GCM1
O fator de transcrição específico para coros GCMa é uma proteína que, em humanos, é codificada pelo gene GCM1.[1][2]
Esse gene codifica uma proteína de ligação ao DNA com um motivo gcm (motivo que falta às células da glia). A proteína codificada é um homólogo do gene ausente das células gliais de Drosophila (gcm). Esta proteína se liga ao motivo GCM (A/G)CCCGCAT, uma nova sequência entre os alvos conhecidos das proteínas de ligação ao DNA. O domínio de ligação ao DNA do terminal N confere a atividade única de ligação ao DNA desta proteína.[2]
Referências
- ↑ Akiyama Y, Hosoya T, Poole AM, Hotta Y. «The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals». Proc Natl Acad Sci U S A. 93: 14912–6. PMC 26236
. PMID 8962155. doi:10.1073/pnas.93.25.14912
- ↑ a b «Entrez Gene: GCM1 glial cells missing homolog 1 (Drosophila)»
Leitura adicional
- «A GCM motif protein is involved in placenta-specific expression of human aromatase gene.». J. Biol. Chem. 274: 32279–86. 1999. PMID 10542267. doi:10.1074/jbc.274.45.32279
- Nait-Oumesmar B, Copperman AB, Lazzarini RA (2000). «Placental expression and chromosomal localization of the human Gcm 1 gene.». J. Histochem. Cytochem. 48: 915–22. PMID 10858268. doi:10.1177/002215540004800704
- «Genomic organization, chromosomal localization, and the complete 22 kb DNA sequence of the human GCMa/GCM1, a placenta-specific transcription factor gene.». Biochem. Biophys. Res. Commun. 278: 134–9. 2001. PMID 11071865. doi:10.1006/bbrc.2000.3775
- «GCMa regulates the syncytin-mediated trophoblastic fusion.». J. Biol. Chem. 277: 50062–8. 2003. PMID 12397062. doi:10.1074/jbc.M209316200
- «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99: 16899–903. 2003. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
- «The DNA sequence and analysis of human chromosome 6.». Nature. 425: 805–11. 2003. PMID 14574404. doi:10.1038/nature02055
- «Decreased placental GCM1 (glial cells missing) gene expression in pre-eclampsia.». Placenta. 25: 413–21. 2005. PMID 15081636. doi:10.1016/j.placenta.2003.10.014
- «Complex patterns of GCM1 mRNA and protein in villous and extravillous trophoblast cells of the human placenta.». Placenta. 25: 553–9. 2004. PMID 15135239. doi:10.1016/j.placenta.2003.12.004
- «Interaction, cooperative promoter modulation, and renal colocalization of GCMa and Pitx2.». J. Biol. Chem. 279: 50358–65. 2005. PMID 15385555. doi:10.1074/jbc.M404587200
- «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14: 2121–7. 2004. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
- «FBW2 targets GCMa to the ubiquitin-proteasome degradation system.». J. Biol. Chem. 280: 10083–90. 2005. PMID 15640526. doi:10.1074/jbc.M413986200
- «Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions.». FEBS Lett. 579: 3991–8. 2005. PMID 16004993. doi:10.1016/j.febslet.2005.06.029
- «Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.». Mol. Cell. Biol. 25: 8401–14. 2005. PMC 1265739. PMID 16166624. doi:10.1128/MCB.25.19.8401-8414.2005
- «Histone deacetylase 3 binds to and regulates the GCMa transcription factor.». Nucleic Acids Res. 34: 1459–69. 2006. PMC 1401512. PMID 16528103. doi:10.1093/nar/gkl048
- «Increased plasma mRNAs of placenta-specific 1 (PLAC1) and glial cells-missing 1 (GCM1) in mothers with pre-eclampsia.». Hiroshima J. Med. Sci. 55: 9–15. 2007. PMID 16594548
- «Small ubiquitin-like modifier modification regulates the DNA binding activity of glial cell missing Drosophila homolog a.». J. Biol. Chem. 282: 27239–49. 2007. PMID 17646165. doi:10.1074/jbc.M700351200
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