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ESF1
Identifikatori
Aliasi	ESF1
Vanjski ID-jevi	MGI: 1913830 HomoloGene: 5717 GeneCards: ESF1
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	13,784,919 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	140,012,484 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa RNK;
Ćelijska komponenta	• Jedarce; • jedro; • nukleoplazma; • Vanćelijsko;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • rRNA processing;
	Izvori:Amigo / QuickGO
Ortolozi
	51575
	66580
	ENSG00000089048
	ENSMUSG00000045624
	Q9H501
	Q3V1V3
	NM_016649; NM_001276380
	NM_001081090
	NP_001263309; NP_057733
	NP_001074559
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Homolog ESF1 je protein koji je kod ljudi kodiran genom ESF1.^[5]

Funkcija

Oda et al. (2004) otkrili su da je pacovski Abtap komunicirao s Abt1 miša (618750) i potiskivao transkripciju induciranu Abt1 inhibiranjem vezanja između Abt1 i Tbp (600075) na način koji ovisi o dozi.^[6] Pacov Abtap i miš Abt1 gotovo su se potpuno kolokalizirali kada su kotransticirani u ćelijama COS7. Međutim, subjedarna lokalizacija kompleksa Abt1 / Abtap regulirana je relativnom količinom svakog proteina u ćelijama. Kada je Abtap bio dominantan, oba proteina su bila lokalizirana u jedatnim tijelima, gdje je bio lokaliziran samo Abtap. Kada je Abt1 bio dominantan, oba proteina su se lokalizirala u nukleolusu i nukleoplazmi, gdje je bio samo Abt1. Koristeći analizu osiromašenja, Peng et al (2004) otkrili su da je Esf1 potreban za sintezu 18S rRNK i za obradu pre-rRNK u S. cerevisiae. Analiza čišćenja pokazala je da se Esf1 fizički povezuje sa ribosomnim proteinima, proteinima potrebnim za biogenezu malih podjedinica i snoRNK U3 (180710) i U14. Iscrpljivanje Esf1 nije utjecalo na biogenezu ili stabilnost snoRNK.^[7]

Životinjski model

Koristeći fluorescentnu in situ hibridizaciju, Chen et al. (2018) ^[8] pokazali su da je mRNK ESF1-a eksprimirana u ždrijelnim lukovima i neuroepitelu zebrica. Homozigotne zebrice za krnji protein esf1 imale su oštećene hrskavice ždrijelnih lukova, uslijed povećane apoptoze ćelija nervnog grebena (NCC) u kranijskom živčanom grebenu i umrli su oko šest dana nakon oplodnje. Ekspresija divljeg tipa ESFN1 pune dužine održala je fenotip i obnovila formiranje hrskavica ždrijelnog luka. Povećana apoptozna oštećenja i hrskavice u mutiranih riba djelimično su posredovana preko regulirane signalizacije p53 (TP53; 191170). Esf1 je imao ulogu u migraciji, preživljavanju i diferencijaciji nervnog grebena, djelujući u NCC-ima na ćelijski-autonomni način. Ribe sa mutiranim esf1 također su pokazale nedostatke u biogenezi 18S rRNK i biogenezi ribosoma.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089048 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045624 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)".
^ Oda, T., Fukuda, A., Hagiwara, H., Masuho, Y., Muramatsu, M., Hisatake, K.k, Yamashita, T. ABT1-associated protein (ABTAP), a novel nuclear protein conserved from yeast to mammals, represses transcriptional activation by ABT1. J. Cell. Biochem. 93: 788-806, 2004. PubMed: 15660422
^ Peng, W.-T., Krogan, N. J., Richards, D. P., Greenblatt, J. F., Hughes, T. R. ESF1 is required for 18S rRNA synthesis in Saccharomyces cerevisiae. Nucleic Acids Res. 32: 1993-1999, 2004. PubMed: 15056729
^ Chen, J.-Y., Tan, X., Wang, Z.-H., Liu, Y.-Z., Zhou, J.-F., Rong, X.-Z., Lu, L., Li, Y. The ribosome biogenesis protein Esf1 is essential for pharyngeal cartilage formation in zebrafish. FEBS J. 285: 3464-3484, 2018. PubMed: 30073783

Dopunska literatura

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Oda T, Fukuda A, Hagiwara H, et al. (2005). "ABT1-associated protein (ABTAP), a novel nuclear protein conserved from yeast to mammals, represses transcriptional activation by ABT1". J. Cell. Biochem. 93 (4): 788–806. doi:10.1002/jcb.20114. PMID 15660422. S2CID 25575472.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Huang L, Feng L, Yang L, et al. (2003). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Mol. Biol. Rep. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424. S2CID 22611084.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000089048 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045624 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)".

[6] Oda, T., Fukuda, A., Hagiwara, H., Masuho, Y., Muramatsu, M., Hisatake, K.k, Yamashita, T. ABT1-associated protein (ABTAP), a novel nuclear protein conserved from yeast to mammals, represses transcriptional activation by ABT1. J. Cell. Biochem. 93: 788-806, 2004. PubMed: 15660422

[7] Peng, W.-T., Krogan, N. J., Richards, D. P., Greenblatt, J. F., Hughes, T. R. ESF1 is required for 18S rRNA synthesis in Saccharomyces cerevisiae. Nucleic Acids Res. 32: 1993-1999, 2004. PubMed: 15056729

[8] Chen, J.-Y., Tan, X., Wang, Z.-H., Liu, Y.-Z., Zhou, J.-F., Rong, X.-Z., Lu, L., Li, Y. The ribosome biogenesis protein Esf1 is essential for pharyngeal cartilage formation in zebrafish. FEBS J. 285: 3464-3484, 2018. PubMed: 30073783

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ESF1

Funkcija

Životinjski model

Reference

Dopunska literatura

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