The 2020–21 SC Paderborn 07 season was the 114th edition of SC Paderborn 07's existence, the club's first season return in the 2. Bundesliga, the second tier of Germany football, following their promotion from the 3. Liga in the 2020–21 season. The club contested in the DFB-Pokal. The season covered the period from 1 July 2020 to 30 June 2021.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
^The SC Wiedenbrück v SC Paderborn match took place at the Heidewald Stadion in Gütersloh instead of SC Wiedenbrück's home stadium, the Jahnstadion in Rheda-Wiedenbrück.