CRBN

CRBN
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген CRBN[d][1]
Молекуляр функция связывание с белками плазмы[d][2][3][4][…] һәм связывание с ионом металла[d][5]
Күзәнәк компоненты цитоплазма[5][5][2], Cul4A-RING E3 ubiquitin ligase complex[d][6], ядрышко[d][5], мембрана[d][5], төш[5][2] һәм Cul4A-RING E3 ubiquitin ligase complex[d][2][7]
Биологик процесс negative regulation of protein homooligomerization[d][5], positive regulation of protein homodimerization activity[d][5], protein ubiquitination[d][6][8], proteasome-mediated ubiquitin-dependent protein catabolic process[d][2], negative regulation of ion transmembrane transport[d][5] һәм protein ubiquitination[d][2][5][7]
Тәэсир итешә талидомид[d][9]

CRBN (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[10][11]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,0 2,1 2,2 2,3 2,4 2,5 Ito T. Identification of a primary target of thalidomide teratogenicity, Identification of a Primary Target of Thalidomide Teratogenicity // Science / H. Thorp — Northern America: AAAS, 2010. — ISSN 0036-8075; 1095-9203 — doi:10.1126/SCIENCE.1177319 — PMID:20223979
  3. ↑ Dricot A., Barabási A., Tavernier J. et al. A proteome-scale map of the human interactome network // Cell — Cell Press, Elsevier, 2014. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2014.10.050 — PMID:25416956
  4. ↑ Petzold G., Fischer E. S. Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase // Nature / M. Skipper — NPG, Springer Science+Business Media, 2016. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE16979 — PMID:26909574
  5. ↑ 5,00 5,01 5,02 5,03 5,04 5,05 5,06 5,07 5,08 5,09 GOA
  6. ↑ 6,0 6,1 Ito T. Identification of a primary target of thalidomide teratogenicity, Identification of a Primary Target of Thalidomide Teratogenicity // Science / H. Thorp — Northern America: AAAS, 2010. — ISSN 0036-8075; 1095-9203 — doi:10.1126/SCIENCE.1177319 — PMID:20223979
  7. ↑ 7,0 7,1 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  8. ↑ GOA
  9. ↑ Open Targets Platform
  10. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  11. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)

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