DOKUMEN123.COM

PRB4
Identifikatori
Aliasi	PRB4
Vanjski ID-jevi	OMIM: 180990 GeneCards: PRB4
Lokacija gena (čovjek)
Hrom.	Hromosom 12 (čovjek)
Kraj	11,310,436 bp
Ontologija gena
Molekularna funkcija	• molekularna funkcija;
Ćelijska komponenta	• extracellular region;
Biološki proces	• GO:0022610 biološki proces;
	Izvori:Amigo / QuickGO
Ortolozi
	5545
	n/a
	ENSG00000274839; ENSG00000230657
	n/a
	P10163
	n/a
	NM_002723; NM_001261399
	n/a
	n/a
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Bazni pljuvačni prolinom bogati protein 4 je protein koji je kod ljudi kodiran genom PRB4.^[3]

Protein kodiran ovim genom spada upljuvačne proteine bogate prolinom. Ovaj i pet drugih gena koji također kodiraju pljuvačni proteine bogate prolinom (PRP), kao i gen koji kodira suznu žlijezdu PRP, čine PRP genski klaster u regiji 12p13 hromosoma 12.^[3]

PRB4 se posttranslacijski cijepa na tri različita zrela peptida:

Protein N1
Glikozilirani protein A
Peptid P-D (poznat i kao Peptid IB-5 bogat prolinom)

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 310 aminokiselina, a molekulska težina 31 326 Da.^[4]

10	20	30	40	50
MLLILLSVAL	LALSSAESSS	EDVSQEESLF	LISGKPEGRR	PQGGNQPQRP
PPPPGKPQGP	PPQGGNQSQG	PPPPPGKPEG	RPPQGGNQSQ	GPPPHPGKPE
RPPPQGGNQS	QGPPPHPGKP	ESRPPQGGHQ	SQGPPPTPGK	PEGPPPQGGN
QSQGTPPPPG	KPEGRPPQGG	NQSQGPPPHP	GKPERPPPQG	GNQSHRPPPP
PGKPERPPPQ	GGNQSQGPPP	HPGKPEGPPP	QEGNKSRSAR	SPPGKPQGPP
QQEGNKPQGP	PPPGKPQGPP	PAGGNPQQPQ	APPAGKPQGP	PPPPQGGRPP
RPAQGQQPPQ

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

^ ^a ^b ^c ENSG00000230657 GRCh38: Ensembl release 89: ENSG00000274839, ENSG00000230657 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: PRB4 proline-rich protein BstNI subfamily 4".
^ "UniProt, P10163". Pristupljeno 13. 8. 2021.

Dopunska literatura

Azen EA, Maeda N (1988). "Molecular genetics of human salivary proteins and their polymorphisms". Adv. Hum. Genet. 17: 141–99. doi:10.1007/978-1-4613-0987-1_5. ISBN 978-1-4612-8279-2. PMID 3055850.
Bennick A (1982). "Salivary proline-rich proteins". Mol. Cell. Biochem. 45 (2): 83–99. doi:10.1007/BF00223503. PMID 6810092. S2CID 31373141.
Lyons KM, Stein JH, Smithies O (1989). "Length Polymorphisms in Human Proline-Rich Protein Genes Generated by Intragenic Unequal Crossing over". Genetics. 120 (1): 267–78. doi:10.1093/genetics/120.1.267. PMC 1203497. PMID 2851479.
Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. doi:10.1016/S0021-9258(17)39156-1. PMID 2993301.
Lyons KM, Azen EA, Goodman PA, Smithies O (1989). "Many Protein Products from a Few Loci: Assignment of Human Salivary Proline-Rich Proteins to Specific Loci". Genetics. 120 (1): 255–65. doi:10.1093/genetics/120.1.255. PMC 1203496. PMID 3220251.
Warner TF, Azen EA (1984). "Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract". Am. Rev. Respir. Dis. 130 (1): 115–8. doi:10.1164/arrd.1984.130.1.115 (neaktivno 31. 5. 2021). PMID 6377992.CS1 održavanje: DOI nije aktivan od 2021 (link)
Saitoh E, Isemura S, Sanada K (1983). "Complete amino acid sequence of a basic proline-rich peptide, P-D, from human parotid saliva". J. Biochem. 93 (2): 495–502. doi:10.1093/jb/93.3.883. PMID 6841349.
Kauffman DL, Keller PJ, Bennick A, Blum M (1993). "Alignment of amino acid and DNA sequences of human proline-rich proteins". Crit. Rev. Oral Biol. Med. 4 (3–4): 287–92. doi:10.1177/10454411930040030501. PMID 8373986.
Kim HS, Lyons KM, Saitoh E, et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome. 4 (1): 3–14. doi:10.1007/BF00364656. PMID 8422499. S2CID 24058984.
Azen EA, Amberger E, Fisher S, et al. (1996). "PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins". Am. J. Hum. Genet. 58 (1): 143–53. PMC 1914931. PMID 8554050.
Castle AM, Castle JD (1998). "Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein". Mol. Biol. Cell. 9 (3): 575–83. doi:10.1091/mbc.9.3.575. PMC 25286. PMID 9487127.
Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. doi:10.1046/j.1432-1327.2001.02241.x. PMID 11422372.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Vallat JM, Magy L, Lagrange E, et al. (2007). "Diagnostic value of ultrastructural nerve examination in Charcot-Marie-Tooth disease: two CMT 1B cases with pseudo-recessive inheritance". Acta Neuropathol. 113 (4): 443–9. doi:10.1007/s00401-007-0196-7. PMID 17294201. S2CID 42561185.

[refGRCh38Ensembl-1] ENSG00000230657 GRCh38: Ensembl release 89: ENSG00000274839, ENSG00000230657 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: PRB4 proline-rich protein BstNI subfamily 4".

[UniProt-4] "UniProt, P10163". Pristupljeno 13. 8. 2021.

[1]

[2]

[3]

[4]

PRB4

Aminokiselinska sekvenca

Reference

Dopunska literatura

Content Disclaimer