CUL7
Cullin-7 é uma proteína de ligase RING-E3 que em humanos é codificada pelo gene CUL7.[3][4][5]
Significado clínico
Ela está associada à síndrome 3-M.[6][7][8]
Interações
A CUL7 demonstrou interagir com a RBX1.[3]
Referências
- ↑ «Doenças geneticamente associadas a CUL7 ver/editar referências no wikidata»
- ↑ «Human PubMed Reference:»
- ↑ a b Dias DC, Dolios G, Wang R, Pan ZQ (dezembro de 2002). «CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex». Proc Natl Acad Sci U S A. 99 (26): 16601–6. PMC 139190
. PMID 12481031. doi:10.1073/pnas.252646399
- ↑ Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA (agosto de 2003). «Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis». Proc Natl Acad Sci U S A. 100 (17): 9855–60. PMC 187864. PMID 12904573. doi:10.1073/pnas.1733908100
- ↑ «Entrez Gene: CUL7 cullin 7»
- ↑ Erickson, Robert P; Wynshaw-Boris, Anthony Joseph (2016). Epstein's Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis: 3M Syndrome. Oxford Medicine Online. 3e.d. [S.l.: s.n.] ISBN 9780199934522. doi:10.1093/med/9780199934522.001.0001
- ↑ «3-M syndrome». Genetics Home Reference (GHR). 12 de dezembro de 2017
- ↑ Holder-Espinasse, Valérie; Irving, Melita; Cormier-Daire (2 de março de 2011). «Clinical utility gene card for: 3M syndrome». European Journal of Human Genetics. 19 (9). 1017 páginas. PMC 3179355. PMID 21364696. doi:10.1038/ejhg.2011.32
Leitura adicional
- Kim SS, Shago M, Kaustov L, et al. (2007). «CUL7 is a novel antiapoptotic oncogene.». Cancer Res. 67 (20): 9616–22. PMID 17942889. doi:10.1158/0008-5472.CAN-07-0644
- Jung P, Verdoodt B, Bailey A, et al. (2007). «Induction of cullin 7 by DNA damage attenuates p53 function.». Proc. Natl. Acad. Sci. U.S.A. 104 (27): 11388–93. PMC 2040908. PMID 17586686. doi:10.1073/pnas.0609467104
- Skaar JR, Florens L, Tsutsumi T, et al. (2007). «PARC and CUL7 form atypical cullin RING ligase complexes.». Cancer Res. 67 (5): 2006–14. PMID 17332328. doi:10.1158/0008-5472.CAN-06-3241
- Kaustov L, Lukin J, Lemak A, et al. (2007). «The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53.». J. Biol. Chem. 282 (15): 11300–7. PMID 17298945. doi:10.1074/jbc.M611297200
- Kasper JS, Arai T, DeCaprio JA (2006). «A novel p53-binding domain in CUL7.». Biochem. Biophys. Res. Commun. 348 (1): 132–8. PMID 16875676. doi:10.1016/j.bbrc.2006.07.013
- Andrews P, He YJ, Xiong Y (2006). «Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function.». Oncogene. 25 (33): 4534–48. PMID 16547496. doi:10.1038/sj.onc.1209490
- Huber C, Dias-Santagata D, Glaser A, et al. (2005). «Identification of mutations in CUL7 in 3-M syndrome.». Nat. Genet. 37 (10): 1119–24. PMID 16142236. doi:10.1038/ng1628
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). «The DNA sequence and analysis of human chromosome 6.». Nature. 425 (6960): 805–11. PMID 14574404. doi:10.1038/nature02055
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
- Nakayama M, Kikuno R, Ohara O (2003). «Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.». Genome Res. 12 (11): 1773–84. PMC 187542. PMID 12421765. doi:10.1101/gr.406902
- Winston JT, Koepp DM, Zhu C, et al. (1999). «A family of mammalian F-box proteins.». Curr. Biol. 9 (20): 1180–2. PMID 10531037. doi:10.1016/S0960-9822(00)80021-4
- Nomura N, Nagase T, Miyajima N, et al. (1995). «Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.». DNA Res. 1 (5): 223–9. PMID 7584044. doi:10.1093/dnares/1.5.223
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