FPGS

FPGS
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген FPGS[d][1]
Молекуляр функция нуклеотид-связывающий[d][2], активность лигазы[d][2][2], АТФ-связанные[d][2][2], tetrahydrofolylpolyglutamate synthase activity[d][3][4][3][…], связывание с ионом металла[d][2], dihydrofolate synthase activity[d][3] һәм tetrahydrofolylpolyglutamate synthase activity[d][2][5][2][…]
Күзәнәк компоненты цитозоль[d][3][4][6], мембрана[d][2], mitochondrial inner membrane[d][2], цитоплазма[7][3], митохондрия[4][3][6], митохондриальный матрикс[d][2][2], цитоплазма[8][2][9], митохондрия[5][2], митохондриальный матрикс[d][2][2][9], цитозоль[d][2][5], митохондрия[5][2][9] һәм цитозоль[d][2][5][9]
Биологик процесс one-carbon metabolic process[d][2], Биосинтез[d][2], развитие мозга[d][2], folic acid metabolic process[d][2], регенерация органов[d][2], развитие печени[d][2], glutamate metabolic process[d][10], пролиферация клеток[d][6], nucleobase-containing compound metabolic process[d][5], folic acid-containing compound biosynthetic process[d][2], folic acid-containing compound metabolic process[d][10], tetrahydrofolylpolyglutamate biosynthetic process[d][2][10], dihydrofolate biosynthetic process[d][3], folic acid-containing compound biosynthetic process[d][2][9] һәм tetrahydrofolylpolyglutamate biosynthetic process[d][2][10][9]

FPGS (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[11][12]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 2,19 2,20 2,21 2,22 2,23 2,24 2,25 2,26 2,27 2,28 GOA
  3. ↑ 3,0 3,1 3,2 3,3 3,4 3,5 3,6 GOA
  4. ↑ 4,0 4,1 4,2 Freemantle S. J., Taylor S. M., G Krystal et al. Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1995. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.270.16.9579 — PMID:7721888
  5. ↑ 5,0 5,1 5,2 5,3 5,4 5,5 Freemantle S. J., Taylor S. M., G Krystal et al. Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1995. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.270.16.9579 — PMID:7721888
  6. ↑ 6,0 6,1 6,2 Ferguson J., Lawrence S. A., Titus S. A. et al. Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2014. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M114.593244 — PMID:25164808
  7. ↑ A. Admon Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 1992. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.89.19.9151 — PMID:1409616
  8. ↑ A. Admon Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 1992. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.89.19.9151 — PMID:1409616
  9. ↑ 9,0 9,1 9,2 9,3 9,4 9,5 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  10. ↑ 10,0 10,1 10,2 10,3 Clarke L. Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists // Arch. Biochem. Biophys. — Academic Press, Elsevier, 1987. — ISSN 0003-9861; 1096-0384 — doi:10.1016/0003-9861(87)90616-3 — PMID:3619447
  11. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  12. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)

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