ENPP3

ENPP3
Identificadores
Nomes alternativosENPP3
IDs externosOMIM: 602182 HomoloGene: 3683 GeneCards: ENPP3
Wikidata
Ver/Editar Humano

O ectonucleotídeo pirofosfatase/fosfodiesterase membro da família 3 é uma enzima que em humanos é codificada pelo gene ENPP3.[2][3]

Função

A proteína codificada por esse gene pertence a uma série de ectoenzimas que estão envolvidas na hidrólise de nucleotídeos extracelulares. Essas ectoenzimas possuem atividades ATPase e ATP pirofosfatase e são proteínas transmembrana do tipo II. A expressão do mRNA de rato relacionado foi encontrada em um subconjunto de células gliais imaturas e no trato alimentar. A proteína de rato correspondente foi detectada no pâncreas, intestino delgado, cólon e fígado. O mRNA humano é expresso em células de glioma, próstata e útero. A expressão da proteína humana foi detectada no útero, basófilos e mastócitos.[3]

Referências

  1. ↑ «Human PubMed Reference:» 
  2. ↑ Jin-Hua P, Goding JW, Nakamura H, Sano K (outubro 1997). «Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes». Genomics. 45 (2): 412–5. PMID 9344668. doi:10.1006/geno.1997.4949 
  3. ↑ a b «Entrez Gene: ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3» 

Leitura adicional

  • Bühring HJ, Streble A, Valent P (abril 2004). «The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis». International Archives of Allergy and Immunology. 133 (4): 317–29. PMID 15031605. doi:10.1159/000077351 
  • Andoh K, Piao JH, Terashima K, Nakamura H, Sano K (setembro 1999). «Genomic structure and promoter analysis of the ecto-phosphodiesterase I gene (PDNP3) expressed in glial cells». Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1446 (3): 213–24. PMID 10524196. doi:10.1016/s0167-4781(99)00090-1 
  • Bühring HJ, Seiffert M, Giesert C, Marxer A, Kanz L, Valent P, Sano K (maio 2001). «The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3». Blood. 97 (10): 3303–5. PMID 11342463. doi:10.1182/blood.V97.10.3303 
  • Yano Y, Hayashi Y, Sano K, Shinmaru H, Kuroda Y, Yokozaki H, Yoon S, Kasuga M (novembro 2003). «Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-I beta/B10/gp130RB13-6) in human colon carcinoma». International Journal of Molecular Medicine. 12 (5): 763–6. PMID 14533006. doi:10.3892/ijmm.12.5.763 
  • Yano Y, Hayashi Y, Sano K, Nagano H, Nakaji M, Seo Y, Ninomiya T, Yoon S, Yokozaki H, Kasuga M (abril 2004). «Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E-NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases». Cancer Letters. 207 (2): 139–47. PMID 15072822. doi:10.1016/j.canlet.2003.11.002 
  • Elbatarny HS, Maurice DH (outubro 2005). «Leptin-mediated activation of human platelets: involvement of a leptin receptor and phosphodiesterase 3A-containing cellular signaling complex». American Journal of Physiology. Endocrinology and Metabolism. 289 (4): E695-702. PMID 15886225. doi:10.1152/ajpendo.00125.2005 
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (janeiro 2006). «Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes». Genome Research. 16 (1): 55–65. PMC 1356129Acessível livremente. PMID 16344560. doi:10.1101/gr.4039406 
  • Ocmant A, Peignois Y, Mulier S, Hanssens L, Michils A, Schandené L (março 2007). «Flow cytometry for basophil activation markers: the measurement of CD203c up-regulation is as reliable as CD63 expression in the diagnosis of cat allergy». Journal of Immunological Methods. 320 (1–2): 40–8. PMID 17275019. doi:10.1016/j.jim.2006.12.002 
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