DOTMA

DOTMA
Clinical data
Other names2,5-Dimethoxy-3,4,6-trimethylamphetamine; Julia; 3,6-Dimethyl-DOM; 6-Methyl-Ganesha
Routes of
administration		Oral[1]
Drug classSerotonergic psychedelic; Hallucinogen
ATC code
  • None
Pharmacokinetic data
Duration of action7–9 hours[1]
Identifiers
  • 1-(2,5-dimethoxy-3,4,6-trimethylphenyl)propan-2-amine
Chemical and physical data
FormulaC14H23NO2
Molar mass237.343 g·mol−1
3D model (JSmol)
  • COc1c(C)c(CC(N)C)c(c(c1C)C)OC
  • InChI=1S/C14H23NO2/c1-8(15)7-12-11(4)13(16-5)9(2)10(3)14(12)17-6/h8H,7,15H2,1-6H3
  • Key:ROGMRKPRWZWOSW-UHFFFAOYSA-N

DOTMA, also known as 2,5-dimethoxy-3,4,6-trimethylamphetamine or as Julia, is a psychedelic drug of the phenethylamine, amphetamine, and DOx families related to DOM.[1] It is the 3,6-dimethyl derivative of DOM and the 6-methyl derivative of Ganesha.[1] The drug is said to be the first and only known active phenethylamine psychedelic with a fully substituted phenyl ring.[1] However, the cyclized FLY phenethylamines such as 2C-B-FLY also have a fully substituted phenyl ring.[1]

DOTMA's dose is approximately 70 mg orally and its duration is 7 to 9 hours.[1] It is less potent than DOM, which is active at doses of 3 to 10 mg, and has a shorter duration than DOM, which lasts 14 to 20 hours.[1] Similarly, DOTMA is less potent and shorter-acting than Ganesha, which has a dose of 20 to 32 mg and a duration of 18 to 24 hours.[1]

DOTMA was described in the scientific literature by Daniel Trachsel in 2013.[1] The 6-methyl-DOM analogue of DOTMA and Ganesha, Juno, is relatively unknown but may be an active psychedelic as well.[1] DOTMA, or Julia, is closely related to Alexander Shulgin's "ten classic ladies".[2][3] It is a controlled substance in Canada due to phenethylamine blanket-ban language[4] but is not explicitly controlled in the United States.[5]

See also

References

  1. ^ a b c d e f g h i j k Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. pp. 936–937. ISBN 978-3-03788-700-4. OCLC 858805226. Archived from the original on 21 August 2025.
  2. ^ Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628.
  3. ^ Ger A, Ger D. "Triple Goddess of the Night". British Neuroscience Association Bulletin. 63: 28–30.
  4. ^ "Controlled Drugs and Substances Act". Department of Justice Canada. 5 December 2025. Retrieved 20 January 2026.
  5. ^ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
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