FLG

FLG
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген Филаггрин[d][1]
Молекуляр функция calcium ion binding[d][2], связывание с белками плазмы[d][3], structural molecule activity[d][4][2], связывание с ионом металла[d][2], transition metal ion binding[d][2], structural constituent of skin epidermis[d][5] һәм structural constituent of skin epidermis[d][6][7]
Күзәнәк компоненты промежуточные филаменты[d][4], keratohyalin granule[d][8][9], внутриклеточная мембранная органелла[d][2], төш[10], цитозоль[d][2], cornified envelope[d][5], cornified envelope[d][6][7], төш[11], keratohyalin granule[d][12][13][7] һәм collagen-containing extracellular matrix[d][14]
Биологик процесс развитие многоклеточного организма[d][4][2], keratinocyte differentiation[d][15], establishment of skin barrier[d][16], cornification[d][2], peptide cross-linking[d][6] һәм establishment of skin barrier[d][17][7]

FLG (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[18][19]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,0 2,1 2,2 2,3 2,4 2,5 2,6 2,7 GOA
  3. ↑ Tokura Y., Sakabe J., Kabashima K. Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes, Kallikrein-related Peptidase 5 Functions in Proteolytic Processing of Profilaggrin in Cultured Human Keratinocytes // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2013. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M113.476820 — PMID:23629652
  4. ↑ 4,0 4,1 4,2 Croce C. M. Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21 // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 1989. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.86.13.4848 — PMID:2740331
  5. ↑ 5,0 5,1 Steinert P. M., Marekov L. N. The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1995. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.270.30.17702 — PMID:7543090
  6. ↑ 6,0 6,1 6,2 Steinert P. M., Marekov L. N. The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1995. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.270.30.17702 — PMID:7543090
  7. ↑ 7,0 7,1 7,2 7,3 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  8. ↑ Presland R. B., Haydock P. V., P. Fleckman et al. Characterization of the human epidermal profilaggrin gene. Genomic organization and identification of an S-100-like calcium binding domain at the amino terminus // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1992. — ISSN 0021-9258; 1083-351X; 1067-8816 — PMID:1429717
  9. ↑ Presland R. B. Analysis of epidermal-type transglutaminase (transglutaminase 3) in human stratified epithelia and cultured keratinocytes using monoclonal antibodies // Journal of Dermatological Science — Elsevier, 2003. — ISSN 0923-1811; 1873-569X — doi:10.1016/S0923-1811(03)00091-4 — PMID:12850301
  10. ↑ Mateo S. d., Castillo J., Oliva R. Proteomic characterization of the human sperm nucleus // Proteomics / L. Stimson — Wiley, 2011. — ISSN 1615-9853; 1615-9861 — doi:10.1002/PMIC.201000799 — PMID:21630459
  11. ↑ Mateo S. d., Castillo J., Oliva R. Proteomic characterization of the human sperm nucleus // Proteomics / L. Stimson — Wiley, 2011. — ISSN 1615-9853; 1615-9861 — doi:10.1002/PMIC.201000799 — PMID:21630459
  12. ↑ Presland R. B., Haydock P. V., P. Fleckman et al. Characterization of the human epidermal profilaggrin gene. Genomic organization and identification of an S-100-like calcium binding domain at the amino terminus // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1992. — ISSN 0021-9258; 1083-351X; 1067-8816 — PMID:1429717
  13. ↑ Presland R. B. Analysis of epidermal-type transglutaminase (transglutaminase 3) in human stratified epithelia and cultured keratinocytes using monoclonal antibodies // Journal of Dermatological Science — Elsevier, 2003. — ISSN 0923-1811; 1873-569X — doi:10.1016/S0923-1811(03)00091-4 — PMID:12850301
  14. ↑ Reagan M. R., Naba A., Clauser K. R. et al. Proteomic characterization of human multiple myeloma bone marrow extracellular matrix // Leukemia — NPG, 2017. — ISSN 0887-6924; 1476-5551 — doi:10.1038/LEU.2017.102 — PMID:28344315
  15. ↑ Zigrino P., Nischt R. Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2007. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M701658200 — PMID:17704059
  16. ↑ Serre G., Méchin M., Balica S. et al. Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin // Journal of allergy and clinical immunology — Elsevier, 2013. — ISSN 1097-6825; 0091-6749; 1085-8725 — doi:10.1016/J.JACI.2012.12.1566 — PMID:23403047
  17. ↑ Serre G., Méchin M., Balica S. et al. Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin // Journal of allergy and clinical immunology — Elsevier, 2013. — ISSN 1097-6825; 0091-6749; 1085-8725 — doi:10.1016/J.JACI.2012.12.1566 — PMID:23403047
  18. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  19. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)

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