MBL2

MBL2
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген Лектин, связывающий маннозу[d][1]
Молекуляр функция calcium ion binding[d][2], calcium-dependent protein binding[d][3][4], связывание с белками плазмы[d][5][6][7], mannose binding[d][8][9][10][…], signaling receptor binding[d][11], связывание углеводов[d][12], serine-type endopeptidase activity[d][10] һәм mannose binding[d][13][11][12][…]
Күзәнәк компоненты коллаген[d][12], күзәнәк тышындагы өлкә[d][12][12], күзәнәк өслеге[d][13], күзәнәк тышындагы мохит[d][14][10][15], күзәнәк тышындагы мохит[d][16][12][17][…], внеклеточный матрикс[d][2] һәм collagen-containing extracellular matrix[d][2]
Биологик процесс Лектиновый путь активации системы комплемента[d][10][9][10][…], positive regulation of phagocytosis[d][12], killing by host of symbiont cells[d][12], negative regulation of viral process[d][17], процесс иммунной системы[d][12], complement activation[d][12], response to oxidative stress[d][11], acute-phase response[d][13], defense response to bacterium[d][13], Классический путь активации системы комплемента[d][12], Опсонизация[d][13], defense response to Gram-positive bacterium[d][12][18], врождённый иммунитет[d][12][17], протеолиз[d][10], Лектиновый путь активации системы комплемента[d][12][11][12][…] һәм growth plate cartilage chondrocyte morphogenesis[d][2]
Изображение Gene Atlas

MBL2 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[19][20]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,0 2,1 2,2 2,3 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  3. ↑ Thielens N. Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2 // J. Immunol. — Baltimore: 2002. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.169.10.5735 — PMID:12421953
  4. ↑ Gaboriaud C. Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2008. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M803551200 — PMID:18596036
  5. ↑ T Vorup-Jensen, S Thiel, T Christensen MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway // Immunity — Cell Press, Elsevier, 2001. — ISSN 1074-7613; 1097-4180 — doi:10.1016/S1074-7613(01)00161-3 — PMID:11485744
  6. ↑ Pedersen J. S., Andersen G. R., Le T M Le et al. Structural insights into the initiating complex of the lectin pathway of complement activation // Structure / C. D. Lima — Cell Press, Elsevier, 2015. — ISSN 0969-2126; 1878-4186 — doi:10.1016/J.STR.2014.10.024 — PMID:25579818
  7. ↑ Holmskov U., Houen G., Duus K. et al. CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site // FEBS J. — Wiley-Blackwell, 2010. — ISSN 1742-464X; 1742-4658 — doi:10.1111/J.1742-4658.2010.07901.X — PMID:21054788
  8. ↑ Wright S. D., Tobias P. S., Ulevitch R. J. et al. Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages // J. Exp. Med. — Rockefeller University Press, 1989. — ISSN 0022-1007; 1540-9538 — doi:10.1084/JEM.170.4.1231 — PMID:2477488
  9. ↑ 9,0 9,1 Collard C. D., Montalto M. C., Reenstra W. R. et al. Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1 // Am. J. Pathol. — Elsevier, 2001. — ISSN 0002-9440; 1525-2191 — doi:10.1016/S0002-9440(10)61779-8 — PMID:11549596
  10. ↑ 10,0 10,1 10,2 10,3 10,4 10,5 GOA
  11. ↑ 11,0 11,1 11,2 11,3 Collard C. D., Montalto M. C., Reenstra W. R. et al. Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1 // Am. J. Pathol. — Elsevier, 2001. — ISSN 0002-9440; 1525-2191 — doi:10.1016/S0002-9440(10)61779-8 — PMID:11549596
  12. ↑ 12,00 12,01 12,02 12,03 12,04 12,05 12,06 12,07 12,08 12,09 12,10 12,11 12,12 12,13 12,14 GOA
  13. ↑ 13,0 13,1 13,2 13,3 13,4 Wright S. D., Tobias P. S., Ulevitch R. J. et al. Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages // J. Exp. Med. — Rockefeller University Press, 1989. — ISSN 0022-1007; 1540-9538 — doi:10.1084/JEM.170.4.1231 — PMID:2477488
  14. ↑ Levinsky R. J. High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene // Human Molecular Genetics — OUP, 1992. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/1.9.709 — PMID:1304173
  15. ↑ Mantovani A., Gilbertson B., Reading P. C. et al. Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses // PLOS ONE / PLOS ONE Editors — PLoS, 2013. — ISSN 1932-6203 — doi:10.1371/JOURNAL.PONE.0059623 — PMID:23544079
  16. ↑ Levinsky R. J. High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene // Human Molecular Genetics — OUP, 1992. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/1.9.709 — PMID:1304173
  17. ↑ 17,0 17,1 17,2 Mantovani A., Gilbertson B., Reading P. C. et al. Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses // PLOS ONE / PLOS ONE Editors — PLoS, 2013. — ISSN 1932-6203 — doi:10.1371/JOURNAL.PONE.0059623 — PMID:23544079
  18. ↑ Hamblin M. R., Thiel S. Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus // J. Exp. Med. — Rockefeller University Press, 2004. — ISSN 0022-1007; 1540-9538 — doi:10.1084/JEM.20032207 — PMID:15148336
  19. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  20. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)

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