BCHE

BCHE
Рәсем
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген Бутирилхолинэстераза[d][1]
Молекуляр функция carboxylic ester hydrolase activity[d][2], amyloid-beta binding[d][3], cholinesterase activity[d][4][2][2][…], choline binding[d][2], активность катализатора[d][3], связывание похожих белков[d][5][6][7][…], acetylcholinesterase activity[d][2][2], enzyme binding[d][3], гидролазная активность[d][2] һәм hydrolase activity, acting on ester bonds[d][8]
Күзәнәк компоненты endoplasmic reticulum lumen[d][2], blood microparticle[d][9], мембрана[d][2], күзәнәк тышындагы өлкә[d][2][10][2], эндоплазматик челтәр[2], nuclear envelope lumen[d][2], күзәнәк тышындагы мохит[d][2] һәм blood microparticle[d][11]
Биологик процесс choline metabolic process[d][2], response to nutrient[d][2], neuroblast differentiation[d][2], response to glucocorticoid[d][2], negative regulation of synaptic transmission[d][2], белем алу[2], cocaine metabolic process[d][12], response to alkaloid[d][2], response to folic acid[d][2] һәм негативная регуляция пролиферации клеток[d][2]
Тәэсир итешә bambuterol[d][13], физостигмин[d][13], пиридостигмина бромид[d][13], ривастигмин[d][13] һәм такрин[d][13]

BCHE (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[14][15]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 2,19 2,20 2,21 2,22 GOA
  3. ↑ 3,0 3,1 3,2 Darvesh S., Walsh R. Butyrylcholinesterase-Mediated enhancement of the enzymatic activity of trypsin // Cellular and Molecular Neurobiology — Springer Science+Business Media, 2001. — ISSN 0272-4340; 1573-6830 — doi:10.1023/A:1010947205224 — PMID:11569538
  4. ↑ Nogueira C. P., McGuire M. C., C Graeser et al. Identification of a frameshift mutation responsible for the silent phenotype of human serum cholinesterase, Gly 117 (GGT----GGAG) // Am. J. Hum. Genet. — Cell Press, Elsevier, 1990. — ISSN 0002-9297; 1537-6605 — PMID:2339692
  5. ↑ Brazzolotto X., Ronco C., Jean L. et al. Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure // FEBS J. — Wiley-Blackwell, 2012. — ISSN 1742-464X; 1742-4658 — doi:10.1111/J.1742-4658.2012.08672.X — PMID:22726956
  6. ↑ Leduc M., Bilodeau A. S. Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 2007. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.0702756104 — PMID:17660298
  7. ↑ C. Linn Cadieux, Soreq H. Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 2010. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.1009021107 — PMID:21059932
  8. ↑ GOA
  9. ↑ Bastos-Amador P., González E., Conde-Vancells J. et al. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability // Journal of Proteomics — Elsevier, 2012. — ISSN 1874-3919; 0165-022X — doi:10.1016/J.JPROT.2012.03.054 — PMID:22516433
  10. ↑ Pounds J. G. The human plasma proteome: a nonredundant list developed by combination of four separate sources // Mol. Cell. Proteomics — American Society for Biochemistry and Molecular Biology, 2004. — ISSN 1535-9476; 1535-9484 — doi:10.1074/MCP.M300127-MCP200 — PMID:14718574
  11. ↑ Bastos-Amador P., González E., Conde-Vancells J. et al. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability // Journal of Proteomics — Elsevier, 2012. — ISSN 1874-3919; 0165-022X — doi:10.1016/J.JPROT.2012.03.054 — PMID:22516433
  12. ↑ C Mattes, R Bradley, E Slaughter et al. Cocaine and butyrylcholinesterase (BChE): determination of enzymatic parameters // Life Sci. — Elsevier, 1996. — ISSN 0024-3205; 1879-0631 — doi:10.1016/0024-3205(96)00065-3 — PMID:8622553
  13. ↑ 13,0 13,1 13,2 13,3 13,4 IUPHAR/BPS Guide to PHARMACOLOGY
  14. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  15. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)

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