HIST1H2BJ
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A Histona H2B tipo 1-J é uma proteína que em humanos é codificada pelo gene HIST1H2BJ.[2][3][4]
As histonas são proteínas nucleares básicas que são responsáveis pela estrutura dos nucleossomos da fibra cromossômica nos eucariotos. Duas moléculas de cada uma das quatro histonas do núcleo (H2A, H2B, H3 e H4) formam um octâmero, em torno do qual aproximadamente 146 pb de DNA é envolvido em unidades repetidas, chamadas nucleossomos. A histona ligante, H1, interage com o DNA ligante entre nucleossomos e funciona na compactação da cromatina em estruturas de ordem superior. Este gene é desprovido de intrones e codifica um membro da família histona H2B. Os transcritos desse gene não possuem caudas de poli A, mas contêm um elemento de terminação palindrômico. Este gene é encontrado no pequeno agrupamento de genes de histonas no cromossomo 6p22-p21.3.[4]
Referências
- ↑ «Human PubMed Reference:»
- ↑ Zhong R, Roeder RG, Heintz N (janeiro de 1984). «The primary structure and expression of four cloned human histone genes». Nucleic Acids Res. 11 (21): 7409–7425. PMC 326492
. PMID 6647026. doi:10.1093/nar/11.21.7409
- ↑ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (outubro de 2002). «The human and mouse replication-dependent histone genes». Genomics. 80 (5): 487–498. PMID 12408966. doi:10.1016/S0888-7543(02)96850-3
- ↑ a b «Entrez Gene: HIST1H2BJ histone cluster 1, H2bj»
Leitura adicional
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- Mungall AJ, Palmer SA, Sims SK, et al. (2003). «The DNA sequence and analysis of human chromosome 6». Nature. 425 (6960): 805–811. PMID 14574404. doi:10.1038/nature02055 line feed character character in
|último4=at position 546 (ajuda) - Lusic M, Marcello A, Cereseto A, Giacca M (2004). «Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter». EMBO J. 22 (24): 6550–6561. PMC 291826. PMID 14657027. doi:10.1093/emboj/cdg631
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co|vauthors=Howell SJ, Wilk D, Yadav SP, Bevins CL |título=Antimicrobial polypeptides of the human colonic epithelium |periódico=Peptides |volume=24 |número= 11 |pages= 1763–1770 |ano= 2004 |pmid= 15019208 |doi= 10.1016/j.peptides.2003.07.028 }}
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