DEFB127

DEFB127

Identifiers

DEFB127, C20orf73, DEF-27, DEFB-27, DEFB27, bA530N10.2, hBD-27, defensin beta 127

External IDs

HomoloGene: 89142; GeneCards: DEFB127; OMA:DEFB127 - orthologs

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	20p13	Start	157,454 bp^[1]
Band	20p13	End	159,163 bp^[1]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

corpus epididymis

tail of epididymis

testicle

caput epididymis

mucosa of ileum

kidney

human kidney

skin of abdomen

n/a

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	extracellular region cell surface cellular component
Biological process	defense response defense response to bacterium innate immune response antimicrobial humoral immune response mediated by antimicrobial peptide
Sources:Amigo / QuickGO

Species

Human

Mouse


140850


n/a


ENSG00000088782


n/a


Q9H1M4


n/a

RefSeq (mRNA)


NM_139074


n/a

RefSeq (protein)


NP_620713


n/a

Location (UCSC)

Chr 20: 0.16 – 0.16 Mb

n/a

PubMed search

^[2]

n/a

View/Edit Human

Beta-defensin 127 is a protein that in humans is encoded by the DEFB127 gene.^[3]^[4]

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000088782 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. Bibcode:2002PNAS...99.2129S. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.
^ ^a ^b "Entrez Gene: DEFB127 defensin, beta 127".

Further reading

van Wetering S, Sterk PJ, Rabe KF, Hiemstra PS (2000). "Defensins: key players or bystanders in infection, injury, and repair in the lung?". J. Allergy Clin. Immunol. 104 (6): 1131–8. doi:10.1016/S0091-6749(99)70004-7. PMID 10588992.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Rodríguez-Jiménez FJ, Krause A, Schulz S, et al. (2003). "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis". Genomics. 81 (2): 175–83. doi:10.1016/S0888-7543(02)00034-4. PMID 12620395.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.

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