TCERG1

TCERG1

ساختارهای موجود

جستجوی هم‌ساخت‌شناسی: PDBe RCSB

فهرست شناسه‌های PDB
2DK7, 2DOD, 2DOE, 2DOF, 2E71, 2KIQ, 2KIS, 2MW9, 2MWA, 2MWB, 2MWD, 2MWF, 2NNT, 3HFH, 3Q1I, 4FQG, 2N4R, 2N4S, 2N4T, 2N4U, 2N4V, 2N4W

معین‌کننده‌ها

نام‌های دیگر

TCERG1, CA150, TAF2S, Urn1, transcription elongation regulator 1

شناسه‌های بیرونی

OMIM: 605409; MGI: 1926421; HomoloGene: 4879; GeneCards: TCERG1; OMA:TCERG1 - orthologs

موقعیت ژن (انسان)

کروموزوم	کروموزوم ۵ (انسان)^[۱]

نوار	5q32	شروع	146,447,311 bp^[۱]
نوار	5q32	پایان	146,511,961 bp^[۱]

موقعیت ژن (موش)

کروموزوم	کروموزوم ۱۸ (موش)^[۲]

نوار	18\|18 B3	شروع	42,644,552 bp^[۲]
نوار	18\|18 B3	پایان	42,708,858 bp^[۲]

الگوی گسترش RNA

انسان

موش (هم‌ساخت)

بیشترین بیان در

right hemisphere of cerebellum

right uterine tube

ventricular zone

ganglionic eminence

left ovary

right ovary

skin of abdomen

بیشترین بیان در

tail of embryo

ventricular zone

neural layer of retina

secondary oocyte

dentate gyrus of hippocampal formation granule cell

داده‌های بیشتر بیان


داده‌های بیشتر بیان

هستی‌شناسی ژن
عملکرد ملکولی	transcription coactivator activity transcription corepressor activity proline-rich region binding پیوند پروتئینی RNA binding identical protein binding RNA polymerase binding
ترکیبات سلولی	هسته یاخته نوکلئوپلاسم
فرایند زیستی	regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated positive regulation of nucleic acid-templated transcription
منابع: آمیگو / کوئیک‌گو

هم‌ساخت‌شناسی

گونه‌ها

انسان

موش


10915


56070


ENSG00000113649


ENSMUSG00000024498


O14776


Q8CGF7

RefSeq (mRNA)


NM_001040006 NM_006706 NM_001382548


NM_001039474 NM_001289526 NM_001360881 NM_019512

RefSeq (پروتئین)


NP_001035095 NP_006697 NP_001369477


NP_001034563 NP_001276455 NP_001347810

موقعیت (UCSC)

Chr 5: 146.45 – 146.51 Mb

Chr 18: 42.64 – 42.71 Mb

جستجوی PubMed

^[۳]

^[۴]

ویکی‌داده

مشاهده/ویرایش انسان

مشاهده/ویرایش موش

تنظیم‌کنندهٔ ۱ تطویل رونویسی (انگلیسی: Transcription elongation regulator 1) یک پروتئین است که در انسان توسط ژن «TCERG1» کُدگذاری می‌شود.^[۵]^[۶]^[۷]

این پروتئین با هانتینگتین و POLR2A^[۸] تعامل پروتئین-پروتئین دارد.

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000113649 – Ensembl, May 2017
↑ ^۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000024498 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TCERG1 transcription elongation regulator 1".
↑ Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Molecular and Cellular Biology. 17 (10): 6029–39. doi:10.1128/MCB.17.10.6029. PMC 232452. PMID 9315662. Archived from the original on 3 ژوئیه 2006. Retrieved 12 ژوئن 2019.
↑ Bohne J, Cole SE, Suñe C, Lindman BR, Ko VD, Vogt TF, Garcia-Blanco MA (October 2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mammalian Genome. 11 (10): 930–3. doi:10.1007/s003350010162. PMID 11003711.
↑ Carty, S M; Goldstrohm A C; Suñé C; Garcia-Blanco M A; Greenleaf A L (August 2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9015–20. Bibcode:2000PNAS...97.9015C. doi:10.1073/pnas.160266597. ISSN 0027-8424. PMC 16813. PMID 10908677.

مشارکت‌کنندگان ویکی‌پدیا. «Transcription elongation regulator 1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۲ ژوئن ۲۰۱۹.

برای مطالعهٔ بیشتر

Suñé C, Hayashi T, Liu Y, et al. (1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. 17 (10): 6029–39. doi:10.1128/MCB.17.10.6029. PMC 232452. PMID 9315662.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
Suñé C, Garcia-Blanco MA (1999). "Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner". Mol. Cell. Biol. 19 (7): 4719–28. doi:10.1128/MCB.19.7.4719. PMC 84270. PMID 10373521.
Carty SM, Goldstrohm AC, Suñé C, et al. (2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9015–20. Bibcode:2000PNAS...97.9015C. doi:10.1073/pnas.160266597. PMC 16813. PMID 10908677.
Bohne J, Cole SE, Suñe C, et al. (2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mamm. Genome. 11 (10): 930–3. doi:10.1007/s003350010162. PMID 11003711.
Holbert S, Denghien I, Kiechle T, et al. (2001). "The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1811–6. doi:10.1073/pnas.041566798. PMC 29339. PMID 11172033.
Goldstrohm AC, Albrecht TR, Suñé C, et al. (2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. PMC 99933. PMID 11604498.
Zhou Z, Licklider LJ, Gygi SP, Reed R (2002). "Comprehensive proteomic analysis of the human spliceosome". Nature. 419 (6903): 182–5. Bibcode:2002Natur.419..182Z. doi:10.1038/nature01031. PMID 12226669.
Carty SM, Greenleaf AL (2003). "Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing". Mol. Cell. Proteomics. 1 (8): 598–610. doi:10.1074/mcp.M200029-MCP200. PMID 12376575.{{cite journal}}: نگهداری یادکرد:doi رایگان بی‌نشان (رده)
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chattopadhyay B, Ghosh S, Gangopadhyay PK, et al. (2003). "Modulation of age at onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India". Neurosci. Lett. 345 (2): 93–6. doi:10.1016/S0304-3940(03)00436-1. PMID 12821179.
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Palancade B, Marshall NF, Tremeau-Bravard A, et al. (2004). "Dephosphorylation of RNA polymerase II by CTD-phosphatase FCP1 is inhibited by phospho-CTD associating proteins". J. Mol. Biol. 335 (2): 415–24. doi:10.1016/j.jmb.2003.10.036. PMID 14672652.
Nagel JE, Smith RJ, Shaw L, et al. (2005). "Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10". BMC Immunol. 5: 17. doi:10.1186/1471-2172-5-17. PMC 514893. PMID 15296517.{{cite journal}}: نگهداری یادکرد:doi رایگان بی‌نشان (رده)
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884. PMID 15456888.
Smith MJ, Kulkarni S, Pawson T (2004). "FF domains of CA150 bind transcription and splicing factors through multiple weak interactions". Mol. Cell. Biol. 24 (21): 9274–85. doi:10.1128/MCB.24.21.9274-9285.2004. PMC 522232. PMID 15485897.
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McFie PJ, Wang GL, Timchenko NA, et al. (2006). "Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha". J. Biol. Chem. 281 (26): 18069–80. doi:10.1074/jbc.M512734200. PMID 16644732.{{cite journal}}: نگهداری یادکرد:doi رایگان بی‌نشان (رده)

نگارخانه بانک داده پروتئین

1e0l: FBP28WW DOMAIN FROM MUS MUSCULUS
2dk7: Solution structure of WW domain in transcription elongation regulator 1
2dod: Solution structure of the first FF domain of human transcription factor CA150
2doe: Solution structure of the third FF domain of human transcription factor CA150
2dof: Solution structure of the fourth FF domain of human transcription factor CA150
2nnt: General structural motifs of amyloid protofilaments

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

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