TPA

TPA
Identifikatori
Aliasi
Vanjski ID-jeviGeneCards: [1]
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

n/a

n/a

RefSeq (bjelančevina)

n/a

n/a

Lokacija (UCSC)n/an/a
PubMed pretragan/an/a
Wikipodaci
Pogledaj/uredi – čovjek

Tonsokuiliki protein popravljanja oštećene DNK je protein koji je kod ljudi kodiran genom TONSL.[1]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.378 aminokiselina, а molekulska težina 150.929 Da.[2]

1020304050
MSLERELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGRYAEALEQH
WQELQLRERADDPLGCAVAHRKIGERLAEMEDYPAALQHQHQYLELAHSL
RNHTELQRAWATIGRTHLDIYDHCQSRDALLQAQAAFEKSLAIVDEELEG
TLAQGELNEMRTRLYLNLGLTFESLQQTALCNDYFRKSIFLAEQNHLYED
LFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFMESECCVVIAQ
VLQDLGDFLAAKRALKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLE
EAEGRDPQGAMVICEQLGDLFSKAGDFPRAAEAYQKQLRFAELLDRPGAE
RAIIHVSLATTLGDMKDHHGAVRHYEEELRLRSGNVLEEAKTWLNIALSR
EEAGDAYELLAPCFQKALSCAQQAQRPQLQRQVLQHLHTVQLRLQPQEAP
ETETRLRELSVAEDEDEEEEAEEAAATAESEALEAGEVELSEGEDDTDGL
TPQLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVR
QGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGIT
PLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLD
LETRQKARAMEMLLQAAASGQDPHSSQAFHTPSSLLFDPETSPPLSPCPE
PPSNSTRLPEASQAHVRVSPGQAAPAMARPRRSRHGPASSSSSSEGEDSA
GPARPSQKRPRCSATAQRVAAWTPGPASNREAATASTSRAAYQAAIRGVG
SAQSRLGPGPPRGHSKALAPQAALIPEEECLAGDWLELDMPLTRSRRPRP
RGTGDNRRPSSTSGSDSEESRPRARAKQVRLTCMQSCSAPVNAGPSSLAS
EPPGSPSTPRVSEPSGDSSAAGQPLGPAPPPPIRVRVQVQDHLFLIPVPH
SSDTHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDLIPDVLQSN
DEVLAEVTSWDLPPLTDRYRRACQSLGQGEHQQVLQAVELQGLGLSFSAC
SLALDQAQLTPLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMPSL
ALLDLSSNHLGPEGLRQLAMGLPGQATLQSLEELDLSMNPLGDGCGQSLA
SLLHACPLLSTLRLQACGFGPSFFLSHQTALGSAFQDAEHLKTLSLSYNA
LGAPALARTLQSLPAGTLLHLELSSVAAGKGDSDLMEPVFRYLAKEGCAL
AHLTLSANHLGDKAVRDLCRCLSLCPSLISLDLSANPEISCASLEELLST
LQKRPQGLSFLGLSGCAVQGPLGLGLWDKIAAQLRELQLCSRRLCAEDRD
ALRQLQPSRPGPGECTLDHGSKLFFRRL

Funkcija

Smatra se da je protein kodiran ovim genom negativan regulator NF-kappa-B posredovane transkripcije. Kodirani protein može vezati komplekse NF-kappa-B i zarobiti ih u citoplazmi, sprječavajući ih da uđu u jedro i stupe u interakciju s DNK. Fosforilacija ovog proteina cilja ga na razgradnju putem ubikvitinacije, što oslobađa komplekse NF-kappa-B da uđu u ćelijsko jedro.

Reference

  1. ^ "Entrez Gene: Tonsoku-like, DNA repair protein".
  2. ^ "UniProt, Q96HA7" (jezik: engleski). Pristupljeno 22. 9. 2021.

Dopunska literatura

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