RBL2
| Ретинобластомоподобный белок 2 | |||||||||||
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| Идентификаторы | |||||||||||
| Символ | RBL2 ; P130; Rb2 | ||||||||||
| Внешние ID | OMIM: 180203 MGI: 105085 HomoloGene: 4098 GeneCards: Ген RBL2 | ||||||||||
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| Профиль экспрессии РНК | |||||||||||
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| Больше информации | |||||||||||
| Ортологи | |||||||||||
| Вид | Человек | Мышь | |||||||||
| Entrez | 5934 | 19651 | |||||||||
| Ensembl | ENSG00000103479 | ENSMUSG00000031666 | |||||||||
| UniProt | Q08999 | Q64700 | |||||||||
| RefSeq (мРНК) | NM_005611 | NM_001282000 | |||||||||
| RefSeq (белок) | NP_005602 | NP_001268929 | |||||||||
| Локус (UCSC) | Chr 16: 53.47 – 53.53 Mb |
Chr 8: 91.07 – 91.12 Mb |
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| Поиск в PubMed | Искать | Искать | |||||||||
Ретинобластомоподобный белок 2 — белок, который у человека, кодируется геном RBL2[1][2].
Взаимодействия
Ретинобластомоподобный белок 2, как было выявлено, взаимодействует с HDAC1,[3][4] c-Raf,[5] RBBP8[англ.],[6][7] циклином Е1,[8][9] прохибитином,[10] циклинозависимой киназой 2,[8][11] BRF1[англ.][12] и BRCA1.[13]
См. также
Примечания
- ↑ Mayol X., Grana X., Baldi A., Sang N., Hu Q., Giordano A. Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain (англ.) // Oncogene : journal. — 1993. — September (vol. 8, no. 9). — P. 2561—2566. — PMID 8361765.
- ↑ Baldi A., Boccia V., Claudio P.P., De Luca A., Giordano A. Genomic structure of the human retinoblastoma-related Rb2/p130 gene (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1996. — July (vol. 93, no. 10). — P. 4629—4632. — doi:10.1073/pnas.93.10.4629. — PMID 8643454. — PMC 39329.
- ↑ Ferreira, R; Magnaghi-Jaulin L; Robin P; Harel-Bellan A; Trouche D. The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — UNITED STATES, 1998. — September (vol. 95, no. 18). — P. 10493—10498. — ISSN 0027-8424. — doi:10.1073/pnas.95.18.10493. — PMID 9724731. — PMC 27922.
- ↑ Bouzahzah, B; Fu M; Iavarone A; Factor V M; Thorgeirsson S S; Pestell R G. Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo (англ.) // Cancer Res. : journal. — UNITED STATES, 2000. — August (vol. 60, no. 16). — P. 4531—4537. — ISSN 0008-5472. — PMID 10969803.
- ↑ Wang, S; Ghosh R N; Chellappan S P. Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation (англ.) // Mol. Cell. Biol. : journal. — UNITED STATES, 1998. — December (vol. 18, no. 12). — P. 7487—7498. — ISSN 0270-7306. — PMID 9819434. — PMC 109329.
- ↑ Meloni, A R; Smith E J; Nevins J R. A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — UNITED STATES, 1999. — August (vol. 96, no. 17). — P. 9574—9579. — ISSN 0027-8424. — doi:10.1073/pnas.96.17.9574. — PMID 10449734. — PMC 22250.
- ↑ Fusco, C; Reymond A; Zervos A S. Molecular cloning and characterization of a novel retinoblastoma-binding protein (англ.) // Genomics : journal. — UNITED STATES: Academic Press, 1998. — August (vol. 51, no. 3). — P. 351—358. — ISSN 0888-7543. — doi:10.1006/geno.1998.5368. — PMID 9721205.
- ↑ 1 2 Shanahan, F; Seghezzi W; Parry D; Mahony D; Lees E. Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest (англ.) // Mol. Cell. Biol. : journal. — UNITED STATES, 1999. — February (vol. 19, no. 2). — P. 1460—1469. — ISSN 0270-7306. — PMID 9891079. — PMC 116074.
- ↑ Li, Y; Graham C; Lacy S; Duncan A M; Whyte P. The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E (англ.) // Genes Dev. : journal. — UNITED STATES, 1993. — December (vol. 7, no. 12A). — P. 2366—2377. — ISSN 0890-9369. — doi:10.1101/gad.7.12a.2366. — PMID 8253383.
- ↑ Wang, S; Nath N; Adlam M; Chellappan S. Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function (англ.) // Oncogene : journal. — ENGLAND, 1999. — June (vol. 18, no. 23). — P. 3501—3510. — ISSN 0950-9232. — doi:10.1038/sj.onc.1202684. — PMID 10376528.
- ↑ Lacy, S; Whyte P. Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes (англ.) // Oncogene : journal. — ENGLAND, 1997. — May (vol. 14, no. 20). — P. 2395—2406. — ISSN 0950-9232. — doi:10.1038/sj.onc.1201085. — PMID 9188854.
- ↑ Sutcliffe, J E; Cairns C A; McLees A; Allison S J; Tosh K; White R J. RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130 (англ.) // Mol. Cell. Biol. : journal. — UNITED STATES, 1999. — June (vol. 19, no. 6). — P. 4255—4261. — ISSN 0270-7306. — PMID 10330166. — PMC 104385.
- ↑ Fan, S; Yuan R; Ma Y X; Xiong J; Meng Q; Erdos M; Zhao J N; Goldberg I D; Pestell R G; Rosen E M. Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding (англ.) // Oncogene : journal. — England, 2001. — August (vol. 20, no. 35). — P. 4827—4841. — ISSN 0950-9232. — doi:10.1038/sj.onc.1204666. — PMID 11521194.
Литература
- Soprano K.J., Purev E., Vuocolo S., Soprano D.R. Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid. (англ.) // Oncogene : journal. — 2006. — Vol. 25, no. 38. — P. 5315—5325. — doi:10.1038/sj.onc.1209679. — PMID 16936753.
- De Falco G., Giordano A. pRb2/p130: a new candidate for retinoblastoma tumor formation. (англ.) // Oncogene : journal. — 2006. — Vol. 25, no. 38. — P. 5333—5340. — doi:10.1038/sj.onc.1209614. — PMID 16936755.
- Hijmans E.M., Voorhoeve P.M., Beijersbergen R.L., et al. E2F-5, a new E2F family member that interacts with p130 in vivo. (англ.) // Mol. Cell. Biol. : journal. — 1995. — Vol. 15, no. 6. — P. 3082—3089. — PMID 7760804. — PMC 230539.
- Sardet C., Vidal M., Cobrinik D., et al. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1995. — Vol. 92, no. 6. — P. 2403—2407. — doi:10.1073/pnas.92.6.2403. — PMID 7892279. — PMC 42492.
- Yeung R.S., Bell D.W., Testa J.R., et al. The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19. (англ.) // Oncogene : journal. — 1993. — Vol. 8, no. 12. — P. 3465—3468. — PMID 8247552.
- Li Y., Graham C., Lacy S., et al. The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. (англ.) // Genes Dev. : journal. — 1994. — Vol. 7, no. 12A. — P. 2366—2377. — doi:10.1101/gad.7.12a.2366. — PMID 8253383.
- Hannon G.J., Demetrick D., Beach D. Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. (англ.) // Genes Dev. : journal. — 1994. — Vol. 7, no. 12A. — P. 2378—2391. — doi:10.1101/gad.7.12a.2378. — PMID 8253384.
- Lavender P., Vandel L., Bannister A.J., Kouzarides T. The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A. (англ.) // Oncogene : journal. — 1997. — Vol. 14, no. 22. — P. 2721—2728. — doi:10.1038/sj.onc.1201243. — PMID 9178770.
- Lacy S., Whyte P. Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes. (англ.) // Oncogene : journal. — 1997. — Vol. 14, no. 20. — P. 2395—2406. — doi:10.1038/sj.onc.1201085. — PMID 9188854.
- Shao Z., Siegert J.L., Ruppert S., Robbins P.D. Rb interacts with TAF(II)250/TFIID through multiple domains. (англ.) // Oncogene : journal. — 1997. — Vol. 15, no. 4. — P. 385—392. — doi:10.1038/sj.onc.1201204. — PMID 9242374.
- Sterner J.M., Dew-Knight S., Musahl C., et al. Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. (англ.) // Mol. Cell. Biol. : journal. — 1998. — Vol. 18, no. 5. — P. 2748—2757. — PMID 9566894. — PMC 110654.
- Woitach J.T., Zhang M., Niu C.H., Thorgeirsson S.S. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. (англ.) // Nat. Genet. : journal. — 1998. — Vol. 19, no. 4. — P. 371—374. — doi:10.1038/1258. — PMID 9697699.
- Veal E., Eisenstein M., Tseng Z.H., Gill G. A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. (англ.) // Mol. Cell. Biol. : journal. — 1998. — Vol. 18, no. 9. — P. 5032—5041. — PMID 9710587. — PMC 109088.
- Fusco C., Reymond A., Zervos A.S. Molecular cloning and characterization of a novel retinoblastoma-binding protein. (англ.) // Genomics : journal. — Academic Press, 1998. — Vol. 51, no. 3. — P. 351—358. — doi:10.1006/geno.1998.5368. — PMID 9721205.
- Ferreira R., Magnaghi-Jaulin L., Robin P., et al. The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1998. — Vol. 95, no. 18. — P. 10493—10498. — doi:10.1073/pnas.95.18.10493. — PMID 9724731. — PMC 27922.
- Paramio J.M., Laín S., Segrelles C., et al. Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation. (англ.) // Oncogene : journal. — 1998. — Vol. 17, no. 8. — P. 949—957. — doi:10.1038/sj.onc.1202031. — PMID 9747874.
- Wang S., Ghosh R.N., Chellappan S.P. Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation. (англ.) // Mol. Cell. Biol. : journal. — 1998. — Vol. 18, no. 12. — P. 7487—7498. — PMID 9819434. — PMC 109329.
- Yang R., Müller C., Huynh V., et al. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. (англ.) // Mol. Cell. Biol. : journal. — 1999. — Vol. 19, no. 3. — P. 2400—2407. — PMID 10022926. — PMC 84032.
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