Flubendazole is an anthelmintic, used both in humans and for veterinarian purposes. It is very close chemically to mebendazole, the only difference being an added fluorine group.[2]
Human use
It is available for human use to treat worm infections. In certain countries such as France, it is inexpensive and available OTC (without prescription)[3] under the brand name Fluvermal as an alternative to mebendazole which is not currently sold there.[4]
Veterinarian use
Under veterinary use, its brand name is Flutelmium which is a paste manufactured by Janssen Pharmaceutica N.V. used by veterinarians for protection against internal parasites and worms in dogs and cats. Other brand names are Flubenol, Biovermin, and Flumoxal.[5]
Since 2000, Flubendazole-treated grit has increasingly been laid out on a landscape-scale across many UK grouse-shooting moors by gamekeepers in an attempt to reduce the impact on bird numbers from strongyle worm. Evidence of high worm burden is required before a veterinarian can dispense and sell the product, known as 'medicated grit'.[6] However, there has been increasing concern about contaminants entering the ground waters running off from moorlands, as well as from its use in farming environments and its presence in manure. Researchers are starting to gather research evidence in order to inform policy development on the presence of this and other veterinary medicines in the wider environment.[7][8]
References
^ abVasilev NA, Voronin AP, Surov AO, Perlovich GL (March 2023). "Influence of Co-amorphization on the Physical Stability and Dissolution Performance of an Anthelmintic Drug Flubendazole". Molecular Pharmaceutics. 20 (3): 1657–1669. doi:10.1021/acs.molpharmaceut.2c00873. PMID36732935. S2CID256546280.
