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VIPR2
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2X57
معین‌کننده‌ها
نام‌های دیگر	VIPR2, C16DUPq36.3, DUP7q36.3, PACAP-R-3, PACAP-R3, VIP-R-2, VPAC2, VPAC2R, VPCAP2R, vasoactive intestinal peptide receptor 2
شناسه‌های بیرونی	OMIM: 601970; MGI: 107166; HomoloGene: 2540; GeneCards: VIPR2; OMA:VIPR2 - orthologs
موقعیت ژن (انسان)
کروموزوم	کروموزوم ۷ (انسان)
پایان	159,144,867 bp
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۲ (موش)
پایان	116,109,881 bp
الگوی گسترش RNA
	بیشترین بیان در
	gastric mucosa; ; apex of heart; ; body of pancreas; ; tibial arteries; ; Descending thoracic aorta; ; left ovary; ; muscle layer of sigmoid colon;
	بیشترین بیان در
	neural layer of retina; ; suprachiasmatic nucleus; ; cerebellar cortex; ; ventricular zone; ; muscle of thigh; ; dentate gyrus of hippocampal formation granule cell;
	داده‌های بیشتر بیان
	; ; ; ;
	داده‌های بیشتر بیان
هستی‌شناسی ژن
عملکرد ملکولی	G protein-coupled receptor activity; vasoactive intestinal polypeptide receptor activity; transmembrane signaling receptor activity; signal transducer activity; G protein-coupled peptide receptor activity; peptide hormone binding;
ترکیبات سلولی	integral component of membrane; پوسته یاخته; integral component of plasma membrane; membrane;
فرایند زیستی	cell-cell signaling; cell surface receptor signaling pathway; negative regulation of smooth muscle cell proliferation; ورارسانی پیام; activation of adenylate cyclase activity; G protein-coupled receptor signaling pathway;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	7434
	22355
	ENSG00000106018
	ENSMUSG00000011171
	P41587
	P41588
	NM_001304522; NM_001308259; NM_003382
	NM_009511
	NP_001291451; NP_001295188; NP_003373
	NP_033537
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرنده ۲ پپتید وازواکتیو روده‌ای (انگلیسی: Vasoactive intestinal peptide receptor 2) که با نام VPAC₂ هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «VIPR2» کدگذاری می‌شود.^[۵]

این پروتئین در رحم، پروستات، ماهیچه صاف دستگاه گوارش، کیسه منی، پوست، رگ‌های خونی و تیموس بیان می‌شود.^[۶]^[۷] این پروتئین در مخچه هم یافت می‌شود.^[۸]

اهمیت بالینی

VIPR2 در بروز بیماری اسکیزوفرنی نقش دارد.^[۹]

بیان غیرعادی آران‌ای پیام‌رسان این پروتئین در بافت کیسه صفرا، در تشکیل پولیپ و سنگ کیسه صفرا نقش دارد.^[۱۰]

جستارهای وابسته

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000106018 – Ensembl, May 2017
↑ ^۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000011171 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: VIPR2 vasoactive intestinal peptide receptor 2". Archived from the original on 5 دسامبر 2010.
↑ Reubi JC (2000). "In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications". Ann N Y Acad Sci. 921 (1): 1–25. doi:10.1111/j.1749-6632.2000.tb06946.x. PMID 11193811.
↑ Reubi JC, Laderach U, Waser B, Gebbers JO, Robberecht P, Laissue JA (2000). "Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin". Cancer Res. 60 (11): 3105–3112. PMID 10850463.
↑ Basille M, Cartier D, Vaudry D, Lihrmann I, Fournier A, Freger P, Gallo-Payet N, Vaudry H, Gonzalez B (June 2006). "Localization and characterization of pituitary adenylate cyclase-activating polypeptide receptors in the human cerebellum during development". J. Comp. Neurol. 496 (4): 468–78. doi:10.1002/cne.20934. PMID 16572459.
↑ Levinson DF, Duan J, Oh S, Wang K, Sanders AR, Shi J, Zhang N, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Kendler KS, Freedman R, Dudbridge F, Pe'er I, Hakonarson H, Bergen SE, Fanous AH, Holmans PA, Gejman PV (February 2011). "Copy Number Variants in Schizophrenia: Confirmation of Five Previous Findings and New Evidence for 3q29 Microdeletions and VIPR2 Duplications". Am J Psychiatry. 168 (3): 302–316. doi:10.1176/appi.ajp.2010.10060876. PMID 21285140.
↑ Zhang ZH, Wu SD, Gao H, Shi G, Jin JZ, Kong J, Tian Z, Su Y (March 2006). "Expression of pituitary adenylate cyclase-activating polypeptide 1 and 2 receptor mRNA in gallbladder tissue of patients with gallstone or gallbladder polyps". World J. Gastroenterol. 12 (9): 1468–71. PMID 16552823.

مشارکت‌کنندگان ویکی‌پدیا. «VIPR2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ دسامبر ۲۰۱۸.

برای مطالعهٔ بیشتر

Goetzl EJ, Pankhaniya RR, Gaufo GO, et al. (1998). "Selectivity of effects of vasoactive intestinal peptide on macrophages and lymphocytes in compartmental immune responses". Ann. N. Y. Acad. Sci. 840 (1 NEUROIMMUNOMO): 540–50. doi:10.1111/j.1749-6632.1998.tb09593.x. PMID 9629281.
Adamou JE, Aiyar N, Van Horn S, Elshourbagy NA (1995). "Cloning and functional characterization of the human vasoactive intestinal peptide (VIP)-2 receptor". Biochem. Biophys. Res. Commun. 209 (2): 385–92. doi:10.1006/bbrc.1995.1515. PMID 7733904.
Svoboda M, Tastenoy M, Van Rampelbergh J, et al. (1995). "Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts". Biochem. Biophys. Res. Commun. 205 (3): 1617–24. doi:10.1006/bbrc.1994.2852. PMID 7811244.
Inagaki N, Yoshida H, Mizuta M, et al. (1994). "Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells". Proc. Natl. Acad. Sci. U.S.A. 91 (7): 2679–83. doi:10.1073/pnas.91.7.2679. PMC 43433. PMID 8146174.
Xia M, Gaufo GO, Wang Q, et al. (1996). "Transduction of specific inhibition of HuT 78 human T cell chemotaxis by type I vasoactive intestinal peptide receptors". J. Immunol. 157 (3): 1132–8. PMID 8757618.
Wei Y, Mojsov S (1997). "Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology". J. Neuroendocrinol. 8 (11): 811–7. doi:10.1046/j.1365-2826.1996.05191.x. PMID 8933357.
Mackay M, Fantes J, Scherer S, et al. (1997). "Chromosomal localization in mouse and human of the vasoactive intestinal peptide receptor type 2 gene: a possible contributor to the holoprosencephaly 3 phenotype". Genomics. 37 (3): 345–53. doi:10.1006/geno.1996.0569. PMID 8938447.
Nicole P, Du K, Couvineau A, Laburthe M (1998). "Site-directed mutagenesis of human vasoactive intestinal peptide receptor subtypes VIP1 and VIP2: evidence for difference in the structure-function relationship". J. Pharmacol. Exp. Ther. 284 (2): 744–50. PMID 9454823.
Dewit D, Gourlet P, Amraoui Z, et al. (1998). "The vasoactive intestinal peptide analogue RO25-1553 inhibits the production of TNF and IL-12 by LPS-activated monocytes". Immunol. Lett. 60 (1): 57–60. doi:10.1016/S0165-2478(97)00129-6. PMID 9541464.
Lutz EM, Shen S, Mackay M, et al. (1999). "Structure of the human VIPR2 gene for vasoactive intestinal peptide receptor type 2". FEBS Lett. 458 (2): 197–203. doi:10.1016/S0014-5793(99)01135-7. PMID 10481065.
Busto R, Prieto JC, Bodega G, et al. (2000). "Immunohistochemical localization and distribution of VIP/PACAP receptors in human lung". Peptides. 21 (2): 265–9. doi:10.1016/S0196-9781(99)00202-8. PMID 10764955.
Nicole P, Lins L, Rouyer-Fessard C, et al. (2000). "Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide". J. Biol. Chem. 275 (31): 24003–12. doi:10.1074/jbc.M002325200. PMID 10801840.{{cite journal}}: نگهداری یادکرد:doi رایگان بی‌نشان (رده)
Bajo AM, Juarranz MG, Valenzuela P, et al. (2001). "Expression of vasoactive intestinal peptide (VIP) receptors in human uterus". Peptides. 21 (9): 1383–8. doi:10.1016/S0196-9781(00)00282-5. PMID 11072126.
Lara-Marquez M, O'Dorisio M, O'Dorisio T, et al. (2001). "Selective gene expression and activation-dependent regulation of vasoactive intestinal peptide receptor type 1 and type 2 in human T cells". J. Immunol. 166 (4): 2522–30. doi:10.4049/jimmunol.166.4.2522. PMID 11160313.
Lara-Marquez ML, O'Dorisio MS, Karacay B (2001). "Vasoactive intestinal peptide (VIP) receptor type 2 (VPAC2) is the predominant receptor expressed in human thymocytes". Ann. N. Y. Acad. Sci. 921 (1): 45–54. doi:10.1111/j.1749-6632.2000.tb06950.x. PMID 11193874.
Groneberg DA, Hartmann P, Dinh QT, Fischer A (2001). "Expression and distribution of vasoactive intestinal polypeptide receptor VPAC(2) mRNA in human airways". Lab. Invest. 81 (5): 749–55. doi:10.1038/labinvest.3780283. PMID 11351046.
Juarranz MG, Bolaños O, Gutiérrez-Cañas I, et al. (2002). "Neuroendocrine differentiation of the LNCaP prostate cancer cell line maintains the expression and function of VIP and PACAP receptors". Cell. Signal. 13 (12): 887–94. doi:10.1016/S0898-6568(01)00199-1. PMID 11728828.
Fischer TC, Dinh QT, Peiser C, et al. (2002). "Simultaneous detection of receptor mRNA and ligand protein in human skin tissues". J. Cutan. Pathol. 29 (2): 65–71. doi:10.1034/j.1600-0560.2002.290201.x. PMID 12150135.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000106018 – Ensembl, May 2017

[refGRCm38Ensembl-2] ۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000011171 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: VIPR2 vasoactive intestinal peptide receptor 2". Archived from the original on 5 دسامبر 2010.

[pmid11193811-6] Reubi JC (2000). "In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications". Ann N Y Acad Sci. 921 (1): 1–25. doi:10.1111/j.1749-6632.2000.tb06946.x. PMID 11193811.

[pmid10850463-7] Reubi JC, Laderach U, Waser B, Gebbers JO, Robberecht P, Laissue JA (2000). "Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin". Cancer Res. 60 (11): 3105–3112. PMID 10850463.

[Basille-2006-8] Basille M, Cartier D, Vaudry D, Lihrmann I, Fournier A, Freger P, Gallo-Payet N, Vaudry H, Gonzalez B (June 2006). "Localization and characterization of pituitary adenylate cyclase-activating polypeptide receptors in the human cerebellum during development". J. Comp. Neurol. 496 (4): 468–78. doi:10.1002/cne.20934. PMID 16572459.

[Levinson-2011-9] Levinson DF, Duan J, Oh S, Wang K, Sanders AR, Shi J, Zhang N, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Kendler KS, Freedman R, Dudbridge F, Pe'er I, Hakonarson H, Bergen SE, Fanous AH, Holmans PA, Gejman PV (February 2011). "Copy Number Variants in Schizophrenia: Confirmation of Five Previous Findings and New Evidence for 3q29 Microdeletions and VIPR2 Duplications". Am J Psychiatry. 168 (3): 302–316. doi:10.1176/appi.ajp.2010.10060876. PMID 21285140.

[Zhang-2006-10] Zhang ZH, Wu SD, Gao H, Shi G, Jin JZ, Kong J, Tian Z, Su Y (March 2006). "Expression of pituitary adenylate cyclase-activating polypeptide 1 and 2 receptor mRNA in gallbladder tissue of patients with gallstone or gallbladder polyps". World J. Gastroenterol. 12 (9): 1468–71. PMID 16552823.

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VIPR2

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