TDO2

TDO2
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген TDO2[d][1]
Молекуляр функция oxygen binding[d][2], oxidoreductase activity[d][2], связывание с белками плазмы[d][3][4][5], dioxygenase activity[d][2], amino acid binding[d][2], связывание с ионом металла[d][2][2], связывание похожих белков[d][3], tryptophan 2,3-dioxygenase activity[d][6][7][6][…], heme binding[d][6][6][6][…], tryptophan 2,3-dioxygenase activity[d][8][2][2][…] һәм heme binding[d][2][2][2][…]
Күзәнәк компоненты цитозоль[d][2]
Биологик процесс tryptophan catabolic process[d][2][2], tryptophan catabolic process to acetyl-CoA[d][2][9], tryptophan metabolic process[d][2], tryptophan catabolic process to kynurenine[d][2][2][10], protein homotetramerization[d][10][11] һәм response to nitroglycerin[d][2]
Изображение Gene Atlas
 TDO2 Викиҗыентыкта

TDO2 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[12][13]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 GOA
  3. ↑ 3,0 3,1 Dricot A., Barabási A., Tavernier J. et al. A proteome-scale map of the human interactome network // Cell — Cell Press, Elsevier, 2014. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2014.10.050 — PMID:25416956
  4. ↑ Barabási A., Taipale M., Weile J. et al. Widespread macromolecular interaction perturbations in human genetic disorders // Cell — Cell Press, Elsevier, 2015. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2015.04.013 — PMID:25910212
  5. ↑ Bosak S., Hirozane-Kishikawa T., Dricot A. et al. Towards a proteome-scale map of the human protein–protein interaction network, Towards a proteome-scale map of the human protein-protein interaction network // Nature / M. Skipper — NPG, Springer Science+Business Media, 2005. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE04209 — PMID:16189514
  6. ↑ 6,0 6,1 6,2 6,3 6,4 GOA
  7. ↑ Comings D. E., D. Muhleman, G. Dietz et al. Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat // Genomics / A. Engel — Academic Press, Elsevier, 1995. — ISSN 0888-7543; 1089-8646 — doi:10.1006/GENO.1995.9990 — PMID:8666386
  8. ↑ Comings D. E., D. Muhleman, G. Dietz et al. Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat // Genomics / A. Engel — Academic Press, Elsevier, 1995. — ISSN 0888-7543; 1089-8646 — doi:10.1006/GENO.1995.9990 — PMID:8666386
  9. ↑ Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  10. ↑ 10,0 10,1 Forouhar F., Correia M. A. Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase // Sci. Rep. — Macmillan Publishers, NPG, 2016. — ISSN 2045-2322 — doi:10.1038/SREP35169 — PMID:27762317
  11. ↑ Dornevil K., Liu A., Dewey D. et al. Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency // Molecular Genetics and Metabolism — Elsevier, 2017. — ISSN 1096-7192; 1096-7206 — doi:10.1016/J.YMGME.2017.02.009 — PMID:28285122
  12. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  13. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)


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