CGP-35348
CGP-35348
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| Nome IUPAC | 3-Aminopropyl(diethoxymethyl)phosphinic acid | ||||||||
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| Página de dados suplementares | |||||||||
| Estrutura e propriedades | n, εr, etc. | ||||||||
| Dados termodinâmicos | Phase behaviour Solid, liquid, gas | ||||||||
| Dados espectrais | UV, IV, RMN, EM | ||||||||
| Exceto onde denotado, os dados referem-se a materiais sob condições normais de temperatura e pressão. Referências e avisos gerais sobre esta caixa. Alerta sobre risco à saúde. | |||||||||
CGP-35348 é um composto químico utilizado em pesquisas científicas que actua como antagonista dos subreceptores GABAB .[1][2][3]
Em ensaio clínico, O CGP-35348 foi ineficaz em antagonizar a inibição de recaptação do GABA induzida por baclofeno, tornando-o um fármaco seletivo como antagonista heterorreceptor do GABAB.[4] Além disso, CGP-35348 foi cerca de três vezes menos potente em antagonismo o gama-hidroxibutirato (GHB) e gama-butirolactona (GBL) quando comparado com baclofeno e o SKF-97,541 .[5]
Referências
- ↑ Carter LP, Chen W, Coop A, Koek W, France CP (maio de 2006). «Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348». European Journal of Pharmacology. 538: 85–93. PMID 16647701. doi:10.1016/j.ejphar.2006.03.039
- ↑ Nasrallah FA, Griffin JL, Balcar VJ, Rae C (agosto de 2007). «Understanding your inhibitions: modulation of brain cortical metabolism by GABA(B) receptors». Journal of Cerebral Blood Flow and Metabolism. 27: 1510–20. PMID 17293844. doi:10.1038/sj.jcbfm.9600453
- ↑ Koek W, Mercer SL, Coop A, France CP (setembro de 2009). «Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348)». The Journal of Pharmacology and Experimental Therapeutics. 330: 876–83. PMC 2729800
. PMID 19564487. doi:10.1124/jpet.109.151845
- ↑ Maurizio Raiteri (2006). «Functional Pharmacology in Human Brain». Pharmacological Reviews. 58: 162–193. PMID 16714485. doi:10.1124/pr.58.2.5
- ↑ Koek W1, Mercer SL, Coop A. (junho de 2007). «Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348.». Psychopharmacology. 192: 407–14. PMID 17277933. doi:10.1007/s00213-007-0718-y
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