CD44

CD44
Молекулярная модель
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген CD44[d][1]
Молекуляр функция collagen binding[d][2], связывание с белками плазмы[d][3][4][5][…], hyaluronic acid binding[d][6][7][8][…], cytokine receptor activity[d][9], transmembrane signaling receptor activity[d][10], cytokine receptor activity[d][11][10] һәм hyaluronic acid binding[d][12][13][14][…]
Күзәнәк компоненты мембрана өлеше[d][13][13], Гольджи аппараты[13], macrophage migration inhibitory factor receptor complex[d][9], мембрана[d][13], фокальные контакты[d][15], күзәнәк мембранасы[d][7][7][16][…], күзәнәк мембранасы өлеше[d][12], күзәнәк өслеге[d][17][18], экзосома[d][19][20][21], цитозоль[d][13], secretory granule membrane[d][13], apical plasma membrane[d][3], lamellipodium membrane[d][3], cell projection[d][16], күзәнәк мембранасы[d][13][13][3][…], Микроворсинка[d][13][13], фокальные контакты[d][22], basolateral plasma membrane[d][10], macrophage migration inhibitory factor receptor complex[d][11][10], cell projection[d][13][3] һәм экзосома[d][23][24][25]
Биологик процесс negative regulation of cysteine-type endopeptidase activity involved in apoptotic process[d][26], monocyte aggregation[d][27], positive regulation of heterotypic cell-cell adhesion[d][27], hyaluronan catabolic process[d][13][17], negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator[d][11], interferon-gamma-mediated signaling pathway[d][13], extracellular matrix disassembly[d][13], extracellular matrix organization[d][13], негативная регуляция апоптоза[d][26], cellular response to fibroblast growth factor stimulus[d][28], positive regulation of peptidyl-serine phosphorylation[d][11], cartilage development[d][29], агрегация клеток[d][7][7], negative regulation of DNA damage response, signal transduction by p53 class mediator[d][11], positive regulation of ERK1 and ERK2 cascade[d][9], positive regulation of peptidyl-tyrosine phosphorylation[d][11], cell-matrix adhesion[d][30], positive regulation of monocyte aggregation[d][31], leukocyte migration[d][13], neutrophil degranulation[d][13], wound healing, spreading of cells[d][3], regulation of lamellipodium morphogenesis[d][3], cell-cell adhesion[d][30], воспалительная реакция[d][10], агрегация клеток[d][7][7][32], positive regulation of ERK1 and ERK2 cascade[d][11][10], агрегация клеток[d][13][13][33][…], миграция клеток[d][34] һәм T cell activation[d][35]
Изображение Gene Atlas
 CD44 Викиҗыентыкта

CD44 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[36][37]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ Gallatin W. M., Wayner E. A., Hoffman P. A. et al. Structural homology between lymphocyte receptors for high endothelium and class III extracellular matrix receptor // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 1989. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.86.12.4654 — PMID:2471973
  3. ↑ 3,0 3,1 3,2 3,3 3,4 3,5 3,6 Jones G. E., Pérez-Gómez E., Megías D. Podoplanin associates with CD44 to promote directional cell migration // Mol. Biol. Cell, — American Society for Cell Biology, 2010. — ISSN 1059-1524; 1939-4586; 1044-2030 — doi:10.1091/MBC.E10-06-0489 — PMID:20962267
  4. ↑ Ssadh H. A., Spencer P. S., Alabdulmenaim W. et al. Measurements of heterotypic associations between cluster of differentiation CD74 and CD44 in human breast cancer-derived cells // Oncotarget / M. Blagosklonny — Impact Journals LLC, 2017. — ISSN 1949-2553 — doi:10.18632/ONCOTARGET.20922 — PMID:29190904
  5. ↑ Hsu K., Tsai H., Lin P. et al. Clinical implication and mitotic effect of CD44 cleavage in relation to osteopontin/CD44 interaction and dysregulated cell cycle protein in gastrointestinal stromal tumor // Ann. Surg. Oncol. / K. M. McMasters — Springer Science+Business Media, 2010. — ISSN 1068-9265; 1534-4681 — doi:10.1245/S10434-010-0927-1 — PMID:20146103
  6. ↑ I Stamenkovic, A Aruffo, M Amiot et al. The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells // EMBO J. — NPG, 1991. — ISSN 0261-4189; 1460-2075 — doi:10.1002/(ISSN)1460-2075 — PMID:1991450
  7. ↑ 7,0 7,1 7,2 7,3 7,4 7,5 7,6 GOA
  8. ↑ Harada H., Takahashi M. CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2007. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M608358200 — PMID:17170110
  9. ↑ 9,0 9,1 9,2 Bucala R., Wang T. CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex // Immunity — Cell Press, Elsevier, 2006. — ISSN 1074-7613; 1097-4180 — doi:10.1016/J.IMMUNI.2006.08.020 — PMID:17045821
  10. ↑ 10,0 10,1 10,2 10,3 10,4 10,5 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  11. ↑ 11,0 11,1 11,2 11,3 11,4 11,5 11,6 Bucala R., Wang T. CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex // Immunity — Cell Press, Elsevier, 2006. — ISSN 1074-7613; 1097-4180 — doi:10.1016/J.IMMUNI.2006.08.020 — PMID:17045821
  12. ↑ 12,0 12,1 I Stamenkovic, A Aruffo, M Amiot et al. The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells // EMBO J. — NPG, 1991. — ISSN 0261-4189; 1460-2075 — doi:10.1002/(ISSN)1460-2075 — PMID:1991450
  13. ↑ 13,00 13,01 13,02 13,03 13,04 13,05 13,06 13,07 13,08 13,09 13,10 13,11 13,12 13,13 13,14 13,15 13,16 13,17 13,18 13,19 GOA
  14. ↑ Li L., Asteriou T., Bernert B. et al. Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB // Biochem. J. — London [etc.]: Portland Press, 2007. — ISSN 0264-6021; 1470-8728 — doi:10.1042/BJ20061757 — PMID:17324121
  15. ↑ Waterman C., Yates J. R. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation // Nat. Cell Biol. — NPG, 2011. — ISSN 1465-7392; 1476-4679 — doi:10.1038/NCB2216 — PMID:21423176
  16. ↑ 16,0 16,1 Jones G. E., Pérez-Gómez E., Megías D. Podoplanin associates with CD44 to promote directional cell migration // Mol. Biol. Cell, — American Society for Cell Biology, 2010. — ISSN 1059-1524; 1939-4586; 1044-2030 — doi:10.1091/MBC.E10-06-0489 — PMID:20962267
  17. ↑ 17,0 17,1 Harada H., Takahashi M. CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2007. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M608358200 — PMID:17170110
  18. ↑ Ottoboni L., Meregalli M., Torrente Y. et al. VCAM-1 expression on dystrophic muscle vessels has a critical role in the recruitment of human blood-derived CD133+ stem cells after intra-arterial transplantation // Blood — American Society of Hematology, Elsevier, 2006. — ISSN 0006-4971; 1528-0020 — doi:10.1182/BLOOD-2006-04-018564 — PMID:16809613
  19. ↑ Yates J. R. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT) // J. Proteome Res. / J. Yates — ACS, 2009. — ISSN 1535-3893; 1535-3907 — doi:10.1021/PR800658C — PMID:19199708
  20. ↑ Sinha A., Kislinger T. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine // Proteomics / L. Stimson — Wiley, 2013. — ISSN 1615-9853; 1615-9861 — doi:10.1002/PMIC.201200561 — PMID:23533145
  21. ↑ Buschow S. I., Stoorvogel W., Wauben M. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis // Immunology & Cell Biology — Wiley, 2010. — ISSN 0818-9641; 1440-1711 — doi:10.1038/ICB.2010.64 — PMID:20458337
  22. ↑ Waterman C., Yates J. R. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation // Nat. Cell Biol. — NPG, 2011. — ISSN 1465-7392; 1476-4679 — doi:10.1038/NCB2216 — PMID:21423176
  23. ↑ Yates J. R. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT) // J. Proteome Res. / J. Yates — ACS, 2009. — ISSN 1535-3893; 1535-3907 — doi:10.1021/PR800658C — PMID:19199708
  24. ↑ Buschow S. I., Stoorvogel W., Wauben M. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis // Immunology & Cell Biology — Wiley, 2010. — ISSN 0818-9641; 1440-1711 — doi:10.1038/ICB.2010.64 — PMID:20458337
  25. ↑ Sinha A., Kislinger T. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine // Proteomics / L. Stimson — Wiley, 2013. — ISSN 1615-9853; 1615-9861 — doi:10.1002/PMIC.201200561 — PMID:23533145
  26. ↑ 26,0 26,1 Lilly Y W Bourguignon, Xia W., Wong G. Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2009. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M806708200 — PMID:19047049
  27. ↑ 27,0 27,1 Selbi W., Motte C. d. l., Hascall V. et al. BMP-7 modulates hyaluronan-mediated proximal tubular cell-monocyte interaction // Journal of the American Society of Nephrology / J. Briggs — American Society of Nephrology, 2004. — ISSN 1046-6673; 1533-3450 — doi:10.1097/01.ASN.0000125619.27422.8E — PMID:15100360
  28. ↑ Tzanakakis G. N. bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells // Biochim. Biophys. Acta — Elsevier, 2009. — ISSN 0006-3002; 1878-2434 — doi:10.1016/J.BBAGEN.2009.06.013 — PMID:19577615
  29. ↑ Nicoll S. B., Barak O., Csóka A. B. et al. Hyaluronidases and CD44 undergo differential modulation during chondrogenesis // Biochem. Biophys. Res. Commun. — Academic Press, Elsevier, 2002. — ISSN 0006-291X; 1090-2104 — doi:10.1006/BBRC.2002.6697 — PMID:11944887
  30. ↑ 30,0 30,1 E Shtivelman, Bishop J. M. Expression of CD44 is repressed in neuroblastoma cells // Mol. Cell. Biol. — ASM, 1991. — ISSN 0270-7306; 1098-5549; 1067-8824 — doi:10.1128/MCB.11.11.5446 — PMID:1922057
  31. ↑ Vigetti D., Genasetti A., Karousou E. et al. Proinflammatory cytokines induce hyaluronan synthesis and monocyte adhesion in human endothelial cells through hyaluronan synthase 2 (HAS2) and the nuclear factor-kappaB (NF-kappaB) pathway // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2010. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M110.134536 — PMID:20522558
  32. ↑ Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  33. ↑ Lalor P., Newsome P., Adams D. Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4 // Journal of Hepatology — Elsevier, 2009. — 16 p. — ISSN 0168-8278; 1600-0641 — doi:10.1016/J.JHEP.2009.06.021 — PMID:19703720
  34. ↑ Yoshida T., Matsuda Y., Naito Z. et al. CD44 in human glioma correlates with histopathological grade and cell migration // Pathology International — Wiley-Blackwell, Wiley, 2012. — ISSN 1320-5463; 1440-1827 — doi:10.1111/J.1440-1827.2012.02823.X — PMID:22726066
  35. ↑ Funaro A., Malavasi F. Stimulation of T cells via CD44 requires leukocyte-function-associated antigen interactions and interleukin-2 production // Hum Immunol — Elsevier, 1994. — ISSN 0198-8859; 1879-1166 — doi:10.1016/0198-8859(94)90026-4 — PMID:7528188
  36. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  37. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)

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