PLAUR

PLAUR
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген Рецептор урокиназы[d][1]
Молекуляр функция protein domain specific binding[d][2], связывание с белками плазмы[d][3][4][5][…], urokinase plasminogen activator receptor activity[d][6][7][8][…], enzyme binding[d][9][10], signaling receptor binding[d][2], urokinase plasminogen activator receptor activity[d][11][12][13] һәм signaling receptor activity[d][14][11][12]
Күзәнәк компоненты мембрана өлеше[d][11], cell projection[d][13], endoplasmic reticulum lumen[d][13], endoplasmic reticulum membrane[d][13], мембрана[d][13], фокальные контакты[d][15], күзәнәк мембранасы өлеше[d][13], күзәнәк тышындагы өлкә[d][13], межклеточные контакты[d][13], anchored component of membrane[d][13], экзосома[d][16], extrinsic component of membrane[d][17], күзәнәк мембранасы[d][8][18][8][…], specific granule membrane[d][13], күзәнәк өслеге[d][10], күзәнәк мембранасы[d][13][14][13][…] һәм фокальные контакты[d][19]
Биологик процесс positive regulation of protein phosphorylation[d][20], negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway[d][20], фибринолиз[d][13], negative regulation of intrinsic apoptotic signaling pathway[d][20], urokinase plasminogen activator signaling pathway[d][8][8], негативная регуляция апоптоза[d][20], cвёртывание крови[d][17][12], attachment of GPI anchor to protein[d][8], хемотаксис[d][14], positive regulation of release of cytochrome c from mitochondria[d][20], positive regulation of DNA binding[d][20], positive regulation of epidermal growth factor receptor signaling pathway[d][20], regulation of proteolysis[d][11][13], передача сигнала[d][14], neutrophil degranulation[d][13] һәм urokinase plasminogen activator signaling pathway[d][13]
Изображение Gene Atlas

PLAUR (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[21][22]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,0 2,1 Kreiling J. L., Byrd J. C., Deisz R. J. et al. Binding of urokinase-type plasminogen activator receptor (uPAR) to the mannose 6-phosphate/insulin-like growth factor II receptor: contrasting interactions of full-length and soluble forms of uPAR // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2003. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M302249200 — PMID:12665524
  3. ↑ F Mahdi, Z Shariat-Madar, Todd R. F. et al. Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells // Blood — American Society of Hematology, Elsevier, 2001. — ISSN 0006-4971; 1528-0020 — doi:10.1182/BLOOD.V97.8.2342 — PMID:11290596
  4. ↑ Zhu Y., Bujo H., Yamazaki H. et al. LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration // Circ. Res. — Lippincott Williams & Wilkins, 2004. — ISSN 0009-7330; 1524-4571 — doi:10.1161/01.RES.0000120862.79154.0F — PMID:14764453
  5. ↑ Robaglia-Schlupp A., Szepetowski P., Massacrier A. et al. Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR // Human Molecular Genetics — OUP, 2008. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/DDN256 — PMID:18718938
  6. ↑ Roldan A. L., Cubellis M. V., Masucci M. T. et al. Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis // EMBO J. — NPG, 1990. — ISSN 0261-4189; 1460-2075 — doi:10.1002/(ISSN)1460-2075 — PMID:1689240
  7. ↑ C Pyke, J Eriksen, H Solberg et al. An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activator // FEBS Letters — Elsevier, 1993. — ISSN 0014-5793; 1873-3468 — doi:10.1016/0014-5793(93)81763-P — PMID:8392005
  8. ↑ 8,0 8,1 8,2 8,3 8,4 8,5 GOA
  9. ↑ Magdolen V. Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G // J. Immunol. — Baltimore: 2004. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.172.1.540 — PMID:14688365
  10. ↑ 10,0 10,1 Jin H., Song Y. P., Boel G. et al. Group A streptococcal surface GAPDH, SDH, recognizes uPAR/CD87 as its receptor on the human pharyngeal cell and mediates bacterial adherence to host cells // Journal of Molecular Biology / P. Wright — Elsevier, 2005. — ISSN 0022-2836; 1089-8638 — doi:10.1016/J.JMB.2005.04.063 — PMID:15922359
  11. ↑ 11,0 11,1 11,2 11,3 Roldan A. L., Cubellis M. V., Masucci M. T. et al. Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis // EMBO J. — NPG, 1990. — ISSN 0261-4189; 1460-2075 — doi:10.1002/(ISSN)1460-2075 — PMID:1689240
  12. ↑ 12,0 12,1 12,2 C Pyke, J Eriksen, H Solberg et al. An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activator // FEBS Letters — Elsevier, 1993. — ISSN 0014-5793; 1873-3468 — doi:10.1016/0014-5793(93)81763-P — PMID:8392005
  13. ↑ 13,00 13,01 13,02 13,03 13,04 13,05 13,06 13,07 13,08 13,09 13,10 13,11 13,12 13,13 13,14 13,15 GOA
  14. ↑ 14,0 14,1 14,2 14,3 A Shevelev, V Tkachuk The chemotactic action of urokinase on smooth muscle cells is dependent on its kringle domain. Characterization of interactions and contribution to chemotaxis // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2000. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M909080199 — PMID:10749881
  15. ↑ Waterman C., Yates J. R. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation // Nat. Cell Biol. — NPG, 2011. — ISSN 1465-7392; 1476-4679 — doi:10.1038/NCB2216 — PMID:21423176
  16. ↑ Farina A., Lane L., Lescuyer P. et al. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine // Journal of Proteomics — Elsevier, 2013. — ISSN 1874-3919; 0165-022X — doi:10.1016/J.JPROT.2013.01.012 — PMID:23376485
  17. ↑ 17,0 17,1 JR C., JG P., Kottra J et al. The structure of the urokinase-type plasminogen activator receptor gene // Blood — American Society of Hematology, Elsevier, 1994. — 6 p. — ISSN 0006-4971; 1528-0020 — PMID:8049431
  18. ↑ A Shevelev, V Tkachuk The chemotactic action of urokinase on smooth muscle cells is dependent on its kringle domain. Characterization of interactions and contribution to chemotaxis // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2000. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M909080199 — PMID:10749881
  19. ↑ Waterman C., Yates J. R. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation // Nat. Cell Biol. — NPG, 2011. — ISSN 1465-7392; 1476-4679 — doi:10.1038/NCB2216 — PMID:21423176
  20. ↑ 20,0 20,1 20,2 20,3 20,4 20,5 20,6 Gondi C. S., Rao J. S., Kotipatruni R. R. Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma, Apoptosis Induced by Knockdown of uPAR and MMP-9 is Mediated by Inactivation of EGFR/STAT3 Signaling in Medulloblastoma // PLOS ONE / PLOS ONE Editors — PLoS, 2012. — ISSN 1932-6203 — doi:10.1371/JOURNAL.PONE.0044798 — PMID:22984561
  21. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  22. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.