CUBN

CUBN
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген CUBN[d][1]
Молекуляр функция calcium ion binding[d][2], гомодимеризация белка[d][3], связывание с белками плазмы[d][4], transporter activity[d][5], cobalamin binding[d][2], связывание с ионом металла[d][2], channel regulator activity[d][6], hemoglobin binding[d][6], signaling receptor activity[d][7][6], cargo receptor activity[d][6], гомодимеризация белка[d][3][6], signaling receptor activity[d][7] һәм cargo receptor activity[d][5]
Күзәнәк компоненты brush border[d][2], extrinsic component of external side of plasma membrane[d][8], эндоплазматик челтәр[2], clathrin-coated pit[d][2][2], lysosomal membrane[d][2], цитоплазма[2], Гольджи аппараты[2], эндосома[d][2][2], apical part of cell[d][2], лизосома[2], lysosomal lumen[d][2], мембрана[d][5][2], цитозоль[d][2], экзосома[d][9][10][11][…], endocytic vesicle[d][2][4], endosome membrane[d][2], күзәнәк мембранасы[d][2][2], apical plasma membrane[d][2][2][2][…], brush border membrane[d][8][2], Golgi-associated vesicle[d][6], clathrin-coated pit[d][2][2][6], ionotropic glutamate receptor complex[d][6], apical plasma membrane[d][2][2][2][…], coated vesicle[d][6], endocytic vesicle[d][2][4][6], endocytic vesicle membrane[d][6], brush border membrane[d][8][2][6], neuron projection membrane[d][6], lysosomal lumen[d][2][6], синапс[6], экзосома[d][12][6][13][…], күзәнәк мембранасы[d][2][2][6] һәм экзосома[d][12][13][14]
Биологик процесс тканевый гомеостаз[d][8], cobalamin transport[d][7], липидный обмен[d][2], транспорт белков[d][2], cholesterol metabolic process[d][2], vitamin D metabolic process[d][2], cobalamin metabolic process[d][2], steroid metabolic process[d][2], эндоцитоз[d][2], lipoprotein transport[d][2], рецепторно-опосредованный эндоцитоз[d][8][2], high-density lipoprotein particle clearance[d][2], перенос[d][15], in utero embryonic development[d][6], thigmotaxis[d][6], hyperosmotic response[d][6], response to nutrient[d][6], adult locomotory behavior[d][6], response to bacterium[d][2], cobalamin transport[d][7][6], endocytic hemoglobin import into cell[d][6], регулирование передвижения[d][6], cobalamin catabolic process[d][6], positive regulation of synaptic transmission, glutamatergic[d][6] һәм protein homotrimerization[d][6]
Изображение Gene Atlas

CUBN (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[16][17]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 2,19 2,20 2,21 2,22 2,23 2,24 2,25 2,26 2,27 2,28 2,29 2,30 2,31 2,32 2,33 2,34 2,35 2,36 2,37 2,38 2,39 2,40 2,41 2,42 2,43 2,44 2,45 GOA
  3. ↑ 3,0 3,1 Xu D, Kozyraki R, TC N. et al. Genetic evidence of an accessory activity required specifically for cubilin brush-border expression and intrinsic factor-cobalamin absorption // Blood — American Society of Hematology, Elsevier, 1999. — ISSN 0006-4971; 1528-0020 — PMID:10552972
  4. ↑ 4,0 4,1 4,2 Chapelle A. d. l., Højrup P., Moestrup S. K. et al. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless // Blood — American Society of Hematology, Elsevier, 2004. — ISSN 0006-4971; 1528-0020 — doi:10.1182/BLOOD-2003-08-2852 — PMID:14576052
  5. ↑ 5,0 5,1 5,2 R Kozyraki The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1998. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.273.9.5235 — PMID:9478979
  6. ↑ 6,00 6,01 6,02 6,03 6,04 6,05 6,06 6,07 6,08 6,09 6,10 6,11 6,12 6,13 6,14 6,15 6,16 6,17 6,18 6,19 6,20 6,21 6,22 6,23 6,24 6,25 6,26 6,27 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  7. ↑ 7,0 7,1 7,2 7,3 Jenner L., Chapelle A. d. l. Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1 // Nature Genetics / M. Axton, T. Faial — NPG, 1999. — ISSN 1061-4036; 1546-1718 — doi:10.1038/6831 — PMID:10080186
  8. ↑ 8,0 8,1 8,2 8,3 8,4 Christensen E. I., Birn H. Megalin and cubilin: multifunctional endocytic receptors // Nat. Rev. Mol. Cell Biol. — NPG, 2002. — ISSN 1471-0072; 1471-0080 — doi:10.1038/NRM778 — PMID:11994745
  9. ↑ Farina A., Lane L., Lescuyer P. et al. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine // Journal of Proteomics — Elsevier, 2013. — ISSN 1874-3919; 0165-022X — doi:10.1016/J.JPROT.2013.01.012 — PMID:23376485
  10. ↑ Pisitkun T., Tchapyjnikov D., Knepper M. A. Large-scale proteomics and phosphoproteomics of urinary exosomes // Journal of the American Society of Nephrology / J. Briggs — American Society of Nephrology, 2008. — ISSN 1046-6673; 1533-3450 — doi:10.1681/ASN.2008040406 — PMID:19056867
  11. ↑ Sinha A., Kislinger T. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine // Proteomics / L. Stimson — Wiley, 2013. — ISSN 1615-9853; 1615-9861 — doi:10.1002/PMIC.201200561 — PMID:23533145
  12. ↑ 12,0 12,1 Zhang Y., Li Y., Qiu F. et al. Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS // Electrophoresis — Wiley-VCH, 2010. — ISSN 0173-0835; 1522-2683 — doi:10.1002/ELPS.201000401 — PMID:21082674
  13. ↑ 13,0 13,1 Pisitkun T., Tchapyjnikov D., Knepper M. A. Large-scale proteomics and phosphoproteomics of urinary exosomes // Journal of the American Society of Nephrology / J. Briggs — American Society of Nephrology, 2008. — ISSN 1046-6673; 1533-3450 — doi:10.1681/ASN.2008040406 — PMID:19056867
  14. ↑ Sinha A., Kislinger T. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine // Proteomics / L. Stimson — Wiley, 2013. — ISSN 1615-9853; 1615-9861 — doi:10.1002/PMIC.201200561 — PMID:23533145
  15. ↑ GOA
  16. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  17. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)

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