CCNC
A ciclina-C é uma proteína que em humanos é codificada pelo gene CCNC. A proteína codificada por este gene é um membro da família de proteínas ciclina.[2][3] A proteína codificada interage com quinase 8 dependente de ciclina e induz a fosforilação do domínio carboxi-terminal da subunidade grande da RNA polimerase II.[3]
Referências
- ↑ «Human PubMed Reference:»
- ↑ Lew DJ, Dulic V, Reed SI (outubro de 1991). «Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast». Cell. 66 (6): 1197–206. PMID 1833066. doi:10.1016/0092-8674(91)90042-W
- ↑ a b «Entrez Gene: CCNC cyclin C»
Leitura adicional
- Nozawa T, Hatano M, Yamamoto H, Kwan T (1976). «Magnetic circular dichroism on the reversible oxygenation of dimethylmesoporphyrin-IX-atopyridinecobalt (II)». Bioinorganic Chemistry. 5 (3): 267–73. PMID 1260071. doi:10.1016/S0006-3061(00)82025-6
- Tassan JP, Jaquenoud M, Léopold P, et al. (1995). «Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C». Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8871–5. Bibcode:1995PNAS...92.8871T. PMC 41069
. PMID 7568034. doi:10.1073/pnas.92.19.8871 - Demetrick DJ, Matsumoto S, Hannon GJ, et al. (1995). «Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)». Cytogenet. Cell Genet. 69 (3–4): 190–2. PMID 7698009. doi:10.1159/000133960
- Yoshizumi M, Lee WS, Hsieh CM, et al. (1995). «Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts». J. Clin. Invest. 95 (5): 2275–80. PMC 295840. PMID 7738192. doi:10.1172/JCI117918
- Maruyama K, Sugano S (1994). «Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides». Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8
- Rickert P, Seghezzi W, Shanahan F, et al. (1996). «Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II». Oncogene. 12 (12): 2631–40. PMID 8700522
- Li H, Lahti JM, Valentine M, et al. (1997). «Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors». Genomics. 32 (2): 253–9. PMID 8833152. doi:10.1006/geno.1996.0112
- Cujec TP, Cho H, Maldonado E, et al. (1997). «The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme». Mol. Cell. Biol. 17 (4): 1817–23. PMC 232028. PMID 9121429. doi:10.1128/MCB.17.4.1817
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). «Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library». Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3
- Neish AS, Anderson SF, Schlegel BP, et al. (1998). «Factors associated with the mammalian RNA polymerase II holoenzyme». Nucleic Acids Res. 26 (3): 847–53. PMC 147327. PMID 9443979. doi:10.1093/nar/26.3.847
- Cho H, Orphanides G, Sun X, et al. (1998). «A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure». Mol. Cell. Biol. 18 (9): 5355–63. PMC 109120. PMID 9710619. doi:10.1128/MCB.18.9.5355
- Sun X, Zhang Y, Cho H, et al. (1998). «NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription». Mol. Cell. 2 (2): 213–22. PMID 9734358. doi:10.1016/S1097-2765(00)80131-8
- Gu W, Malik S, Ito M, et al. (1999). «A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation». Mol. Cell. 3 (1): 97–108. PMID 10024883. doi:10.1016/S1097-2765(00)80178-1
- Ito M, Yuan CX, Malik S, et al. (1999). «Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators». Mol. Cell. 3 (3): 361–70. PMID 10198638. doi:10.1016/S1097-2765(00)80463-3
- Rachez C, Lemon BD, Suldan Z, et al. (1999). «Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex». Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. PMID 10235266. doi:10.1038/19783
- Wang G, Cantin GT, Stevens JL, Berk AJ (2001). «Characterization of Mediator Complexes from HeLa Cell Nuclear Extract». Mol. Cell. Biol. 21 (14): 4604–13. PMC 87123. PMID 11416138. doi:10.1128/MCB.21.14.4604-4613.2001
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
- Sato S, Tomomori-Sato C, Banks CA, et al. (2003). «Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3». J. Biol. Chem. 278 (17): 15123–7. PMID 12584197. doi:10.1074/jbc.C300054200
- Ueberham U, Hessel A, Arendt T (2003). «Cyclin C expression is involved in the pathogenesis of Alzheimer's disease». Neurobiol. Aging. 24 (3): 427–35. PMID 12600719. doi:10.1016/S0197-4580(02)00132-X
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