ADAM2

ADAM2
Identifiers
AliasesADAM2, CRYN1, CRYN2, CT15, FTNB, PH-30b, PH30, PH30-beta, ADAM metallopeptidase domain 2
External IDsOMIM: 601533; MGI: 1340894; HomoloGene: 1127; GeneCards: ADAM2; OMA:ADAM2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

2515

11495

Ensembl

ENSG00000104755
ENSG00000276286

ENSMUSG00000022039

UniProt

Q99965

Q60718

RefSeq (mRNA)

NM_001278113
NM_001278114
NM_001464

NM_009618

RefSeq (protein)

NP_001265042
NP_001265043
NP_001455

NP_033748

Location (UCSC)Chr 8: 39.74 – 39.84 MbChr 14: 66.26 – 66.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 2 or Beta-fertilin[5] is an enzyme that in humans is encoded by the ADAM2 gene.[6][7][8]

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane heterodimer glycoprotein called fertilin, which plays an important role in sperm-egg interactions.[8] The other subunit is ADAM1 or alpha-fertilin.[5]

References

  1. ^ a b c ENSG00000276286 GRCh38: Ensembl release 89: ENSG00000104755, ENSG00000276286 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022039 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Fàbrega A, Guyonnet B, Dacheux JL, Gatti JL, Puigmulé M, Bonet S, Pinart E (June 2011). "Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (Sus domesticus) spermatozoa during epididymal maturation". Reproductive Biology and Endocrinology. 9 96. doi:10.1186/1477-7827-9-96. PMC 3141649. PMID 21718510.
  6. ^ Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF (July 1996). "Molecular cloning of the human fertilin beta subunit". Biochemical and Biophysical Research Communications. 224 (2): 318–26. Bibcode:1996BBRC..224..318G. doi:10.1006/bbrc.1996.1027. PMID 8702389.
  7. ^ Burkin HR, Burkin DJ, Davey PM, Griffin DK, Affara NA (February 1997). "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB)". Genomics. 40 (1): 190–2. doi:10.1006/geno.1996.4531. PMID 9070941.
  8. ^ a b "Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)".

Further reading


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