi:10.1113/jphysiol.2011.211094.

[Turksen2006-7] Kursad Turksen. Embryonic Stem Cell Protocols: Differentiation models. Humana Press. 2006: 263– [14 April 2010]. ISBN 978-1-58829-784-6.

[8] Pocock, Richards, Richards, Human Physiology 4/ed, Oxford University Press, 2012. ISBN 978-0-19-957493-3. p.581

[9] Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med. 2006, 130 (10): 1466–78. ISSN 1543-2165. PMID 17090188. doi:10.1043/1543-2165(2006)130[1466:GSTROM]2.0.CO;2.

[10] Sanders K, Ward S. Interstitial cells of Cajal: a new perspective on smooth muscle function. J Physiol. 2006, 576 (Pt 3): 721–726. PMC 1890422 . PMID 16873406. doi:10.1113/jphysiol.2006.115279.

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卡氏間質細胞

慢波活動的作用

ICC起搏細胞的頻率

病理

命名

註釋

外部連結

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