Corinantina

A corinantina é um alcalóide que se encontra nas espécies de Rauwolfia e Pausinystalia[1][2] Trata-se de um dos dois diastereoisómeros da ioimbina, sendo o outro a rauwolscina.[3][4] Também se esta relacionada com a ajmalicina.

A corinantina actua como um receptor adrenérgico alfa 1 e receptor adrenérgico alfa 2 antagonista com aproximadamente 10 vezes a selectividade para o primeiro em relação ao segundo.[3][4] Isto contrasta com a ioimbina e a rauwolscina, que possuem cerca de 30 vezes maior afinidade para os receptores α2-adrenérgicos em relação aos receptores α1-adrenérgicos.[3][4] Como resultado, a corinantina não é um estimulante (ou um afrodisíaco para o caso), mas um depressor, e provavelmente desempenha um papel nas propriedades anti-hipertensivas dos extractos de Rauwolfia. De maneira semelhante à ioimbina e rauwolscina, a corinantina também demonstrou possuir alguma actividade nos receptores de serotonina.[5]

Referências

  1. ↑ PHILLIPS DD, CHADHA MS (1955). «The alkaloids of Rauwolfia serpentina Benth». Journal of the American Pharmaceutical Association. American Pharmaceutical Association. 44 (9): 553–67. PMID 13251932 
  2. ↑ «Alkaloids from Rauvolfia canescens; Pharmaceutical Biology - 39(3):Pages 239-240 - Informa Healthcare» 
  3. ↑ a b c Shepperson NB, Duval N, Massingham R, Langer SZ (1981). «Pre- and postsynaptic alpha adrenoceptor selectivity studies with yohimbine and its two diastereoisomers rauwolscine and corynanthine in the anesthetized dog». The Journal of Pharmacology and Experimental Therapeutics. 219 (2): 540–6. PMID 6270312 
  4. ↑ a b c Doxey JC, Lane AC, Roach AG, Virdee NK (1984). «Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine». Naunyn-Schmiedeberg's Archives of Pharmacology. 325 (2): 136–44. PMID 6144048 
  5. ↑ Feuerstein TJ, Hertting G, Jackisch R (1985). «Endogenous noradrenaline as modulator of hippocampal serotonin (5-HT)-release. Dual effects of yohimbine, rauwolscine and corynanthine as alpha-adrenoceptor antagonists and 5-HT-receptor agonists». Naunyn-Schmiedeberg's Archives of Pharmacology. 329 (3): 216–21. PMID 2991775 

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