February 5 – James Stanhope, chief minister of Great Britain, dies a day after collapsing while vigorously defending his government's conduct over the "South Sea Bubble" in Parliament.
April 21 – The deadliest outbreak of smallpox in the history of Boston begins when the British ship HMS Sea Horse arrives in Boston Harbor with a crew of sailors who had survived a smallpox epidemic. One of the Seahorse crew who had cleared quarantine develops symptoms the next day and infects other people in a lodging house. Over the next 10 months, 5,759 cases of smallpox are recorded in Boston and 844 people die of the disease.
June 26 – Dr. Zabdiel Boylston of the Harvard University School of Medicine begins the first public inoculation campaign in order to slow the smallpox epidemic in Boston, giving a vaccine to his own son, and then to his slave and the slave's infant son. [4]
July –September
July 31 – The Spanish expedition led by Coahuila Governor José de Azlor y Virto de Vera, sent to recapture Texas from the French, encounters Neches River the smaller French force of Louis Juchereau de St. Denis, who had led the French expansion westward from the Louisiana territory. Realizing that his forces are badly outnumbered, St. Denis abandons hope of colonizing the east Texas territory and Azlor retakes the area. [5]
^Frank Sherry, Raiders and Rebels: The Golden Age of Piracy (Quill, 1986) p15
^Breverton, Terry (2004). Black Bart Roberts: The Greatest Pirate of Them All. Gretna, LA: Pelican Publishing. p. 57. ISBN1-58980-233-0.
^"The Boston Inoculation Controversy of 1721-1722: An Incident in the History of Race", by Margo Minardi, The William and Mary Quarterly (January 2004)
^John L. Kessell, Spain in the Southwest: A Narrative History of Colonial New Mexico, Arizona, Texas, and California (University of Oklahoma Press, 2013) p217
^Clear, Todd R.; Cole, George F.; Resig, Michael D. (2006). American Corrections (7th ed.). Thompson.