ZXDC

O ZXDC (do inglês: Zinc finger, X-linked, duplicated family member C), é uma proteína humana de ligação ao CIITA envolvida na ativação do complexo principal de histocompatibilidade (MHC) classe I e II.[1] Para que a ligação ocorra, o ZXDC deve formar um complexo oligomérico com outra cópia de si mesmo ou com o ZXDA, uma proteína relacionada.[2] ZXDC é ativado por sumoilação, uma modificação pós-traducional.[3]

Referências

  1. ↑ «ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription». Molecular Immunology. 44. PMC 1624858Acessível livremente. PMID 16600381. doi:10.1016/j.molimm.2006.02.029 
  2. ↑ «The Zinc Finger Proteins ZXDA and ZXDC Form a Complex that Binds CIITA and Regulates MHC II Gene Transcription». Journal of Molecular Biology. 369. PMC 1963517Acessível livremente. PMID 17493635. doi:10.1016/j.jmb.2007.04.033 
  3. ↑ «Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain». Biological Chemistry. 388. PMID 17696781. doi:10.1515/BC.2007.106 

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