CD81

CD81
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген CD81[d][1]
Молекуляр функция связывание с белками плазмы[d][2][3][4][…], MHC class II protein complex binding[d][5], transferrin receptor binding[d][6], virus receptor activity[d][2][7], integrin binding[d][8], cholesterol binding[d][9], MHC class II protein complex binding[d][5] һәм lipid binding[d][7]
Күзәнәк компоненты мембрана өлеше[d][7][7], везикула[d][10], мембрана[d][7][7][11], фокальные контакты[d][12], күзәнәк мембранасы өлеше[d][13], иммунологик синапс[d][14], экзосома[d][15][16][17][…], күзәнәк мембранасы[d][7][7], basolateral plasma membrane[d][7][2], күзәнәк мембранасы өлеше[d][18][13][19], фокальные контакты[d][12], мембрана[d][7][7][11], мембрана өлеше[d][7][7][9] һәм экзосома[d][15][20][21][…]
Биологик процесс positive regulation of 1-phosphatidylinositol 4-kinase activity[d][13], локализация белка[d][13], regulation of protein stability[d][6], receptor internalization[d][7][7], cellular response to low-density lipoprotein particle stimulus[d][7][7], регулирование движения клеток[d][7], receptor-mediated virion attachment to host cell[d][13], protein localization to lysosome[d][6], cell surface receptor signaling pathway[d][19], positive regulation of B cell proliferation[d][22], позитивная регуляция пролиферации клеток[d][13], regulation of immune response[d][7], positive regulation of peptidyl-tyrosine phosphorylation[d][13], viral entry into host cell[d][13], positive regulation of protein catabolic process in the vacuole[d][6], пролиферация клеток[d][23], вирусный процесс[d][7], положительная регуляция транскрипции РНК полимеразой II промотор[d][6], regulation of complement activation[d][7], humoral immune response mediated by circulating immunoglobulin[d][18], protein localization to plasma membrane[d][18][9], adaptive immune response[d][7] һәм процесс иммунной системы[d][7]
 CD81 Викиҗыентыкта

CD81 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[24][25]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,0 2,1 2,2 McKeating J. A., Mullins J., Mee C. J. et al. Claudin association with CD81 defines hepatitis C virus entry // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2010. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M110.104836 — PMID:20375010
  3. ↑ Kwong P. D. Dimeric association and segmental variability in the structure of human CD4 // Nature / M. Skipper — NPG, Springer Science+Business Media, 1997. — ISSN 1476-4687; 0028-0836 — doi:10.1038/387527A0 — PMID:9168119
  4. ↑ Stipp C. S., Kolesnikova T. V., Hemler M. E. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2001. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M107338200 — PMID:11504738
  5. ↑ 5,0 5,1 Buschow S. I., Stoorvogel W., Wauben M. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis // Immunology & Cell Biology — Wiley, 2010. — ISSN 0818-9641; 1440-1711 — doi:10.1038/ICB.2010.64 — PMID:20458337
  6. ↑ 6,0 6,1 6,2 6,3 6,4 Chen J., Enns C. A. CD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2015. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M114.632778 — PMID:25635054
  7. ↑ 7,00 7,01 7,02 7,03 7,04 7,05 7,06 7,07 7,08 7,09 7,10 7,11 7,12 7,13 7,14 7,15 7,16 7,17 7,18 7,19 7,20 7,21 7,22 GOA
  8. ↑ Yu J., Lee C., Changou C. A. et al. The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin αvβ3. // Biochem. J. — London [etc.]: Portland Press, 2016. — 8 p. — ISSN 0264-6021; 1470-8728 — doi:10.1042/BCJ20160998 — PMID:27993971
  9. ↑ 9,0 9,1 9,2 Kelly B., Dror R. O. Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket // Cell — Cell Press, Elsevier, 2016. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2016.09.056 — PMID:27881302
  10. ↑ I. Tachibana, J. Bodorova, F. Berditchevski et al. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins, NAG-2, a Novel Transmembrane-4 Superfamily (TM4SF) Protein That Complexes with Integrins and Other TM4SF Proteins // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1997. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.272.46.29181 — PMID:9360996
  11. ↑ 11,0 11,1 Lippert D. Defining the membrane proteome of NK cells // J. Mass Spectrom. — Wiley, 2010. — ISSN 1076-5174; 1096-9888 — doi:10.1002/JMS.1696 — PMID:19946888
  12. ↑ 12,0 12,1 Waterman C., Yates J. R. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation // Nat. Cell Biol. — NPG, 2011. — ISSN 1465-7392; 1476-4679 — doi:10.1038/NCB2216 — PMID:21423176
  13. ↑ 13,0 13,1 13,2 13,3 13,4 13,5 13,6 13,7 Ravichandran K. S., Mazzocca A. Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells // Oncogene — NPG, 2004. — ISSN 0950-9232; 1476-5594 — doi:10.1038/SJ.ONC.1207287 — PMID:14676841
  14. ↑ Stepanek O., Weiss A., Horejsi V. et al. SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling // Mol. Cell. Biol. — ASM, 2011. — ISSN 0270-7306; 1098-5549; 1067-8824 — doi:10.1128/MCB.05817-11 — PMID:21930792
  15. ↑ 15,0 15,1 Looze C., Yui D., Leung L. et al. Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein // Biochem. Biophys. Res. Commun. — Academic Press, Elsevier, 2009. — ISSN 0006-291X; 1090-2104 — doi:10.1016/J.BBRC.2008.11.050 — PMID:19028452
  16. ↑ Yates J. R. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT) // J. Proteome Res. / J. Yates — ACS, 2009. — ISSN 1535-3893; 1535-3907 — doi:10.1021/PR800658C — PMID:19199708
  17. ↑ Sinha A., Kislinger T. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine // Proteomics / L. Stimson — Wiley, 2013. — ISSN 1615-9853; 1615-9861 — doi:10.1002/PMIC.201200561 — PMID:23533145
  18. ↑ 18,0 18,1 18,2 Menno C van Zelm, Mirjam van der Burg, Jacques J M van Dongen CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency // J. Clin. Invest. / R. S. Ahima — American Society for Clinical Investigation, 2010. — ISSN 0021-9738; 1558-8238 — doi:10.1172/JCI39748 — PMID:20237408
  19. ↑ 19,0 19,1 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  20. ↑ Lötvall J., Eldh M., Ekström K. et al. Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages // J. Transl. Med. — BMC, Springer Science+Business Media, 2011. — ISSN 1479-5876 — doi:10.1186/1479-5876-9-9 — PMID:21235781
  21. ↑ Atay S. Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells // Exp. Cell. Res. — Academic Press, Elsevier, 2011. — ISSN 0014-4827; 1090-2422 — doi:10.1016/J.YEXCR.2011.01.014 — PMID:21276792
  22. ↑ M Flint, C Maidens, Loomis-Price L. D. et al. Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81 // J. Virol. — ASM, 1999. — ISSN 0022-538X; 1098-5514; 1070-6321 — PMID:10400713
  23. ↑ R. Oren, S. Takahashi, C. Doss et al. TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins // Mol. Cell. Biol. — ASM, 1990. — ISSN 0270-7306; 1098-5549; 1067-8824 — doi:10.1128/MCB.10.8.4007-4015.1990 — PMID:1695320
  24. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  25. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)

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