CEACAM8
| CEACAM8 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Идентификаторы | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Псевдонимы | carcinoembryonic antigen CGM6non-specific cross-reacting antigen NCA-95CD67 antigencarcinoembryonic antigen-related cell adhesion molecule 8carcinoembryonic antigen related cell adhesion molecule 8carcinoembryonic antigen gene family member 6CEACAM8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Внешние ID | GeneCards: [1] | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
 Информация в Викиданных | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
CEACAM8 (англ. Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); CD66b) — гликопротеин семейства раково-эмбриональных антигенов (CEA), продукт гена человека CEACAM8[1].
Функции
Белок играет роль в Ca2+-зависимой клеточной адгезии, клеточной миграции и связывании патогенов[1]. Опосредует гетерофильную клеточную адгезию с другими белками группы CEA, такими как CEACAM6.
Тканевая локализация
CEACAM8 экспрессирован исключительно на гранулоцитах и используется как маркёр этих клеток.
Примечания
Литература
- Khan W.N., Frängsmyr L., Teglund S. et al. Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. (англ.) // Genomics : journal. — Academic Press, 1992. — Vol. 14, no. 2. — P. 384—390. — doi:10.1016/S0888-7543(05)80230-7. — PMID 1427854.
- Oikawa S., Inuzuka C., Kuroki M. et al. A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains. (англ.) // J. Biol. Chem. : journal. — 1991. — Vol. 266, no. 13. — P. 7995—8001. — PMID 2022629.
- Berling B., Kolbinger F., Grunert F. et al. Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. (англ.) // Cancer Res. : journal. — American Association for Cancer Research[англ.], 1990. — Vol. 50, no. 20. — P. 6534—6539. — PMID 2208113.
- Arakawa F., Kuroki M., Misumi Y. et al. Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family. (англ.) // Biochem. Biophys. Res. Commun. : journal. — 1990. — Vol. 166, no. 3. — P. 1063—1071. — doi:10.1016/0006-291X(90)90975-S. — PMID 2306228.
- Eades-Perner A.M., Thompson J., van der Putten H., Zimmermann W. Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. (англ.) // Blood : journal. — American Society of Hematology[англ.], 1998. — Vol. 91, no. 2. — P. 663—672. — PMID 9427723.
- Torsteinsdóttir I., Arvidson N.G., Hällgren R., Håkansson L. Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids. (англ.) // Scand. J. Immunol. : journal. — 1999. — Vol. 50, no. 4. — P. 433—439. — doi:10.1046/j.1365-3083.1999.00602.x. — PMID 10520185.
- Oikawa S., Sugiyama M., Kuroki M. et al. Extracellular N-domain alone can mediate specific heterophilic adhesion between members of the carcinoembryonic antigen family, CEACAM6 and CEACAM8. (англ.) // Biochem. Biophys. Res. Commun. : journal. — 2001. — Vol. 278, no. 3. — P. 564—568. — doi:10.1006/bbrc.2000.3858. — PMID 11095950.
- Singer B.B., Scheffrahn I., Heymann R. et al. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. (англ.) // J. Immunol. : journal. — 2002. — Vol. 168, no. 10. — P. 5139—5146. — doi:10.4049/jimmunol.168.10.5139. — PMID 11994468.
- Zhao L., Xu S., Peterson C. et al. Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes. (англ.) // J. Immunol. Methods : journal. — 2002. — Vol. 270, no. 1. — P. 27—35. — doi:10.1016/s0022-1759(02)00215-6. — PMID 12379336.
- Strausberg R.L., Feingold E.A., Grouse L.H. et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2003. — Vol. 99, no. 26. — P. 16899—16903. — doi:10.1073/pnas.242603899. — PMID 12477932. — PMC 139241.
- Grimwood J., Gordon L.A., Olsen A. et al. The DNA sequence and biology of human chromosome 19. (англ.) // Nature : journal. — 2004. — Vol. 428, no. 6982. — P. 529—535. — doi:10.1038/nature02399. — PMID 15057824.
- Gerhard D.S., Wagner L., Feingold E.A. et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (англ.) // Genome Res. : journal. — 2004. — Vol. 14, no. 10B. — P. 2121—2127. — doi:10.1101/gr.2596504. — PMID 15489334. — PMC 528928.
- Ramachandran P., Boontheung P., Xie Y. et al. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (англ.) // J. Proteome Res.[англ.] : journal. — 2006. — Vol. 5, no. 6. — P. 1493—1503. — doi:10.1021/pr050492k. — PMID 16740002.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.