SMG1
پروتئین کیناز سرین/ترئونین اسامجی ۱ (انگلیسی: Serine/threonine-protein kinase SMG1) یک آنزیم است که در انسان توسط ژن «SMG1» کُدگذاری میشود.[۵][۶][۷][۸] این پروتئین یکی از اعضای خانوادهٔ کیناز وابسته به فسفاتیدیلاینوزیتول ۳-کیناز است و در فرایند «تحلیل بهواسطهٔ جهش بیمعنی» دخالت دارد.
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCh38: Ensembl release 89: ENSG00000157106 – Ensembl, May 2017
- ↑ ۲٫۰ ۲٫۱ ۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000030655 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
- ↑ Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP (June 2001). "Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein". J. Biol. Chem. 276 (25): 22709–14. doi:10.1074/jbc.C100144200. PMID 11331269.
- ↑ Morita T, Yamashita A, Kashima I, Ogata K, Ishiura S, Ohno S (March 2007). "Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay". J. Biol. Chem. 282 (11): 7799–808. doi:10.1074/jbc.M610159200. PMID 17229728.
- ↑ "Entrez Gene: SMG1 PI-3-kinase-related kinase SMG-1".
- مشارکتکنندگان ویکیپدیا. «SMG1». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۱۳ سپتامبر ۲۰۲۲.
بیشتر بخوانید
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- Abraham RT (2005). "The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways". DNA Repair (Amst.). 3 (8–9): 919–25. doi:10.1016/j.dnarep.2004.04.003. PMID 15279777.
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- Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S (2001). "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay". Genes Dev. 15 (17): 2215–28. doi:10.1101/gad.913001. PMC 312771. PMID 11544179.
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- Chiu SY, Serin G, Ohara O, Maquat LE (2003). "Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1". RNA. 9 (1): 77–87. doi:10.1261/rna.2137903. PMC 1370372. PMID 12554878.
- Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, Hachiya T, Hentze MW, Anderson P, Ohno S (2003). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7". Mol. Cell. 12 (5): 1187–200. doi:10.1016/S1097-2765(03)00443-X. PMID 14636577.
- Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, Lejeune F, Tibbetts RS, Maquat LE, Abraham RT (2004). "The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells". Mol. Cell. 14 (5): 585–98. doi:10.1016/j.molcel.2004.05.005. PMID 15175154.
- Kashima I, Yamashita A, Izumi N, Kataoka N, Morishita R, Hoshino S, Ohno M, Dreyfuss G, Ohno S (2006). "Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay". Genes Dev. 20 (3): 355–67. doi:10.1101/gad.1389006. PMC 1361706. PMID 16452507.
- Azzalin CM, Lingner J (2006). "The human RNA surveillance factor UPF1 is required for S phase progression and genome stability". Curr. Biol. 16 (4): 433–9. doi:10.1016/j.cub.2006.01.018. PMID 16488880. S2CID 17197870.
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