SEMA4D

SEMA4D
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген SEMA4D[d][1]
Молекуляр функция signaling receptor binding[d][2][3][4], transmembrane signaling receptor activity[d][3], связывание с белками плазмы[d][3], semaphorin receptor binding[d][5][6][5], neuropilin binding[d][7], связывание похожих белков[d][8], signaling receptor activity[d][9], semaphorin receptor binding[d][2][10][2][…] һәм chemorepellent activity[d][7]
Күзәнәк компоненты мембрана өлеше[d][2], күзәнәк мембранасы өлеше[d][11], мембрана[d][2], күзәнәк мембранасы[d][2][2], күзәнәк тышындагы мохит[d][2][2][7] һәм күзәнәк мембранасы өлеше[d][12][7]
Биологик процесс regulation of dendrite morphogenesis[d][13], негативная регуляция апоптоза[d][12], positive regulation of phosphatidylinositol 3-kinase signaling[d][14], развитие многоклеточного организма[d][2], leukocyte aggregation[d][12], нерв системасы үсеше[d][2], negative regulation of cell adhesion[d][10], positive regulation of peptidyl-tyrosine phosphorylation[d][2][2], positive regulation of axonogenesis[d][2], semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis[d][2][2], regulation of cell projection organization[d][3], negative regulation of osteoblast differentiation[d][2][2], positive regulation of collateral sprouting[d][13], regulation of cell shape[d][3], negative regulation of peptidyl-tyrosine phosphorylation[d][2][2], дифференцировка клеток[d][2], positive regulation of protein phosphorylation[d][14], semaphorin-plexin signaling pathway[d][8][15][6], агрегация клеток[d][12], иммун җавап[d][12], ossification involved in bone maturation[d][16][2], positive regulation of cell migration[d][5][5][17], negative regulation of transcription by RNA polymerase II[d][16][2], positive regulation of GTPase activity[d][2][13][2], negative regulation of alkaline phosphatase activity[d][16][2], negative chemotaxis[d][7], neural crest cell migration[d][7], positive regulation of cell migration[d][2][2][14][…], negative regulation of axon extension involved in axon guidance[d][7], semaphorin-plexin signaling pathway[d][13][3][10][…], positive regulation of inhibitory synapse assembly[d][2][2], negative regulation of transcription by RNA polymerase II[d][16][2][7], negative regulation of alkaline phosphatase activity[d][16][2][7], positive regulation of GTPase activity[d][2][13][2][…] һәм ossification involved in bone maturation[d][16][2][7]

SEMA4D (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[18][19]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 2,19 2,20 2,21 2,22 2,23 2,24 2,25 2,26 2,27 2,28 2,29 2,30 2,31 2,32 2,33 2,34 GOA
  3. ↑ 3,0 3,1 3,2 3,3 3,4 3,5 Bert J C Janssen, Mitchell K. J., Jones Y. et al. Structural basis of semaphorin-plexin signalling // Nature / M. Skipper — NPG, Springer Science+Business Media, 2010. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE09468 — PMID:20877282
  4. ↑ S Delaire, C Billard, R Tordjman et al. Biological activity of soluble CD100. II. Soluble CD100, similarly to H-SemaIII, inhibits immune cell migration // J. Immunol. — Baltimore: 2001. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.166.7.4348 — PMID:11254688
  5. ↑ 5,0 5,1 5,2 5,3 GOA
  6. ↑ 6,0 6,1 Gilestro G. F., Comoglio P. M., Tamagnone L. et al. Plexin-B3 is a functional receptor for semaphorin 5A. // EMBO Rep. — NPG, 2004. — ISSN 1469-221X; 1469-3178 — doi:10.1038/SJ.EMBOR.7400189 — PMID:15218527
  7. ↑ 7,00 7,01 7,02 7,03 7,04 7,05 7,06 7,07 7,08 7,09 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  8. ↑ 8,0 8,1 Bert J C Janssen, Mitchell K. J., Jones Y. et al. Structural basis of semaphorin-plexin signalling // Nature / M. Skipper — NPG, Springer Science+Business Media, 2010. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE09468 — PMID:20877282
  9. ↑ Vaisitti T., Tamagnone L., Malavasi F. CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival // Blood — American Society of Hematology, Elsevier, 2004. — ISSN 0006-4971; 1528-0020 — doi:10.1182/BLOOD-2004-10-3873 — PMID:15613544
  10. ↑ 10,0 10,1 10,2 Gilestro G. F., Comoglio P. M., Tamagnone L. et al. Plexin-B3 is a functional receptor for semaphorin 5A. // EMBO Rep. — NPG, 2004. — ISSN 1469-221X; 1469-3178 — doi:10.1038/SJ.EMBOR.7400189 — PMID:15218527
  11. ↑ Schultze J., Bensussan A., Freeman G. J. et al. Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 1996. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.93.21.11780 — PMID:8876214
  12. ↑ 12,0 12,1 12,2 12,3 12,4 Schultze J., Bensussan A., Freeman G. J. et al. Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 1996. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.93.21.11780 — PMID:8876214
  13. ↑ 13,0 13,1 13,2 13,3 13,4 Tamagnone L., Offermanns S. The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neurons via diverse pathways // Eur. J. Neurosci. — Wiley-Blackwell, Wiley, 2009. — ISSN 0953-816X; 1460-9568 — doi:10.1111/J.1460-9568.2009.06934.X — PMID:19788569
  14. ↑ 14,0 14,1 14,2 Basile J. R., Afkhami T., Gutkind J. S. Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway // Mol. Cell. Biol. — ASM, 2005. — ISSN 0270-7306; 1098-5549; 1067-8824 — doi:10.1128/MCB.25.16.6889-6898.2005 — PMID:16055703
  15. ↑ Tamagnone L., Offermanns S. The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neurons via diverse pathways // Eur. J. Neurosci. — Wiley-Blackwell, Wiley, 2009. — ISSN 0953-816X; 1460-9568 — doi:10.1111/J.1460-9568.2009.06934.X — PMID:19788569
  16. ↑ 16,0 16,1 16,2 16,3 16,4 16,5 Shinohara M., Friedel R. H. Suppression of bone formation by osteoclastic expression of semaphorin 4D // Nat. Med. — NPG, Springer Science+Business Media, 2011. — ISSN 1078-8956; 1546-170X — doi:10.1038/NM.2489 — PMID:22019888
  17. ↑ Basile J. R., Afkhami T., Gutkind J. S. Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway // Mol. Cell. Biol. — ASM, 2005. — ISSN 0270-7306; 1098-5549; 1067-8824 — doi:10.1128/MCB.25.16.6889-6898.2005 — PMID:16055703
  18. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  19. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)


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