Reik is the first child of four of Rosemarie Reik (nee Heiles) and Helmut Gottlieb Reik (https://de.wikipedia.org/wiki/Helmut_Reik) who were both physicists. Reik was born in Aachen on 22nd August 1957, attended primary school in Braunschweig, and secondary school in Freiburg. Reik studied Physics and Medicine at the University of Freiburg and completed his medical degree at the University of Hamburg. He obtained his MD in the lab of Rudolf Jaenisch and did postdoctoral work in the lab of Azim Surani.
Career and research
Wolf Reik studies how additional information can be added to the genome through a range of processes collectively called epigenetics. He discovered some of the key epigenetic mechanisms important for mammalian development, physiology, genome reprogramming, and human diseases. His early work led to the discovery that the molecular mechanism of genomic imprinting is based on DNA methylation.[6] He uncovered non-coding RNA[7] and chromatin looping[8] regulating imprinted genes, which he showed to be involved in fetal nutrition, growth, and disease.[9] He found that the environment influences epigenetic programming in embryos, with changes in gene expression persisting in adults and their offspring.With his collaborators he discovered global epigenetic reprogramming in early embryos and in primordial germ cells10. He found that adult human cells could be substantially rejuvenated by epigenetic reprogramming induced by transient treatment with Yamanaka reprogramming factors11. [10][11]
^Reik W, Collick A, Norris ML, Barton SC, Surani MA (1987) Genomic imprinting determines methylation of parental alleles in transgenic mice. Nature328, 248-251
^Smits G, Mungall AJ, Griffiths-Jones S, Smith P, Beury D, Matthews L, Rogers J, Pask AJ, Shaw G, VandeBerg JL, McCarrey JR, Renfree MB, Reik W, DunhamI (2008) Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians. Nature Genetics40, 971-976
^Murrell A, Heeson S, Reik W (2004) Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops. Nature genetics36, 889-893
^Constância, Miguel; Hemberger, Myriam; Hughes, Jennifer; Dean, Wendy; Ferguson-Smith, Anne; Fundele, Reinald; Stewart, Francesca; Kelsey, Gavin; Fowden, Abigail; Sibley, Colin; Reik, Wolf (2002). "Placental-specific IGF-II is a major modulator of placental and fetal growth". Nature. 417 (6892): 945–948. doi:10.1038/nature00819. ISSN0028-0836. PMID12087403. S2CID4421165. (subscription required)
