SCP2
پروتئین غیراختصاصی حملکنندهٔ چربی (انگلیسی: Non-specific lipid-transfer protein) که با نامهای دیگری همچون پروتئین شمارهٔ ۲ حملکنندهٔ استرول (SCP-2) و پروپانویل-کوآ سی-استیلترانفراز هم شناخته میشود، یک پروتئین است که در انسان توسط ژن ژن «SCP2» کُدگذاری میشود.[۵][۶]
اهمیت بالینی
این پروتئین به میزان فراوانی در اعضایی از بدن، که در سوختوساز چربی نقش دارند بیان میگردد و احتمالاً در بروز سندرم زلوگر هم نقش داشته باشد که در آن ساختِ اسیدهای صفراوی مختل است.[۷]
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCh38: Ensembl release 89: ENSG00000116171 – Ensembl, May 2017
- ↑ ۲٫۰ ۲٫۱ ۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000028603 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Yamamoto R, Kallen CB, Babalola GO, Rennert H, Billheimer JT, Strauss JF (January 1991). "Cloning and expression of a cDNA encoding human sterol carrier protein 2". Proc. Natl. Acad. Sci. U.S.A. 88 (2): 463–7. doi:10.1073/pnas.88.2.463. PMC 50831. PMID 1703300.
- ↑ He Z, Yamamoto R, Furth EE, Schantz LJ, Naylor SL, George H, Billheimer JT, Strauss JF (October 1991). "cDNAs encoding members of a family of proteins related to human sterol carrier protein 2 and assignment of the gene to human chromosome 1 p21----pter". DNA Cell Biol. 10 (8): 559–69. doi:10.1089/dna.1991.10.559. PMID 1718316.
- ↑ "Entrez Gene: SCP2 sterol carrier protein 2".
- مشارکتکنندگان ویکیپدیا. «SCP2». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۱۵ سپتامبر ۲۰۱۹.
برای مطالعهٔ بیشتر
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- Yamamoto R (1993). "[Localization of human sterol carrier protein 2 gene and cDNA expression in COS-7 cell]". Hokkaido Igaku Zasshi. 67 (6): 839–48. PMID 1483685.
- Baker ME, Billheimer JT, Strauss JF (1992). "Similarity between the amino-terminal portion of mammalian 58-kD sterol carrier protein (SCPx) and Escherichia coli acetyl-CoA acyltransferase: evidence for a gene fusion in SCPx". DNA Cell Biol. 10 (9): 695–8. doi:10.1089/dna.1991.10.695. PMID 1755959.
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- Ohba T, Rennert H, Pfeifer SM, et al. (1995). "The structure of the human sterol carrier protein X/sterol carrier protein 2 gene (SCP2)". Genomics. 24 (2): 370–4. doi:10.1006/geno.1994.1630. PMID 7698762.
- Woodford JK, Colles SM, Myers-Payne S, et al. (1995). "Sterol carrier protein-2 stimulates intermembrane sterol transfer by direct membrane interaction". Chem. Phys. Lipids. 76 (1): 73–84. doi:10.1016/0009-3084(95)02436-M. PMID 7788802.
- Vesa J, Hellsten E, Barnoski BL, et al. (1994). "Assignment of sterol carrier protein X/sterol carrier protein 2 to 1p32 and its exclusion as the causative gene for infantile neuronal ceroid lipofuscinosis". Hum. Mol. Genet. 3 (2): 341–6. doi:10.1093/hmg/3.2.341. PMID 8004106.
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