NADH-cytochrome b5 reductase 1 là enzyme ở người được mã hóa bởi genCYB5R1.[2][3][4]
Cấu trúc
Gen CYB5R1 nằm trên nhiễm sắc thể 1, với vị trí đặc hiệu 1q32.1. Gen có 9 exon.[4] CYB5R1 mã hóa cho một protein nặng 34,1 kDa cấu thành từ 305 amino acid; 56 peptide đã được phát hiện từ dữ liệu khối phổ.[5][6]
^Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (tháng 10 năm 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. Quyển 13 số 10. tr. 2265–70. doi:10.1101/gr.1293003. PMC403697. PMID12975309.
^Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF (tháng 12 năm 1999). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proceedings of the National Academy of Sciences of the United States of America. Quyển 96 số 26. tr. 14742–7. doi:10.1073/pnas.96.26.14742. PMC24718. PMID10611283.
^Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (tháng 10 năm 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. Quyển 113 số 9. tr. 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC4076475. PMID23965338.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. Quyển 12 số 2. tr. 117–26. doi:10.1093/dnares/12.2.117. PMID16303743.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (tháng 10 năm 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. Quyển 437 số 7062. tr. 1173–8. doi:10.1038/nature04209. PMID16189514.
Qian W, Sun YL, Wang YH, Zhuang JH, Xie Y, Huang ZX (tháng 10 năm 1998). "The influence of mutation at Glu44 and Glu56 of cytochrome b5 on the protein's stabilization and interaction between cytochrome c and cytochrome b5". Biochemistry. Quyển 37 số 40. tr. 14137–50. doi:10.1021/bi9805036. PMID9760250.
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