ATXN2

ATXN2
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген ATXN2[d][1]
Молекуляр функция epidermal growth factor receptor binding[d][2], protein C-terminus binding[d][3], связывание с белками плазмы[d][4][5][6][…], RNA binding[d][7][8][9][…] һәм RNA binding[d][4][10][11]
Күзәнәк компоненты цитоплазма[12][4][13][…], perinuclear region of cytoplasm[d][5], Полисома[d][14], trans-Golgi network[d][4], Гольджи аппараты[5][15], cytoplasmic stress granule[d][16], мембрана[d][17], цитозоль[d][12], cytoplasmic stress granule[d][13][18], мембрана[d][19] һәм рибонуклеопротеин[d][14]
Биологик процесс regulation of cytoplasmic mRNA processing body assembly[d][18], stress granule assembly[d][16], процесс метаболизма РНК[d][3], regulation of translation[d][14], P-body assembly[d][13], перенос РНК[d][4], negative regulation of receptor internalization[d][2] һәм stress granule assembly[d][13][18]

ATXN2 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[20][21]

Искәрмәләр

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,0 2,1 Dikic I., Mirko H H Schmidt Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking // Cell. Signal. — Elsevier, 2008. — ISSN 0898-6568; 1873-3913 — doi:10.1016/J.CELLSIG.2008.05.018 — PMID:18602463
  3. ↑ 3,0 3,1 Lehrach H., Ralser M., Krobitsch S. et al. An integrative approach to gain insights into the cellular function of human ataxin-2 // Journal of Molecular Biology / P. Wright — Elsevier, 2005. — ISSN 0022-2836; 1089-8638 — doi:10.1016/J.JMB.2004.11.024 — PMID:15663938
  4. ↑ 4,0 4,1 4,2 4,3 4,4 H Shibata, Huynh D. P., Pulst S. M. A novel protein with RNA-binding motifs interacts with ataxin-2 // Human Molecular Genetics — OUP, 2000. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/9.9.1303 — PMID:10814712
  5. ↑ 5,0 5,1 5,2 Brice A. Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death // Exp. Neurol. — Elsevier, 2007. — ISSN 0014-4886; 1090-2430; 1055-8330; 1522-9661 — doi:10.1016/J.EXPNEUROL.2006.09.009 — PMID:17097639
  6. ↑ Hart M. P., Johnson B. S., Trojanowski J. Q. et al. Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS // Nature / M. Skipper — NPG, Springer Science+Business Media, 2010. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE09320 — PMID:20740007
  7. ↑ H Shibata, Huynh D. P., Pulst S. M. A novel protein with RNA-binding motifs interacts with ataxin-2 // Human Molecular Genetics — OUP, 2000. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/9.9.1303 — PMID:10814712
  8. ↑ Preiss T., Beckmann B. M., Humphreys D. T. et al. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins // Cell — Cell Press, Elsevier, 2012. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2012.04.031 — PMID:22658674
  9. ↑ Bonneau R., Munschauer M., Drew K. et al. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts, The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts // Mol. Cell — Cell Press, Elsevier, 2012. — ISSN 1097-2765; 1097-4164 — doi:10.1016/J.MOLCEL.2012.05.021 — PMID:22681889
  10. ↑ Bonneau R., Munschauer M., Drew K. et al. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts, The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts // Mol. Cell — Cell Press, Elsevier, 2012. — ISSN 1097-2765; 1097-4164 — doi:10.1016/J.MOLCEL.2012.05.021 — PMID:22681889
  11. ↑ Preiss T., Beckmann B. M., Humphreys D. T. et al. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins // Cell — Cell Press, Elsevier, 2012. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2012.04.031 — PMID:22658674
  12. ↑ 12,0 12,1 GOA
  13. ↑ 13,0 13,1 13,2 13,3 Lehrach H., Ralser M., Krobitsch S. et al. Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules // Mol. Biol. Cell, — American Society for Cell Biology, 2007. — ISSN 1059-1524; 1939-4586; 1044-2030 — doi:10.1091/MBC.E06-12-1120 — PMID:17392519
  14. ↑ 14,0 14,1 14,2 Satterfield T. F., Pallanck L. J. Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes // Human Molecular Genetics — OUP, 2006. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/DDL173 — PMID:16835262
  15. ↑ Huynh D. P., Yang H., Vakharia H. et al. Expansion of the polyQ repeat in ataxin-2 alters its Golgi localization, disrupts the Golgi complex and causes cell death // Human Molecular Genetics — OUP, 2003. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/DDG175 — PMID:12812977
  16. ↑ 16,0 16,1 Lehrach H., Ralser M., Krobitsch S. et al. Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules // Mol. Biol. Cell, — American Society for Cell Biology, 2007. — ISSN 1059-1524; 1939-4586; 1044-2030 — doi:10.1091/MBC.E06-12-1120 — PMID:17392519
  17. ↑ Lippert D. Defining the membrane proteome of NK cells // J. Mass Spectrom. — Wiley, 2010. — ISSN 1076-5174; 1096-9888 — doi:10.1002/JMS.1696 — PMID:19946888
  18. ↑ 18,0 18,1 18,2 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  19. ↑ Lippert D. Defining the membrane proteome of NK cells // J. Mass Spectrom. — Wiley, 2010. — ISSN 1076-5174; 1096-9888 — doi:10.1002/JMS.1696 — PMID:19946888
  20. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  21. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)

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