ISCU

ISCU
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген ISCU[d][1]
Молекуляр функция iron ion binding[d][2][3], molecular adaptor activity[d][4][4], 4 iron, 4 sulfur cluster binding[d][5], iron-sulfur cluster binding[d][3], ferrous iron binding[d][5], связывание с белками плазмы[d][6][7][8][…], связывание с ионом металла[d][3], iron-sulfur transferase activity[d][9] һәм 2 iron, 2 sulfur cluster binding[d][5]
Күзәнәк компоненты цитоплазма[10][11][10], цитозоль[d][3][4], митохондриальный матрикс[d][3][5], митохондрия[3][3][2][…], төш[4][3] һәм цитоплазма[3][2][3][…]
Биологик процесс protein maturation by iron-sulfur cluster transfer[d][10], small molecule metabolic process[d][3], iron-sulfur cluster assembly[d][2][3], cellular iron ion homeostasis[d][5], positive regulation of mitochondrial electron transport, NADH to ubiquinone[d][12], positive regulation of aconitate hydratase activity[d][12] һәм negative regulation of iron ion import across plasma membrane[d][12]

ISCU (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[13][14]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,0 2,1 2,2 2,3 Tong W. H., T Rouault Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells // EMBO J. — NPG, 2000. — ISSN 0261-4189; 1460-2075 — doi:10.1093/EMBOJ/19.21.5692 — PMID:11060020
  3. ↑ 3,00 3,01 3,02 3,03 3,04 3,05 3,06 3,07 3,08 3,09 3,10 3,11 GOA
  4. ↑ 4,0 4,1 4,2 4,3 Li K., Tong W., Hughes R. M. et al. Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2006. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M600582200 — PMID:16527810
  5. ↑ 5,0 5,1 5,2 5,3 5,4 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  6. ↑ Shan Y., Cortopassi G. Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly // Mitochondrion — Elsevier, 2015. — ISSN 1567-7249; 1872-8278 — doi:10.1016/J.MITO.2015.12.005 — PMID:26702583
  7. ↑ Rouault T. A. Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis, Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron–sulfur cluster biogenesis // Human Molecular Genetics — OUP, 2010. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/DDQ301 — PMID:20668094
  8. ↑ Dricot A., Barabási A., Tavernier J. et al. A proteome-scale map of the human interactome network // Cell — Cell Press, Elsevier, 2014. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2014.10.050 — PMID:25416956
  9. ↑ Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  10. ↑ 10,0 10,1 10,2 GOA
  11. ↑ Tong W. H., T Rouault Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells // EMBO J. — NPG, 2000. — ISSN 0261-4189; 1460-2075 — doi:10.1093/EMBOJ/19.21.5692 — PMID:11060020
  12. ↑ 12,0 12,1 12,2 Ragoussis J., Vojnovic B., Ramachandran A. et al. MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU // PLOS ONE / PLOS ONE Editors — PLoS, 2010. — ISSN 1932-6203 — doi:10.1371/JOURNAL.PONE.0010345 — PMID:20436681
  13. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  14. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)

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