CCL19

CCL19
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген CCL19[d][1]
Молекуляр функция CCR10 chemokine receptor binding[d][2], cytokine activity[d][3], chemokine receptor binding[d][4], CCR7 chemokine receptor binding[d][3], chemokine activity[d][5][6], CCR chemokine receptor binding[d][7], связывание с белками плазмы[d][8], chemokine activity[d][3][9][10] һәм CCR chemokine receptor binding[d][11][10]
Күзәнәк компоненты күзәнәк тышындагы өлкә[d][3][3][3], внутренний компонент клетки[d][5] һәм күзәнәк тышындагы мохит[d][3][10]
Биологик процесс release of sequestered calcium ion into cytosol[d][12], positive regulation of receptor-mediated endocytosis[d][3], позитивная регуляция сигналов от протеинкиназы В[d][9][13], positive regulation of cell motility[d][9], positive regulation of dendritic cell dendrite assembly[d][3], positive regulation of interleukin-12 production[d][3], regulation of cell projection assembly[d][3], monocyte chemotaxis[d][10], positive regulation of T-helper 1 cell differentiation[d][3], chemokine-mediated signaling pathway[d][10], response to nitric oxide[d][14], cellular response to tumor necrosis factor[d][10], T cell costimulation[d][3], response to virus[d][15], cellular calcium ion homeostasis[d][15], cell maturation[d][3], myeloid dendritic cell chemotaxis[d][12], positive regulation of JNK cascade[d][9], dendritic cell chemotaxis[d][9], positive regulation of phosphatidylinositol 3-kinase activity[d][9][13], хемотаксис[d][3], клеточная коммуникация[d][15], positive regulation of endocytosis[d][3], positive regulation of GTPase activity[d][3][10], response to prostaglandin E[d][12], positive regulation of dendritic cell antigen processing and presentation[d][3], positive regulation of chemotaxis[d][3], cellular response to interleukin-1[d][10], positive regulation of T cell proliferation[d][3], иммун җавап[d][16][3], positive regulation of ERK1 and ERK2 cascade[d][17][6], establishment of T cell polarity[d][18], positive regulation of glycoprotein biosynthetic process[d][3], cellular response to interferon-gamma[d][10], positive regulation of tumor necrosis factor production[d][3], positive regulation of I-kappaB kinase/NF-kappaB signaling[d][13], lymphocyte chemotaxis[d][10], positive regulation of neutrophil chemotaxis[d][19], воспалительная реакция[d][12][3][10], immunological synapse formation[d][3], mature conventional dendritic cell differentiation[d][3], positive regulation of protein kinase activity[d][12][13], antimicrobial humoral immune response mediated by antimicrobial peptide[d][20], regulation of signaling receptor activity[d][3], G protein-coupled receptor signaling pathway[d][3][10], negative regulation of dendritic cell apoptotic process[d][13], cytokine-mediated signaling pathway[d][3], positive regulation of NIK/NF-kappaB signaling[d][13], neutrophil chemotaxis[d][10] һәм positive regulation of ERK1 and ERK2 cascade[d][21][9][10]
Изображение Gene Atlas

CCL19 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[22][23]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ J Gosling, Dairaghi D. J., Y Wang et al. Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK // J. Immunol. — Baltimore: 2000. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.164.6.2851 — PMID:10706668
  3. ↑ 3,00 3,01 3,02 3,03 3,04 3,05 3,06 3,07 3,08 3,09 3,10 3,11 3,12 3,13 3,14 3,15 3,16 3,17 3,18 3,19 3,20 3,21 3,22 3,23 3,24 3,25 3,26 3,27 3,28 GOA
  4. ↑ Smit M. J. β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR, β-Arrestin Recruitment and G Protein Signaling by the Atypical Human Chemokine Decoy Receptor CCX-CKR // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2013. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M112.406108 — PMID:23341447
  5. ↑ 5,0 5,1 GOA
  6. ↑ 6,0 6,1 Corbí A. L., Sánchez-mateos P., Rodríguez-Fernández J. L. The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed // J. Immunol. — Baltimore: 2005. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.174.7.4070 — PMID:15778365
  7. ↑ Catusse J., Hartmann T. N., Nibbs R. J. et al. CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B // Immunology — Wiley-Blackwell, Wiley, 2010. — ISSN 0019-2805; 1365-2567 — doi:10.1111/J.1365-2567.2009.03209.X — PMID:20002784
  8. ↑ Dyer D. P. The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2016. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M116.720953 — PMID:27044744
  9. ↑ 9,0 9,1 9,2 9,3 9,4 9,5 9,6 Corbí A. L., Sánchez-mateos P., Rodríguez-Fernández J. L. The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed // J. Immunol. — Baltimore: 2005. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.174.7.4070 — PMID:15778365
  10. ↑ 10,00 10,01 10,02 10,03 10,04 10,05 10,06 10,07 10,08 10,09 10,10 10,11 10,12 10,13 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  11. ↑ Catusse J., Hartmann T. N., Nibbs R. J. et al. CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B // Immunology — Wiley-Blackwell, Wiley, 2010. — ISSN 0019-2805; 1365-2567 — doi:10.1111/J.1365-2567.2009.03209.X — PMID:20002784
  12. ↑ 12,0 12,1 12,2 12,3 12,4 Scandella E., Groettrup M., Ludewig B. et al. CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2 // Blood — American Society of Hematology, Elsevier, 2004. — ISSN 0006-4971; 1528-0020 — doi:10.1182/BLOOD-2003-05-1643 — PMID:14592837
  13. ↑ 13,0 13,1 13,2 13,3 13,4 13,5 Cuadrado A., Cabanas C., Corbí A. L. et al. Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells // Blood — American Society of Hematology, Elsevier, 2004. — ISSN 0006-4971; 1528-0020 — doi:10.1182/BLOOD-2003-11-3943 — PMID:15059845
  14. ↑ Clark E. A. Nitric oxide and cGMP protein kinase (cGK) regulate dendritic-cell migration toward the lymph-node-directing chemokine CCL19 // Blood — American Society of Hematology, Elsevier, 2006. — ISSN 0006-4971; 1528-0020 — doi:10.1182/BLOOD-2005-07-2901 — PMID:16249377
  15. ↑ 15,0 15,1 15,2 Nomiyama H. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1997. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.272.21.13803 — PMID:9153236
  16. ↑ F Annunziato, P Romagnani, L Cosmi et al. Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection // J. Immunol. — Baltimore: 2000. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.165.1.238 — PMID:10861057
  17. ↑ Ho L. Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus, Up‐regulation of galectin‐9 induces cell migration in human dendritic cells infected with dengue virus // J Cell Mol Med, or JCMM — Wiley-Blackwell, Wiley, 2015. — ISSN 1582-1838; 1582-4934; 1453-1321 — doi:10.1111/JCMM.12500 — PMID:25754930
  18. ↑ Bardi G. Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes, Rho kinase is required for CCR7‐mediated polarization and chemotaxis of T lymphocytes // FEBS Letters — Elsevier, 2003. — ISSN 0014-5793; 1873-3468 — doi:10.1016/S0014-5793(03)00351-X — PMID:12729902
  19. ↑ Jaillon S., Doni A. CCR7 is involved in the migration of neutrophils to lymph nodes // Blood — American Society of Hematology, Elsevier, 2011. — ISSN 0006-4971; 1528-0020 — doi:10.1182/BLOOD-2009-11-254490 — PMID:21051556
  20. ↑ Yang D., Chen Q., Hoover D. M. et al. Many chemokines including CCL20/MIP-3alpha display antimicrobial activity // J. Leukoc. Biol. / L. Montaner — Wiley-Blackwell, 2003. — ISSN 0741-5400; 1938-3673 — doi:10.1189/JLB.0103024 — PMID:12949249
  21. ↑ Ho L. Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus, Up‐regulation of galectin‐9 induces cell migration in human dendritic cells infected with dengue virus // J Cell Mol Med, or JCMM — Wiley-Blackwell, Wiley, 2015. — ISSN 1582-1838; 1582-4934; 1453-1321 — doi:10.1111/JCMM.12500 — PMID:25754930
  22. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  23. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.