ARFIP2

ARFIP2
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1I49, 1I4D, 1I4L, 1I4T, 4DCN

Identifikatori
AliasiARFIP2
Vanjski ID-jeviOMIM: 601638 MGI: 1924182 HomoloGene: 8234 GeneCards: ARFIP2
Lokacija gena (čovjek)
Hromosom 11 (čovjek)
Hrom.Hromosom 11 (čovjek)[1]
Hromosom 11 (čovjek)
Genomska lokacija za ARFIP2
Genomska lokacija za ARFIP2
Bend11p15.4Početak6,474,683 bp[1]
Kraj6,481,479 bp[1]
Lokacija gena (miš)
Hromosom 7 (miš)
Hrom.Hromosom 7 (miš)[2]
Hromosom 7 (miš)
Genomska lokacija za ARFIP2
Genomska lokacija za ARFIP2
Bend7|7 E3Početak105,283,410 bp[2]
Kraj105,289,623 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija phosphatidylinositol-4-phosphate binding
protein domain specific binding
GO:0001948, GO:0016582 vezivanje za proteine
GTP binding
vezivanje identičnih proteina
cadherin binding
GTP-dependent protein binding
phospholipid binding
Ćelijska komponenta cell cortex
trans-Golgi network membrane
ćelijska membrana
ruffle
citosol
citoplazma
Biološki proces ruffle organization
small GTPase mediated signal transduction
actin cytoskeleton organization
regulation of Arp2/3 complex-mediated actin nucleation
lamellipodium assembly
intracellular protein transport
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001242854
NM_001242855
NM_001242856
NM_012402

NM_029802

RefSeq (bjelančevina)
NP_001229783
NP_001229784
NP_001229785
NP_036534
NP_001357335

NP_001357337
NP_001357338
NP_001357340
NP_001357341
NP_001357342
NP_001363487
NP_001363488
NP_001363489
NP_001363490
NP_001363491
NP_001363492
NP_001363493

NP_084078

Lokacija (UCSC)Chr 11: 6.47 – 6.48 MbChr 7: 105.28 – 105.29 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Arfaptin-2 je protein koji je kod ljudi kodiran genom ARFIP2.[5][6][7]

Interakcije

Pokazano je da ARFIP2 imainterakcije sa Arf6,[8][9] ARF3,[6] ARF5[6][9] i RAC1.[5][9][10]

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132254 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030881 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Van Aelst L, Joneson T, Bar-Sagi D (august 1996). "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15): 3778–86. doi:10.1002/j.1460-2075.1996.tb00751.x. PMC 452058. PMID 8670882.
  6. ^ a b c Kanoh H, Williger BT, Exton JH (februar 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.
  7. ^ "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)".
  8. ^ D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (septembar 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
  9. ^ a b c Shin OH, Exton JH (august 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
  10. ^ Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (maj 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801.

Dopunska literatura

Vanjski linkovi

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