Receptor de rianodina

Rianodina

Os receptores de rianodina formam uma classe de canais de cálcio intracelulares encontrados em várias formas de tecido animal excitável, como músculos e neurónios. É um importante mediador da libertação de cálcio induzida por cálcio em células animais.

Etimologia

Os receptores tomam o nome de um alcalóide vegetal, a rianodina, para o qual mostram alta afinidade.

Isoformas

Existem múltiplas isoformas de receptores de rianodina:

  • RyR1, principalmente expressa no músculo esquelético;
  • RyR2, no miocárdio;
  • Uma terceira forma, RyR3, é expressa de maneira mais ampla, mas especialmente no cérebro[1];
  • Existe uma quarta forma encontrada em peixes.

Referências

  1. ↑ Zucchi R, Ronca-Testoni S. The sarcoplasmic reticulum Ca2+ channel/ryanodine receptor: modulation by endogenous effectors, drugs, and disease states. Pharmacol Rev 1997;49:1-51. PMID 9085308.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.