DGAT1

DGAT1
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген DGAT1[d][1]
Молекуляр функция трансферазная активность[d][2], O-acyltransferase activity[d][2], связывание с белками плазмы[d][3], 2-acylglycerol O-acyltransferase activity[d][2], retinol O-fatty-acyltransferase activity[d][2], acyltransferase activity[d][4][2], diacylglycerol O-acyltransferase activity[d][5][6][5][…], diacylglycerol O-acyltransferase activity[d][5][6][5][…] һәм diacylglycerol O-acyltransferase activity[d][7][2][2][…]
Күзәнәк компоненты мембрана өлеше[d][2][2][2], endoplasmic reticulum membrane[d][2][2][8], мембрана[d][2][2], внутриклеточная мембранная органелла[d][2], эндоплазматик челтәр[2], күзәнәк мембранасы[d][2] һәм specific granule membrane[d][2]
Биологик процесс glycerolipid metabolic process[d][2], retinol metabolic process[d][2], lipid storage[d][2][2], fatty acid homeostasis[d][2], diacylglycerol metabolic process[d][2][2], triglyceride biosynthetic process[d][5][5][5][…], very-low-density lipoprotein particle assembly[d][9], long-chain fatty-acyl-CoA metabolic process[d][2][2], triglyceride metabolic process[d][4], acylglycerol acyl-chain remodeling[d][2], neutrophil degranulation[d][2] һәм triglyceride biosynthetic process[d][2][2][2][…]
Тәэсир итешә pradigastat[d][10]
Шифр КФ 2.3.1.76[11]

DGAT1 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[12][13]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 2,19 2,20 2,21 2,22 2,23 2,24 2,25 2,26 2,27 2,28 2,29 2,30 2,31 GOA
  3. ↑ Herker E., Ramage H., Ott M. Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2013. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M112.434910 — PMID:23420847
  4. ↑ 4,0 4,1 P. Oelkers, A. Behari, D. Cromley et al. Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes, Characterization of Two Human Genes Encoding Acyl Coenzyme A:Cholesterol Acyltransferase-related Enzymes // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1998. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.273.41.26765 — PMID:9756920
  5. ↑ 5,0 5,1 5,2 5,3 5,4 5,5 5,6 GOA
  6. ↑ 6,0 6,1 S. Cases, Smith S. J., Zheng Y. W. et al. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 1998. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.95.22.13018 — PMID:9789033
  7. ↑ S. Cases, Smith S. J., Zheng Y. W. et al. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 1998. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.95.22.13018 — PMID:9789033
  8. ↑ Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  9. ↑ Oelkers P. Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2004. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M408507200 — PMID:15308631
  10. ↑ Open Targets Platform
  11. ↑ Swiss Prot — 1986.
  12. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  13. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)

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