CCL3

CCL3
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген CCL3[d][1]
Молекуляр функция protein kinase activity[d][2], cytokine activity[d][3], CCR5 chemokine receptor binding[d][4][5], chemokine activity[d][6][7][8], CCR1 chemokine receptor binding[d][9][10][5][…], kinase activity[d][11], phospholipase activator activity[d][2], calcium-dependent protein kinase C activity[d][10], связывание с белками плазмы[d][12][13][14], связывание похожих белков[d][14], chemoattractant activity[d][15][9][16][…], chemokine activity[d][3][9][16][…] һәм CCR chemokine receptor binding[d][17]
Күзәнәк компоненты цитоплазма[12], цитозоль[d][18], внутренний компонент клетки[d][7], күзәнәк тышындагы өлкә[d][3][3][3][…], күзәнәк тышындагы мохит[d][6][19][20] һәм күзәнәк тышындагы мохит[d][3][21][11][…]
Биологик процесс G protein-coupled receptor signaling pathway[d][17], signaling[d][22], negative regulation of bone mineralization[d][11], позитивная регуляция сигналов от протеинкиназы В[d][11], release of sequestered calcium ion into cytosol by sarcoplasmic reticulum[d][18], response to cholesterol[d][18], positive regulation of calcium-mediated signaling[d][4], regulation of sensory perception of pain[d][10], protein kinase B signaling[d][23], monocyte chemotaxis[d][24][8], negative regulation of osteoclast differentiation[d][11], astrocyte cell migration[d][3], positive regulation of cell migration[d][25][26], positive regulation of natural killer cell chemotaxis[d][26], chemokine-mediated signaling pathway[d][17], T cell chemotaxis[d][25], передача сигнала между клетками[d][4], cellular response to tumor necrosis factor[d][27], eosinophil chemotaxis[d][16], cellular response to organic cyclic compound[d][23], cellular calcium ion homeostasis[d][2][16][11], negative regulation of gene expression[d][11], neutrophil chemotaxis[d][24], cell activation[d][25], MAPK cascade[d][23][22], хемотаксис[d][3][4], positive regulation of GTPase activity[d][17], positive regulation of neuron apoptotic process[d][3], positive regulation of calcium ion import[d][28], macrophage chemotaxis[d][3], positive regulation of gene expression[d][25], cytoskeleton organization[d][16], osteoblast differentiation[d][11], cellular response to interleukin-1[d][27], иммун җавап[d][3], positive regulation of ERK1 and ERK2 cascade[d][20], regulation of cell shape[d][16], positive regulation of tumor necrosis factor production[d][3], cellular response to interferon-gamma[d][27], lymphocyte chemotaxis[d][24], воспалительная реакция[d][6][29][30][…], granulocyte chemotaxis[d][25], response to toxic substance[d][31], eosinophil degranulation[d][25], lipopolysaccharide-mediated signaling pathway[d][23], calcium ion transport[d][2], calcium-mediated signaling[d][16][18], Экзоцитоз[2], positive regulation of calcium ion transport[d][10][5], positive chemotaxis[d][3], positive regulation of inflammatory response[d][6], regulation of signaling receptor activity[d][3], cytokine-mediated signaling pathway[d][3], regulation of behavior[d][21], monocyte chemotaxis[d][25][9][17], воспалительная реакция[d][3][4][25][…], neutrophil chemotaxis[d][25][17], lymphocyte chemotaxis[d][25][17], positive regulation of inflammatory response[d][3][17], positive regulation of ERK1 and ERK2 cascade[d][11][17], cellular response to interferon-gamma[d][32][17], cellular response to interleukin-1[d][32][17], cellular response to tumor necrosis factor[d][32][17], positive regulation of microglial cell activation[d][33] һәм positive regulation of microglial cell migration[d][33]
Изображение Gene Atlas

CCL3 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[34][35]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,0 2,1 2,2 2,3 2,4 Richardson R. M., Pridgen B. C., B Haribabu et al. Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2000. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.275.13.9201 — PMID:10734056
  3. ↑ 3,00 3,01 3,02 3,03 3,04 3,05 3,06 3,07 3,08 3,09 3,10 3,11 3,12 3,13 3,14 3,15 3,16 GOA
  4. ↑ 4,0 4,1 4,2 4,3 4,4 N Reiling Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5 // J. Immunol. — Baltimore: 2000. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.164.5.2592 — PMID:10679098
  5. ↑ 5,0 5,1 5,2 C Combadiere, Ahuja S. K., Tiffany H. L. et al. Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES // J. Leukoc. Biol. / L. Montaner — Wiley-Blackwell, 1996. — ISSN 0741-5400; 1938-3673 — doi:10.1002/JLB.60.1.147 — PMID:8699119
  6. ↑ 6,0 6,1 6,2 6,3 GOA
  7. ↑ 7,0 7,1 Pease J. E. Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways // J. Immunol. — Baltimore: 1999. — ISSN 0022-1767; 1550-6606 — PMID:10072545
  8. ↑ 8,0 8,1 Berkhout T. A., J Gohil, P Gonzalez et al. Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1) // Biochem. Pharmacol. — Elsevier, 2000. — ISSN 0006-2952; 1873-2968 — doi:10.1016/S0006-2952(99)00354-8 — PMID:10660125
  9. ↑ 9,0 9,1 9,2 9,3 Berkhout T. A., J Gohil, P Gonzalez et al. Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1) // Biochem. Pharmacol. — Elsevier, 2000. — ISSN 0006-2952; 1873-2968 — doi:10.1016/S0006-2952(99)00354-8 — PMID:10660125
  10. ↑ 10,0 10,1 10,2 10,3 Zhang N., Inan S., Inan S. et al. A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1 // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 2005. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.0406030102 — PMID:15764707
  11. ↑ 11,0 11,1 11,2 11,3 11,4 11,5 11,6 11,7 11,8 Pozzi S., Patel K. J., P Veiby A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function // Leukemia — NPG, 2011. — ISSN 0887-6924; 1476-5551 — doi:10.1038/LEU.2011.43 — PMID:21403648
  12. ↑ 12,0 12,1 Remaley A. T. Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation // J. Immunol. — Baltimore: 2011. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.1101149 — PMID:21784977
  13. ↑ Couñago R. M., Mercer A. A. Structures of Orf Virus Chemokine Binding Protein in Complex with Host Chemokines Reveal Clues to Broad Binding Specificity // Structure / C. D. Lima — Cell Press, Elsevier, 2015. — ISSN 0969-2126; 1878-4186 — doi:10.1016/J.STR.2015.04.023 — PMID:26095031
  14. ↑ 14,0 14,1 Lenz M., Koenen R. R., Tang W. et al. Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme // EMBO J. — NPG, 2010. — ISSN 0261-4189; 1460-2075 — doi:10.1038/EMBOJ.2010.256 — PMID:20959807
  15. ↑ Na D. S. Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines // FASEB J. — FASEB, 2004. — ISSN 0892-6638; 1530-6860 — doi:10.1096/FJ.03-0867FJE — PMID:15001559
  16. ↑ 16,0 16,1 16,2 16,3 16,4 16,5 16,6 Pease J. E. Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways // J. Immunol. — Baltimore: 1999. — ISSN 0022-1767; 1550-6606 — PMID:10072545
  17. ↑ 17,00 17,01 17,02 17,03 17,04 17,05 17,06 17,07 17,08 17,09 17,10 17,11 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  18. ↑ 18,0 18,1 18,2 18,3 Cardaba C. M., Mueller A. Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells // Biochem. Pharmacol. — Elsevier, 2009. — ISSN 0006-2952; 1873-2968 — doi:10.1016/J.BCP.2009.06.003 — PMID:19523456
  19. ↑ Geppert A. M., Losy J., Przedpelska-Ober E. et al. CCL3 correlates with the number of mood disturbances and personality changes in patients with Alzheimer's disease // Psychiatry Research — Elsevier, 2010. — ISSN 0165-1781; 1872-7123 — doi:10.1016/J.PSYCHRES.2009.02.007 — PMID:20167378
  20. ↑ 20,0 20,1 Pozzi S., Patel K. J., P Veiby A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function // Leukemia — NPG, 2011. — ISSN 0887-6924; 1476-5551 — doi:10.1038/LEU.2011.43 — PMID:21403648
  21. ↑ 21,0 21,1 Geppert A. M., Losy J., Przedpelska-Ober E. et al. CCL3 correlates with the number of mood disturbances and personality changes in patients with Alzheimer's disease // Psychiatry Research — Elsevier, 2010. — ISSN 0165-1781; 1872-7123 — doi:10.1016/J.PSYCHRES.2009.02.007 — PMID:20167378
  22. ↑ 22,0 22,1 Sakai N., Wada T., Furuichi K. et al. p38 MAPK phosphorylation and NF-kappa B activation in human crescentic glomerulonephritis // Nephrol. Dial. Transplant. — OUP, 2002. — ISSN 0931-0509; 1460-2385 — doi:10.1093/NDT/17.6.998 — PMID:12032188
  23. ↑ 23,0 23,1 23,2 23,3 Wu F., Zhang W., Li L. et al. Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells // Eur. J. Pharmacol. — Elsevier, 2011. — ISSN 0014-2999; 1879-0712; 0922-4106 — doi:10.1016/J.EJPHAR.2010.11.022 — PMID:21147091
  24. ↑ 24,0 24,1 24,2 Lee S. C., Brummet M. E., S Shahabuddin et al. Cutaneous injection of human subjects with macrophage inflammatory protein-1 alpha induces significant recruitment of neutrophils and monocytes // J. Immunol. — Baltimore: 2000. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.164.6.3392 — PMID:10706735
  25. ↑ 25,00 25,01 25,02 25,03 25,04 25,05 25,06 25,07 25,08 25,09 Lee S. C., Brummet M. E., S Shahabuddin et al. Cutaneous injection of human subjects with macrophage inflammatory protein-1 alpha induces significant recruitment of neutrophils and monocytes // J. Immunol. — Baltimore: 2000. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.164.6.3392 — PMID:10706735
  26. ↑ 26,0 26,1 A Ben-Baruch, L Xu, Young P. R. et al. Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1995. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.270.38.22123 — PMID:7545673
  27. ↑ 27,0 27,1 27,2 Radeke H. H. Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells // Kidney Int. — NPG, Elsevier, 1997. — ISSN 0085-2538; 1523-1755 — doi:10.1038/KI.1997.482 — PMID:9407497
  28. ↑ H Sano, Hsu D. K., L Yu et al. Human galectin-3 is a novel chemoattractant for monocytes and macrophages // J. Immunol. — Baltimore: 2000. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.165.4.2156 — PMID:10925302
  29. ↑ Wu F., Zhang W., Li L. et al. Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells // Eur. J. Pharmacol. — Elsevier, 2011. — ISSN 0014-2999; 1879-0712; 0922-4106 — doi:10.1016/J.EJPHAR.2010.11.022 — PMID:21147091
  30. ↑ N Reiling Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5 // J. Immunol. — Baltimore: 2000. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.164.5.2592 — PMID:10679098
  31. ↑ Kanki P. J., Essex M. E. In vitro correlates of HIV-2-mediated HIV-1 protection // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 2000. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.97.12.6797 — PMID:10841574
  32. ↑ 32,0 32,1 32,2 Radeke H. H. Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells // Kidney Int. — NPG, Elsevier, 1997. — ISSN 0085-2538; 1523-1755 — doi:10.1038/KI.1997.482 — PMID:9407497
  33. ↑ 33,0 33,1 Piña-Crespo J. C. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function // Neuron / K. Brose — Cell Press, Elsevier, 2018. — ISSN 0896-6273; 1097-4199 — doi:10.1016/J.NEURON.2018.01.031 — PMID:29518356
  34. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  35. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)

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