Lipase lisossomal

Lipase lisossomal
Indicadores
SímboloLIPA
HUGO6617
Entrez3988
OMIM278000
RefSeqNM_000235
UniProtP38571
Outros dados
Número EC3.1.1.13
LocusCr. 10 q23.2-23.3

A lipase lisossomal é uma forma de lipase que funcional de forma intracelular, no lisossoma.

Importância clínica

Está associada à deficiência de lipase ácida lisossomal, à doença de Wolman e à doença de armazenamento dos ésteres do colesterol.

A substância clorpromazina é inibidora da lipase lisossomal.[1]

Um rastreio genético sugere que a lipase lisossomal A, localizada como cromossoma 10q23.31, está associada com a doença arterial coronariana em humanos.[2]

Referências

  1. ↑ Sauro VS, Klamut HJ, Lin CH, Strickland KP (1985). «Lysosomal triacylglycerol lipase activity in L6 myoblasts and its changes on differentiation». Biochem. J. 227 (2): 583–9. PMC 1144878Acessível livremente. PMID 4004781 
  2. ↑ Wild PS, Zeller T, Schillert A; et al. (maio de 2011). «A Genome-wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease». Circ Cardiovasc Genet. 4 (4): 403–12. PMC 3157552Acessível livremente. PMID 21606135. doi:10.1161/CIRCGENETICS.110.958728. Consultado em 14 de janeiro de 2015. Arquivado do original em 23 de fevereiro de 2013 

Ligações externas

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