PRB1

PRB1
Identifikatori
AliasiPRB1
Vanjski ID-jeviOMIM: 180989 MGI: 1924007 GeneCards: PRB1
Lokacija gena (čovjek)
Hromosom 12 (čovjek)
Hrom.Hromosom 12 (čovjek)[1]
Hromosom 12 (čovjek)
Genomska lokacija za PRB1
Genomska lokacija za PRB1
Bend12p13.2Početak11,351,823 bp[1]
Kraj11,355,591 bp[1]
Lokacija gena (miš)
Hromosom 10 (miš)
Hrom.Hromosom 10 (miš)[2]
Hromosom 10 (miš)
Genomska lokacija za PRB1
Genomska lokacija za PRB1
Bend10|10 A4Početak32,956,550 bp[2]
Kraj33,352,705 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija molekularna funkcija
Ćelijska komponenta extracellular region
Biološki proces GO:0022610 biološki proces
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_199354
NM_005039
NM_199353
NM_001367912

NM_029726
NM_001364696
NM_001364697

RefSeq (bjelančevina)

NP_005030
NP_001354841

NP_084002
NP_001351625
NP_001351626

Lokacija (UCSC)Chr 12: 11.35 – 11.36 MbChr 10: 32.96 – 33.35 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Bazni pljuvačni prolinom bogati protein 1 je protein koji je kod ljudi kodiran genom PRB1.[5][6]

Protein kodiran ovim genom je prolinom bogat pljuvačni protein. Ovaj i pet drugih gena koji također kodiraju pljuvačne prolinom bogate proteine (PRP), kao i gen koji kodira suznu žlijezdu PRP, tvore PRP genski klaster u regiji p13 hromosoma 12. Opisane su alternativno prerađene varijante transkripta koje kodiraju različite izoforme.[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 392 aminokiseline, a molekulska težina 38.546 Da.[7]

1020304050
MLLILLSVALLALSSAQNLNEDVSQEESPSLIAGNPQGPSPQGGNKPQGP
PPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGP
PPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSQS
PRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ
GPPPQGDKSQSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPQQGGNR
PQGPPPPGKPQGPPPQGDKSRSPQSPPGKPQGPPPQGGNQPQGPPPPPGK
PQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARAPPGKPQGPPQQEG
NNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRPPQ
Simboli

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000251655 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019787 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Azen EA, Latreille P, Niece RL (Jul 1993). "PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs)". Am J Hum Genet. 53 (1): 264–78. PMC 1682219. PMID 8317492.
  6. ^ a b "Entrez Gene: PRB1 proline-rich protein BstNI subfamily 1".
  7. ^ "UniProt, P04280". Pristupljeno 13. 8. 2021.

Dopunska literatura

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