CD40

CD40
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген CD40[d][1]
Молекуляр функция antigen binding[d][2], signal transducer activity[d][3], связывание с белками плазмы[d][4][5][6][…], tumor necrosis factor-activated receptor activity[d][7], enzyme binding[d][8], ubiquitin protein ligase binding[d][9], protein domain specific binding[d][2] һәм signaling receptor activity[d][10][2]
Күзәнәк компоненты цитоплазма[2], мембрана өлеше[d][2], внутриклеточная мембранная органелла[d][2], мембрана[d][2], күзәнәк мембранасы[d][2][11][2][…], күзәнәк мембранасы өлеше[d][11], күзәнәк тышындагы өлкә[d][2], күзәнәк өслеге[d][7][12], CD40 receptor complex[d][2][2], экзосома[d][13], наружная сторона клеточной мембраны[d][2][2], күзәнәк тышындагы мохит[d][2], soma[d][2], varicosity[d][2], күзәнәк өслеге[d][2][14] һәм экзосома[d][15]
Биологик процесс positive regulation of protein phosphorylation[d][16], positive regulation of MAP kinase activity[d][16], positive regulation of interleukin-12 production[d][2], protein kinase B signaling[d][2], positive regulation of protein kinase C signaling[d][16], процесс иммунной системы[d][2], cellular calcium ion homeostasis[d][16][2], tumor necrosis factor-mediated signaling pathway[d][2], immune response-regulating cell surface receptor signaling pathway[d][2], platelet activation[d][4], развитие многоклеточного организма[d][7], B cell activation[d][2][2], positive regulation of GTPase activity[d][16], response to lipopolysaccharide[d][7], B cell proliferation[d][17], cellular response to mechanical stimulus[d][18], positive regulation of endothelial cell apoptotic process[d][19], regulation of cell population proliferation[d][7], positive regulation of B cell proliferation[d][2], positive regulation of NF-kappaB transcription factor activity[d][16], defense response to virus[d][2], иммун җавап[d][7], regulation of immune response[d][2][2][2], positive regulation of I-kappaB kinase/NF-kappaB signaling[d][20], apoptotic signaling pathway[d][7], positive regulation of isotype switching to IgG isotypes[d][2], cellular response to lipopolysaccharide[d][2], положительная регуляция транскрипции РНК полимеразой II промотор[d][16], defense response to protozoan[d][2], response to bacterium[d][2], response to nutrient levels[d][2], response to cobalamin[d][2], response to interferon-gamma[d][2], cellular response to erythropoietin[d][2], cellular response to interleukin-1[d][2], cellular response to tumor necrosis factor[d][2], response to peptide[d][2], воспалительная реакция[d][21][7][7], positive regulation of tyrosine phosphorylation of STAT protein[d][16], positive regulation of blood vessel endothelial cell migration[d][22], positive regulation of angiogenesis[d][22], воспалительная реакция[d][23][2] һәм protein-containing complex assembly[d][11]

CD40 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[24][25]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 2,19 2,20 2,21 2,22 2,23 2,24 2,25 2,26 2,27 2,28 2,29 2,30 2,31 2,32 2,33 2,34 2,35 2,36 2,37 2,38 2,39 2,40 2,41 2,42 GOA
  3. ↑ F. Mach, U. Schönbeck, Sukhova G. K. et al. Reduction of atherosclerosis in mice by inhibition of CD40 signalling // Nature / M. Skipper — NPG, Springer Science+Business Media, 1998. — ISSN 1476-4687; 0028-0836 — doi:10.1038/28204 — PMID:9671306
  4. ↑ 4,0 4,1 Slupsky J. R., Forster R. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells // Nature / M. Skipper — NPG, Springer Science+Business Media, 1998. — ISSN 1476-4687; 0028-0836 — doi:10.1038/35393 — PMID:9468137
  5. ↑ Hu H. M., K O'Rourke, Boguski M. S. et al. A novel RING finger protein interacts with the cytoplasmic domain of CD40 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1994. — ISSN 0021-9258; 1083-351X; 1067-8816 — PMID:7527023
  6. ↑ Casanova J., Cunningham-Rundles C., Puel A. et al. The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88 // Nat. Immunol. — USA: NPG, 2010. — ISSN 1529-2908; 1529-2916 — doi:10.1038/NI.1914 — PMID:20676093
  7. ↑ 7,0 7,1 7,2 7,3 7,4 7,5 7,6 7,7 7,8 GOA
  8. ↑ Nemoto E., Tada H., Shimauchi H. Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production // J. Leukoc. Biol. / L. Montaner — Wiley-Blackwell, 2002. — ISSN 0741-5400; 1938-3673 — PMID:12223522
  9. ↑ A Godzik A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2001. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M100354200 — PMID:11279055
  10. ↑ Fauci A. S., M Dybul, AS F. Differential effects of CD40 ligand/trimer stimulation on the ability of dendritic cells to replicate and transmit HIV infection: evidence for CC-chemokine-dependent and -independent mechanisms // J. Immunol. — Baltimore: 1999. — ISSN 0022-1767; 1550-6606 — PMID:10092834
  11. ↑ 11,0 11,1 11,2 Catlett I. M., Bishop G. A. Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2000. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M909520199 — PMID:10748139
  12. ↑ Robinson C. M. Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines // Immunology — Wiley-Blackwell, Wiley, 2014. — ISSN 0019-2805; 1365-2567 — doi:10.1111/IMM.12164 — PMID:23981064
  13. ↑ Buschow S. I., Stoorvogel W., Wauben M. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis // Immunology & Cell Biology — Wiley, 2010. — ISSN 0818-9641; 1440-1711 — doi:10.1038/ICB.2010.64 — PMID:20458337
  14. ↑ Robinson C. M. Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines // Immunology — Wiley-Blackwell, Wiley, 2014. — ISSN 0019-2805; 1365-2567 — doi:10.1111/IMM.12164 — PMID:23981064
  15. ↑ Buschow S. I., Stoorvogel W., Wauben M. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis // Immunology & Cell Biology — Wiley, 2010. — ISSN 0818-9641; 1440-1711 — doi:10.1038/ICB.2010.64 — PMID:20458337
  16. ↑ 16,0 16,1 16,2 16,3 16,4 16,5 16,6 16,7 Ro J. Y. Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L // J. Neuroinflammation — BMC, Springer Science+Business Media, 2011. — ISSN 1742-2094 — doi:10.1186/1742-2094-8-25 — PMID:21410936
  17. ↑ F Pietravalle, S Lecoanet-Henchoz, Aubry J. P. et al. Cleavage of membrane-bound CD40 ligand is not required for inducing B cell proliferation and differentiation // Eur. J. Immunol. — Wiley-Blackwell, 1996. — ISSN 0014-2980; 1521-4141 — doi:10.1002/EJI.1830260333 — PMID:8605945
  18. ↑ D'Agostino R. Expression of the Bcl-2 protein BAD promotes prostate cancer growth // PLOS ONE / PLOS ONE Editors — PLoS, 2009. — ISSN 1932-6203 — doi:10.1371/JOURNAL.PONE.0006224 — PMID:19593445
  19. ↑ Longo C. R. A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis // Circulation — Lippincott Williams & Wilkins, 2003. — ISSN 0009-7322; 1524-4539 — doi:10.1161/01.CIR.0000083718.76889.D0 — PMID:12885753
  20. ↑ Sugano S., Doi T. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways // Oncogene — NPG, 2003. — ISSN 0950-9232; 1476-5594 — doi:10.1038/SJ.ONC.1206406 — PMID:12761501
  21. ↑ I. Stamenkovic, Clark E. A., B. Seed A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas // EMBO J. — NPG, 1989. — ISSN 0261-4189; 1460-2075 — doi:10.1002/(ISSN)1460-2075 — PMID:2475341
  22. ↑ 22,0 22,1 Chun H. J. A PPARγ-dependent miR-424/503-CD40 axis regulates inflammation mediated angiogenesis // Sci. Rep. — Macmillan Publishers, NPG, 2017. — ISSN 2045-2322 — doi:10.1038/S41598-017-02852-4 — PMID:28566713
  23. ↑ I. Stamenkovic, Clark E. A., B. Seed A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas // EMBO J. — NPG, 1989. — ISSN 0261-4189; 1460-2075 — doi:10.1002/(ISSN)1460-2075 — PMID:2475341
  24. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  25. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)

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